Two-photon Fluorogenic Probe Visualizing PGP-1 Activity in Inflammatory Tissue and Serum from Patients

2021 ◽  
Author(s):  
Hua Bai ◽  
Bin Fang ◽  
Xu-Jie Wang ◽  
Wenjing Qin ◽  
Yuhe Chen ◽  
...  

Pyroglutamate Aminopeptidase 1 (PGP-1) changes and distribution in human samples during inflammation are poorly characterized, limiting the understanding of the exact roles of PGP-1 in the metabolism of anti-inflammatory drugs....

2019 ◽  
Vol 55 (76) ◽  
pp. 11358-11361 ◽  
Author(s):  
Ao Jiang ◽  
Guang Chen ◽  
Jie Xu ◽  
Yuxia Liu ◽  
Guanghui Zhao ◽  
...  

A probe for imaging of mitochondrial carboxylesterase and pH has been developed for the visualization of carboxylesterase-mediated acidification in hepatoma cells and hepatic tissues during the administration of antipyretic and anti-inflammatory drugs.


Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.


This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)


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