Biocompatible photoinduced CuAAC using sodium pyruvate

2021 ◽  
Author(s):  
Jaepil Jeong ◽  
Grzegorz Szczepaniak ◽  
Saigopalakrishna S. Yerneni ◽  
Francesca Lorandi ◽  
Hossein Jafari ◽  
...  
Keyword(s):  
Cellular Metabolism ◽  
Sodium Pyruvate ◽  
Buffer Solutions

Sodium pyruvate, a natural intermediate produced during cellular metabolism, is commonly used in buffer solutions and media for biochemical applications. Here we show the use of sodium pyruvate (SP) as...

Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation

2020 ◽  
Vol 20 (7) ◽  
pp. 490-500 ◽  
Author(s):  
Justin S. Becker ◽  
Amir T. Fathi
Keyword(s):  
Genome Structure ◽  
Cellular Metabolism ◽  
Standard Of Care ◽  
Competitive Inhibitor ◽  
Driver Mutations ◽  
New Class ◽  
Regulatory Enzymes ◽  
Idh Mutations ◽  
Genomic Characterization

The genomic characterization of acute myeloid leukemia (AML) by DNA sequencing has illuminated subclasses of the disease, with distinct driver mutations, that might be responsive to targeted therapies. Approximately 15-23% of AML genomes harbor mutations in one of two isoforms of isocitrate dehydrogenase (IDH1 or IDH2). These enzymes are constitutive mediators of basic cellular metabolism, but their mutated forms in cancer synthesize an abnormal metabolite, 2- hydroxyglutarate, that in turn acts as a competitive inhibitor of multiple gene regulatory enzymes. As a result, leukemic IDH mutations cause changes in genome structure and gene activity, culminating in an arrest of normal myeloid differentiation. These discoveries have motivated the development of a new class of selective small molecules with the ability to inhibit the mutant IDH enzymes while sparing normal cellular metabolism. These agents have shown promising anti-leukemic activity in animal models and early clinical trials, and are now entering Phase 3 study. This review will focus on the growing preclinical and clinical data evaluating IDH inhibitors for the treatment of IDH-mutated AML. These data suggest that inducing cellular differentiation is central to the mechanism of clinical efficacy for IDH inhibitors, while also mediating toxicity for patients who experience IDH Differentiation Syndrome. Ongoing trials are studying the efficacy of IDH inhibitors in combination with other AML therapies, both to evaluate potential synergistic combinations as well as to identify the appropriate place for IDH inhibitors within existing standard-of-care regimens.

The Interfacial Behaviour of Mono-, Di-, and Triphosphate of Inosine at the Charged Interface

1996 ◽  
Vol 61 (11) ◽  
pp. 1600-1608
Author(s):  
Mohamed E. Ahmed
Keyword(s):  
Divalent Metal ◽  
Divalent Metal Ions ◽  
Adsorption Parameters ◽  
Buffer Solutions ◽  
Ph Values ◽  
Adsorption Equilibria ◽  
Charged Interface ◽  
Interfacial Behaviour ◽  
Phase Sensitive ◽  
Adsorption Stage

The interfacial behaviour and adsorption equilibria of mono-, di-, and triphosphate of inosine (IMP, IDP, and ITP) were carried out in different buffer solutions by phase-sensitive ac voltammetry at HMDE. The characteristic properties and adsorption parameters of dilute and compact layers were evaluated from the obtained Frumkin isotherm at different pH values. The effect of some divalent metal ions on the adsorption stage and association of the investigated compounds has been studied.

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