Copper(I)-Catalyzed Tandem Synthesis of 2-Acylquinolines from 2-Ethynylanilines and Glyoxals

2021 ◽  
Author(s):  
Guanghui Wang ◽  
Jian Jia ◽  
Gang Liu ◽  
mingwu Yu ◽  
Xiaoxiao Chu ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
One Step ◽  
Tandem Synthesis

An efficient one-step synthesis of 2-acylquinolines by a copper-catalyzed tandem reaction of 2-ethynylanilines with glyoxals in the presence of piperidine has been developed. This new protocol successfully avoids the multi-step...

Gold-catalyzed tandem synthesis of bioactive spiro-dipyrroloquinolines and its application in the one-step synthesis of incargranine B aglycone and seneciobipyrrolidine (I)

2016 ◽  
Vol 3 (3) ◽  
pp. 324-329 ◽  
Author(s):  
Can-Liang Ma ◽  
Xiao-Hua Li ◽  
Xiao-Long Yu ◽  
Xiao-Long Zhu ◽  
Yong-Zhou Hu ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Efficient Access ◽  
One Step ◽  
The One ◽  
Tandem Synthesis

The Au-catalyzed tandem reaction provided simple and efficient access to spiro-dipyrroloquinolines and incargranine B aglycone and (±)-seneciobipyrrolidine (I).

Rhodium-catalysed alkoxylation/acetalization of diazo compounds: one-step synthesis of highly functionalised quaternary carbon centres

2015 ◽  
Vol 51 (77) ◽  
pp. 14505-14508 ◽  
Author(s):  
Jola Pospech ◽  
Alastair J. J. Lennox ◽  
Matthias Beller
Keyword(s):  
Diazo Compounds ◽  
Tandem Reaction ◽  
Quaternary Carbon ◽  
One Step

An intermolecular tandem reaction for the rapid build-up of densely functionalised α-alkoxy-β-oxo-esters has been developed.

scholarly journals One-Step Assembly of Functionalized γ-Butyrolactones from Benzoins or Benzaldehydes via an N-Heterocyclic Carbene Mediated Tandem Reaction.

ChemInform ◽  
2006 ◽  
Vol 37 (1) ◽  
Author(s):  
Wei Ye ◽  
Guanliang Cai ◽  
Zeyang Zhuang ◽  
Xueshun Jia ◽  
Hongbin Zhai
Keyword(s):  
Tandem Reaction ◽  
One Step

In situ generation and trapping of thioimidates: an intermolecular tandem reaction to 4-acylimino-4H-3,1-benzothiazines

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15430-15440 ◽  
Author(s):  
Christian Steinebach ◽  
Anna-Christina Schulz-Fincke ◽  
Gregor Schnakenburg ◽  
Michael Gütschow
Keyword(s):  
Tandem Reaction ◽  
One Step ◽  
In Situ Generation ◽  
Acyl Donors

The proton-catalyzed transformation of 2-thioureidobenzonitriles in the presence of acyl donors provides a convenient one-step entry to 4-acylimino-4H-3,1-benzothiazines.

ChemInform Abstract: Gold-Catalyzed Tandem Synthesis of Bioactive Spiro-Dipyrroloquinolines and Its Application in the One-Step Synthesis of Incargranine B Aglycone and Seneciobipyrrolidine I.

ChemInform ◽  
2016 ◽  
Vol 47 (28) ◽  
Author(s):  
Can-Liang Ma ◽  
Xiao-Hua Li ◽  
Xiao-Long Yu ◽  
Xiao-Long Zhu ◽  
Yong-Zhou Hu ◽  
...  
Keyword(s):  
One Step ◽  
The One ◽  
Tandem Synthesis

scholarly journals Tandem Synthesis of Furanaphthoquinones via Enamines and Evaluation of Their Antiparasitic Effects against Trypanosoma cruzi

2021 ◽  
Author(s):  
Mariana Cardoso ◽  
Luana Forezi ◽  
Acácio de Souza ◽  
Ana Faria ◽  
Raissa Galvão ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Acute Toxicity ◽  
Trypanosoma Cruzi ◽  
Mammalian Cells ◽  
Structural Heterogeneity ◽  
Tandem Reaction ◽  
Cyclic Ketones ◽  
High Potency ◽  
Tandem Synthesis ◽  
General Method

Furanaphthoquinones are well known in medicinal chemistry for exhibiting relevant structural heterogeneity and bioactivities. In this work, it was synthesized a series of furanaphthoquinones through a tandem reaction between lawsone (8) and cyclic ketones in the presence of morpholine. This strategy provides an efficient and general method for synthesizing furanaphthoquinones with activity against the epimastigote form of Trypanosoma cruzi (T. cruzi), the parasite that causes Chagas disease. Compound 9b was the better prototype, and it exhibited high potency for causing parasite death, showed reduced acute toxicity towards mammalian cells, and was capable of rupturing the epimastigote plasma membrane and acting on sterol 14α-demethylase (CYP51). Additionally, 9b reduced trypomastigote viability by 99% after 24 h. Candidate 9b demonstrated the best and most promising profile when bound to CYP51.

One-Step Assembly of Functionalized γ-Butyrolactones from Benzoins or Benzaldehydes via an N-Heterocyclic Carbene-Mediated Tandem Reaction

2005 ◽  
Vol 7 (17) ◽  
pp. 3769-3771 ◽  
Author(s):  
Wei Ye ◽  
Guanliang Cai ◽  
Zeyang Zhuang ◽  
Xueshun Jia ◽  
Hongbin Zhai
Keyword(s):  
Tandem Reaction ◽  
One Step

An Interactive Minicomputer Program for the Indexing and Simulation of Electron Diffraction Patterns

1976 ◽  
Vol 34 ◽  
pp. 542-543
Author(s):  
R.P. Goehner ◽  
W.T. Hatfield ◽  
Prakash Rao
Keyword(s):  
Electron Diffraction ◽  
Real Time ◽  
Pattern Analysis ◽  
Flow Diagram ◽  
Hard Copy ◽  
Time Analysis ◽  
Real Time Analysis ◽  
Transmission Electron ◽  
One Step ◽  
Diffraction Patterns

Computer programs are now available in various laboratories for the indexing and simulation of transmission electron diffraction patterns. Although these programs address themselves to the solution of various aspects of the indexing and simulation process, the ultimate goal is to perform real time diffraction pattern analysis directly off of the imaging screen of the transmission electron microscope. The program to be described in this paper represents one step prior to real time analysis. It involves the combination of two programs, described in an earlier paper(l), into a single program for use on an interactive basis with a minicomputer. In our case, the minicomputer is an INTERDATA 70 equipped with a Tektronix 4010-1 graphical display terminal and hard copy unit.A simplified flow diagram of the combined program, written in Fortran IV, is shown in Figure 1. It consists of two programs INDEX and TEDP which index and simulate electron diffraction patterns respectively. The user has the option of choosing either the indexing or simulating aspects of the combined program.

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Sign in / Sign up

Export Citation Format

Share Document