A Metal-polyphenolic Nanosystem with NIR-II Fluorescence-guided Combined Photothermal Therapy and Radiotherapy

2021 ◽  
Author(s):  
Jie Li ◽  
Wenxi Li ◽  
Lisi Xie ◽  
Wei Sang ◽  
Guohao Wang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Photothermal Therapy ◽  
Tumor Recurrence ◽  
Exogenous Agents ◽  
Tumor Types

Photothermal therapy (PTT) achieves substantive therapeutic progress in certain tumor types without exogenous agents but is hampered by the over-activated inflammatory response or tumor recurrence in some cases. Herein, we...

Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity

2022 ◽  
Author(s):  
Peiying Huang ◽  
Yin Yin Zhu ◽  
Hao Zhong ◽  
Peiling Chen ◽  
Qunying Shi ◽  
...  
Keyword(s):  
Low Temperature ◽  
Tumor Cells ◽  
Stress Responses ◽  
Photothermal Therapy ◽  
Tumor Recurrence ◽  
Antitumor Immunity ◽  
Blood Clearance ◽  
Low Efficiency

The instinctive protective stress responses of tumor cells hamper the low-temperature photothermal therapy (LTPTT), resulting in tumor recurrence and metastasis. The rapid blood clearance and low-efficiency tumor enrichment of nanomedicines...

scholarly journals Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

2019 ◽  
Author(s):  
Takumi Kishimoto ◽  
Nobukazu Fujimoto ◽  
Takeshi Ebara ◽  
Toyonori Omori ◽  
Tetsuya Oguri ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Damage ◽  
Serum Levels ◽  
Pleural Mesothelioma ◽  
Asbestos Fibers ◽  
Chemokine Ligand ◽  
History Of ◽  
Tumor Types ◽  
Study Participants

Abstract Background: Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients. Methods: The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA. Results: Levels of CCL2 were significantly elevated in the serum of patients with advanced MPM patients. Conclusions: Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

scholarly journals The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Sabine Grösch ◽  
Alice V. Alessenko ◽  
Elisabetta Albi
Keyword(s):  
Biological Activity ◽  
Inflammatory Response ◽  
Immune Cells ◽  
Inflammatory Process ◽  
Acute Inflammatory Response ◽  
Exogenous Agents ◽  
The Many

This review provides an overview on components of the sphingolipid superfamily, on their localization and metabolism. Information about the sphingolipid biological activity in cell physiopathology is given. Recent studies highlight the role of sphingolipids in inflammatory process. We summarize the emerging data that support the different roles of the sphingolipid members in specific phases of inflammation: (1) migration of immune cells, (2) recognition of exogenous agents, and (3) activation/differentiation of immune cells.

scholarly journals Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS InflammatoryResponse in Pharynx of Ciona robusta

2021 ◽  
Vol 22 (20) ◽  
pp. 11141
Author(s):  
Aiti Vizzini ◽  
Angela Bonura ◽  
Laura La Paglia ◽  
Antonino Fiannaca ◽  
Massimo La Rosa ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cytochromes P450 ◽  
Mirna Regulation ◽  
Hematopoietic Organ ◽  
Genes Expression ◽  
Exogenous Agents ◽  
Species Specific ◽  
Next Generation Sequencing Ngs ◽  
Post Transcriptional Regulation

Cytochromes P450 (CYP) are enzymes responsible for the biotransformation of most endogenous and exogenous agents. The expression of each CYP is influenced by a unique combination of mechanisms and factors including genetic polymorphisms, induction by xenobiotics, and regulation by cytokines and hormones. In recent years, Ciona robusta, one of the closest living relatives of vertebrates, has become a model in various fields of biology, in particular for studying inflammatory response. Using an in vivo LPS exposure strategy, next-generation sequencing (NGS) and qRT-PCR combined with bioinformatics and in silico analyses, compared whole pharynx transcripts from naïve and LPS-exposed C. robusta, and we provide the first view of cytochrome genes expression and miRNA regulation in the inflammatory response induced by LPS in a hematopoietic organ. In C. robusta, cytochromes belonging to 2B,2C, 2J, 2U, 4B and 4F subfamilies were deregulated and miRNA network interactions suggest that different conserved and species-specific miRNAs are involved in post-transcriptional regulation of cytochrome genes and that there could be an interplay between specific miRNAs regulating both inflammation and cytochrome molecules in the inflammatory response in C. robusta.

scholarly journals Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

2019 ◽  
Author(s):  
Takumi Kishimoto ◽  
Nobukazu Fujimoto ◽  
Takeshi Ebara ◽  
Toyonori Omori ◽  
Tetsuya Oguri ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Damage ◽  
Elevated Serum ◽  
Serum Levels ◽  
Pleural Mesothelioma ◽  
Asbestos Fibers ◽  
Chemokine Ligand ◽  
History Of ◽  
Tumor Types

Abstract Background Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients.Methods The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA.Results Levels of CCL2 were significantly elevated in the serum of the MPM patients, and the increase was dependent on the stage of the disease.Conclusions Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Several, but not all, studies of serum CCL2 levels in patients with other types of cancer also report elevated serum CCL2, and many of these studies report that the increased levels of serum CCL2 are associated with the stage of the disease. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

scholarly journals Pyroelectric Catalysis-based “Nano-lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

2021 ◽  
Author(s):  
Yuchu He ◽  
Zhuo Li ◽  
Cong Cong ◽  
Fei Ye ◽  
Jingyue Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Recurrence ◽  
Interstitial Fluid ◽  
Tumor Proliferation ◽  
Oxygen Species ◽  
Tumor Stem Cells ◽  
Interstitial Pressure ◽  
Tumor Penetration ◽  
Tumor Interstitial Fluid ◽  
Novel Strategy

Abstract Owing to deficiency of lymphatic reflux in the tumor, the retention of tumor interstitial fluid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based “Nano-lymphatic” to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial fluid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration. Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the “Nano-lymphatic” relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence. Our finding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great significance for drug delivery.

scholarly journals Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Takumi Kishimoto ◽  
Nobukazu Fujimoto ◽  
Takeshi Ebara ◽  
Toyonori Omori ◽  
Tetsuya Oguri ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Malignant Pleural Mesothelioma ◽  
Tissue Damage ◽  
Serum Levels ◽  
Pleural Mesothelioma ◽  
Asbestos Fibers ◽  
Chemokine Ligand ◽  
History Of ◽  
Tumor Types ◽  
Study Participants

Abstract Background Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effusions of mesothelioma patients, however, CCL2 has not been examined in the serum of mesothelioma patients. Methods The present study was carried out with 50 MPM patients and 356 subjects who were possibly exposed to asbestos but did not have disease symptoms and 41 healthy volunteers without a history of exposure to asbestos. The levels of CCL2 in the serum of the study participants was determined using ELISA. Results Levels of CCL2 were significantly elevated in the serum of patients with advanced MPM. Conclusions Our findings are consistent with the premise that the CCL2/CCR2 axis and myeloid-derived cells play an important role in MPM and disease progression. Therapies are being developed that target CCL2/CCR2 and tumor resident myeloid cells, and clinical trials are being pursued that use these therapies as part of the treatment regimen. The results of trials with patients with a similar serum CCL2 pattern as MPM patients will have important implications for the treatment of MPM.

scholarly journals Self-Synergistic Effect of Prussian Blue Nanoparticles for Cancer Therapy: Driving Photothermal Therapy and Reducing Hyperthermia-induced Side Effects

2021 ◽  
Author(s):  
Xue Xie ◽  
Wei Gao ◽  
Junnian Hao ◽  
Jianrong Wu ◽  
Xiaojun Cai ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Inflammatory Response ◽  
Photothermal Therapy ◽  
Ros Scavenging ◽  
Uniform Size ◽  
Irreversible Damage ◽  
Anti Inflammatory ◽  
Further Development

Abstract BackgroundsPhotothermal therapy (PTT) inducing localized hyperthermia to kill cancer cells has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during photothermal therapy (PTT) may cause irreversible damage to healthy tissues around the tumor. Simultaneously, hyperthermia can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. How to reduce the undesired side effects remains to be an inevitable problem for the further development of photothermal therapy.ResultsThe spherical mesoporous PBs with uniform size was prepared by an effective hydrothermal method. The yielded PBs exhibits good dispersion and stability in saline with an average hydrodynamic size of about 110 nm. The prepared PBs has a high photothermal conversion efficiency and photothermal stability. Meanwhile, PBs shows the intrinsic ROS scavenging properties (•OH, •OOH, and H2O2) in vitro. The antioxidant and anti-inflammatory effects of PBs have also been evaluated in vivo. Moreover, the toxicity assessment and endoplasmic reticulum (ER) stress-inducing ability show that PBs could not induce an inflammatory response. H&E-staining tissue of major organs show no significant damage, indicating that the good biocompatibility and safety of PBs in vivo. These intrinsic functions of PBs may achieve efficient PTT and simultaneously reduce the side effects induced by PTT.ConclusionThe designed single-component PBs with intrinsic properties simultaneously drive their photothermal-antioxidant effect and photothermal-anti-inflammatory effect to overcome the problem of inflammatory response and heat stress-induced ROS during PTT. The discovery of the inherent function of PBs not only promotes the further clinical translation of PBs, but also promotes the further development of PTT.

Combined photothermal-immunotherapy via poly-tannic acid coated PLGA nanoparticles for cancer treatment

2021 ◽  
Author(s):  
Xingyue Huang ◽  
Xuehao Tian ◽  
Qing Zhang ◽  
Haiyan Hu ◽  
Jia Hui Gao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cancer Treatment ◽  
Tannic Acid ◽  
Photothermal Therapy ◽  
Tumor Recurrence ◽  
Plga Nanoparticles ◽  
Host Immune Responses

Photothermal therapy (PTT) is able to ablate tumors via hyperthermia, while immunotherapy could prevent tumor recurrence and metastasis by activating the host immune responses. Therefore, the combination of PTT and...

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