2,2′-Bipyridine-α,α′-trifluoromethyl-diol ligand: synthesis and application in the asymmetric Et2Zn alkylation of aldehydes
A chiral 2,2′-bipyridine ligand (1) bearing α,α′-trifluoromethyl-alcohols at 6,6′-positions was designed in five steps affording either the R,R or S,S enantiomer with excellent stereoselectivities, i.e. 97% de, >99% ee and >99.5% de, >99.5% ee, respectively.
2017 ◽
Vol 148
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pp. 2051-2059
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1997 ◽
Vol 261
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pp. 175-180
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2014 ◽
Vol 12
(2)
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pp. 223-232
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2009 ◽
Vol 159
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pp. 2075-2080
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