Immunogenic cell death inducers for enhanced cancer immunotherapy

2021 ◽  
Author(s):  
Yanhua Li ◽  
Xiaohan Liu ◽  
Xia Zhang ◽  
Wei Pan ◽  
Na Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
Immunogenic Cell Death ◽  
Important Method

Inducing immunogenic cell death (ICD) of cancer cells is an important method to improve the immunogenicity of tumor for enhanced cancer immunotherapy. Therefore, we discuss the ICD process and then...

scholarly journals Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1823 ◽  
Author(s):  
Jenny Sprooten ◽  
Pieter De Wijngaert ◽  
Isaure Vanmeerbeek ◽  
Shaun Martin ◽  
Peter Vangheluwe ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
Inflammatory Cell ◽  
Necrotic Cell Death ◽  
Immunogenic Cell Death ◽  
Necrotic Cell ◽  
Cell Death Pathway ◽  
Immune Checkpoint Blockers ◽  
Anticancer Immunity

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain unresponsive to ICBs due to widespread immuno-resistance. To “break” cancer cell-driven immuno-resistance, researchers have long floated the idea of therapeutically facilitating the immunogenicity of cancer cells by disrupting tumor-associated immuno-tolerance via conventional anticancer therapies. It is well appreciated that anticancer therapies causing immunogenic or inflammatory cell death are best positioned to productively activate anticancer immunity. A large proportion of studies have emphasized the importance of immunogenic apoptosis (i.e., immunogenic cell death or ICD); yet, it has also emerged that necroptosis, a programmed necrotic cell death pathway, can also be immunogenic. Emergence of a proficient immune profile for necroptosis has important implications for cancer because resistance to apoptosis is one of the major hallmarks of tumors. Putative immunogenic or inflammatory characteristics driven by necroptosis can be of great impact in immuno-oncology. However, as is typical for a highly complex and multi-factorial disease like cancer, a clear cause versus consensus relationship on the immunobiology of necroptosis in cancer cells has been tough to establish. In this review, we discuss the various aspects of necroptosis immunobiology with specific focus on immuno-oncology and cancer immunotherapy.

A cell membrane vehicle co-delivering sorafenib and doxorubicin remodel the tumor microenvironment and enhance immunotherapy by inducing immunogenic cell death in lung cancer cells

2020 ◽  
Vol 8 (34) ◽  
pp. 7755-7765 ◽  
Author(s):  
Jun Wan ◽  
Jian Wang ◽  
Min Zhou ◽  
Zhanpeng Rao ◽  
Xiean Ling
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
Lung Cancer Cells ◽  
Immunogenic Cell Death ◽  
A Cell

Cancer immunotherapy is a promising approach for cancer therapy but is usually hindered by the inhibition of the tumor microenvironment (TME).

scholarly journals Immunogenic Cell Death-Based Cancer Vaccines

2021 ◽  
Vol 12 ◽  
Author(s):  
Ming-Zhu Jin ◽  
Xi-Peng Wang
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Cancer Immunotherapy ◽  
Adaptive Immunity ◽  
Cancer Vaccines ◽  
Antitumor Immunity ◽  
Immunogenic Cell Death ◽  
Cancer Vaccination ◽  
The Past ◽  
Molecular Patterns

Cancer immunotherapy has achieved great advancement in the past decades. Whereas, its response is largely limited in immunologically cold tumors, in an urgent need to be solve. In recent years, an increasing number of studies have shown that inducing immunogenic cell deaths (ICDs) is an attractive approach to activate antitumor immunity. Upon specific stress, cancer cells undergo ICDs and dying cancer cells release danger associated molecular patterns (DAMPs), produce neoantigens and trigger adaptive immunity. ICDs exert a cancer vaccine-like effect and Inducement of ICDs mimics process of cancer vaccination. In this review, we propose a concept of ICD-based cancer vaccines and summarize sources of ICD-based cancer vaccines and their challenges, which may broaden the understandings of ICD and cancer vaccines in cancer immunotherapy.

scholarly journals Laser nanobubbles induce immunogenic cell death in breast cancer

Nanoscale ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 3644-3653
Author(s):  
Hieu T. M. Nguyen ◽  
Nitesh Katta ◽  
Jessica A. Widman ◽  
Eri Takematsu ◽  
Xu Feng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Dendritic Cell ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cell Activation ◽  
Immunogenic Cell Death ◽  
Dendritic Cell Activation

Laser nanobubbles induce dendritic cell activation in breast cancer cells.

Plasmon‐Driven Catalytic Chemotherapy Augments Cancer Immunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway

2021 ◽  
pp. 2102188
Author(s):  
Yuan Ding ◽  
Zhongquan Sun ◽  
Yong Gao ◽  
Sitong Zhang ◽  
Caixia Yang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Immunotherapy ◽  
Immunogenic Cell Death

Tumor Microenvironment-Triggered In-Situ Cancer Vaccines with Dual Immunogenic Cell Death Inductions for Elevated Antitumor and Antimetastatic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jun Lin ◽  
Binbin Ding ◽  
Pan Zheng ◽  
Dong Li ◽  
Meifang Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Cancer Immunotherapy ◽  
Cancer Vaccines ◽  
High Specificity ◽  
The Body ◽  
Immunogenic Cell Death ◽  
Specific Antigens

Cancer vaccine is to make tumor-specific antigens into vaccines, which then are injected back into the body to activate immune responses for cancer immunotherapy. Despite the high specificity and therapeutic...

A [Pt(cis-1,3-diaminocycloalkane)Cl2] analog exhibits hallmarks typical of immunogenic cell death inducers in model cancer cells

2021 ◽  
pp. 111628
Author(s):  
Vojtěch Novohradsky ◽  
Lenka Markova ◽  
Hana Kostrhunova ◽  
Jana Kasparkova ◽  
James Hoeschele ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Immunogenic Cell Death

Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death

2021 ◽  
Author(s):  
Lvqin Fu ◽  
Xianbin Ma ◽  
Yuantong Liu ◽  
Zhigang Xu ◽  
Zhijun Sun
Keyword(s):  
Cell Death ◽  
Cancer Immunotherapy ◽  
Immunogenic Cell Death

A bifunctional nanomodulator for boosting CpG-mediated cancer immunotherapy

Nanoscale ◽  
2017 ◽  
Vol 9 (37) ◽  
pp. 14236-14247 ◽  
Author(s):  
Zhenzhen Wang ◽  
Yan Zhang ◽  
Zhen Liu ◽  
Kai Dong ◽  
Chaoqun Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Immunotherapy ◽  
Immunogenic Cell Death ◽  
Immunosuppressive Microenvironment

We reported a bifunctional nanomodulator that could induce immunogenic cell death and decrease the immunosuppressive microenvironment to boost CpG-mediated cancer immunotherapy.

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