Modular amphiphilic poly(aryl ether)-based supramolecular nanomicelles: An efficient endocytic drug carrier

2021 ◽  
Author(s):  
Ramya Kannan ◽  
Ayan Datta ◽  
Palani Prabakaran ◽  
Prasad Edamana ◽  
Vignesh Muthuvijayan
Keyword(s):  
Chain Length ◽  
Drug Carrier ◽  
The Self ◽  
Aryl Ether ◽  
Self Assembled ◽  
Tunable Morphology

A rationally designed amphiphilic poly(aryl ether)-based dendrimer self-assembles into nanomicelles and exhibits tunable morphology upon varying the hydrophilic chain length. The self-assembled 30 nm-sized dendrimer nanomicelles successfully entrapped doxorubicin, demonstrated...

Transition from vesicles to nanofibres in the enzymatic self-assemblies of an amphiphilic peptide as an antitumour drug carrier

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15479-15486 ◽  
Author(s):  
Zhongying Gong ◽  
Xiaoying Liu ◽  
Jinhua Dong ◽  
Weifen Zhang ◽  
Yuanfei Jiang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Drug Carrier ◽  
The Self ◽  
Amphiphilic Peptide ◽  
Self Assembled ◽  
Antitumour Drug

The enzyme-responsive self-assembly of the amphiphilic peptide A6K2 and the release of an antitumour drug (DOX) from the self-assembled nanovesicles of the amphiphilic peptide.

Linear Long Alkyl Chain Substituted POSS Cages: The Effect of Alkyl Chain Length on the Self-Assembled Packing Morphology

2013 ◽  
Vol 46 (12) ◽  
pp. 4944-4954 ◽  
Author(s):  
Ellen L. Heeley ◽  
Darren J. Hughes ◽  
Youssef El Aziz ◽  
Peter G. Taylor ◽  
Alan R. Bassindale
Keyword(s):  
Chain Length ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
The Self ◽  
Self Assembled ◽  
Long Alkyl Chain

Nanoscale Self-Assembly Using Ion and Electron Beam Techniques: A Rapid Review

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3507-3520
Author(s):  
Chunhui Dai ◽  
Kriti Agarwal ◽  
Jeong-Hyun Cho
Keyword(s):  
Electron Beam ◽  
Self Assembly ◽  
Ion Beam ◽  
Three Dimensional ◽  
The Self ◽  
Stress Generation ◽  
Rapid Review ◽  
High Yield ◽  
3D Nanostructures ◽  
Self Assembled

AbstractNanoscale self-assembly, as a technique to transform two-dimensional (2D) planar patterns into three-dimensional (3D) nanoscale architectures, has achieved tremendous success in the past decade. However, an assembly process at nanoscale is easily affected by small unavoidable variations in sample conditions and reaction environment, resulting in a low yield. Recently, in-situ monitored self-assembly based on ion and electron irradiation has stood out as a promising candidate to overcome this limitation. The usage of ion and electron beam allows stress generation and real-time observation simultaneously, which significantly enhances the controllability of self-assembly. This enables the realization of various complex 3D nanostructures with a high yield. The additional dimension of the self-assembled 3D nanostructures opens the possibility to explore novel properties that cannot be demonstrated in 2D planar patterns. Here, we present a rapid review on the recent achievements and challenges in nanoscale self-assembly using electron and ion beam techniques, followed by a discussion of the novel optical properties achieved in the self-assembled 3D nanostructures.

Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

2020 ◽  
Vol 27 (9) ◽  
pp. 923-929
Author(s):  
Gaurav Pandey ◽  
Prem Prakash Das ◽  
Vibin Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Amino Acids ◽  
Light Scattering ◽  
Chain Length ◽  
Self Assembly ◽  
The Self ◽  
Ionic Charge ◽  
Self Assembling ◽  
Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

scholarly journals Self-Assembly of Shape-Tunable Oblate Colloidal Particles into Orientationally Ordered Crystals, Glassy Crystals and Plastic Crystals

Soft Matter ◽  
2021 ◽  
Author(s):  
Jiawei Lu ◽  
Xiangyu Bu ◽  
Xinghua Zhang ◽  
Bing Liu
Keyword(s):  
Crystal Structures ◽  
Self Assembly ◽  
Colloidal Particles ◽  
Building Blocks ◽  
Fundamental Question ◽  
The Self ◽  
Plastic Crystals ◽  
Self Assembled ◽  
Glassy Crystals ◽  
The Relationship

The shapes of colloidal particles are crucial to the self-assembled superstructures. Understanding the relationship between the shapes of building blocks and the resulting crystal structures is an important fundamental question....

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