Macrocyclic host molecules with aromatic building blocks: state of art and progress

2021 ◽  
Author(s):  
Qiang Shi ◽  
Xuping Wang ◽  
Bing Liu ◽  
Panyu Qiao ◽  
Jing Li ◽  
...  
Keyword(s):  
Supramolecular Chemistry ◽  
Molecular Design ◽  
Building Blocks ◽  
Host Molecule ◽  
Structural Symmetry ◽  
Host Molecules ◽  
State Of Art ◽  
Guest Chemistry

Macrocyclic host molecule plays the central role in host-guest chemistry and supramolecular chemistry. Highly structural symmetry of macrocyclic host molecules can meet people's pursuit of aesthetics in molecular design, and...

Ionic effects on Supramolecular Hosts: Solvation and Counter-ion Binding in Polar Media

2021 ◽  
Author(s):  
Nicolas Moreno-Gómez ◽  
Edgar Vargas ◽  
Richard Buchner
Keyword(s):  
Aqueous Solution ◽  
Supramolecular Chemistry ◽  
Ion Binding ◽  
Host Molecules ◽  
Counter Ion ◽  
Polar Media ◽  
Counter Ion Binding ◽  
Ionic Effects

For the progress of synthetic supramolecular chemistry in aqueous solution the design of host molecules soluble in this medium is essential. A possible route is the introduction of ionic residues,...

[Si(SiMe3)3]6Ge18M (M = Cu, Ag, Au): metalloid cluster compounds as unusual building blocks for a supramolecular chemistry

2008 ◽  
pp. 4436 ◽  
Author(s):  
Christian Schenk ◽  
Florian Henke ◽  
Gustavo Santiso-Quiñones ◽  
Ingo Krossing ◽  
Andreas Schnepf
Keyword(s):  
Supramolecular Chemistry ◽  
Building Blocks ◽  
Cluster Compounds

Rational Molecular Design of Potent PLK1 PBD Domain-binding Phosphopeptides Using Preferential Amino Acid Building Blocks

2016 ◽  
Vol 13 (8) ◽  
pp. 1103-1110
Author(s):  
Xin-Li Mao ◽  
Kui-Feng Wang ◽  
Feng Zhu ◽  
Zhao-Hu Pan ◽  
Guo-Min Wu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Molecular Design ◽  
Building Blocks ◽  
Rational Molecular Design

Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

2020 ◽  
Vol 8 (31) ◽  
pp. 6739-6752
Author(s):  
Kaiqi Long ◽  
Yuwei Liu ◽  
Yafei Li ◽  
Weiping Wang
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Molecular Design ◽  
Structural Characteristics ◽  
Building Blocks

This review introduces trigonal building blocks and summarizes their structural characteristics, self-assembly ability and biomedical applications.

Tetra- and Octalactam Macrocycles and Catenanes with Exocyclic Metal Coordination Sites: Versatile Building Blocks for Supramolecular Chemistry

2003 ◽  
Vol 9 (6) ◽  
pp. 1332-1347 ◽  
Author(s):  
Xi-you Li ◽  
Jens Illigen ◽  
Martin Nieger ◽  
Steffen Michel ◽  
Christoph A. Schalley
Keyword(s):  
Supramolecular Chemistry ◽  
Building Blocks ◽  
Metal Coordination ◽  
Coordination Sites

Host-guest interactions of cyclodextrins and metalloporphyrins: supramolecular building blocks toward artificial heme proteins

2004 ◽  
Vol 08 (02) ◽  
pp. 125-140 ◽  
Author(s):  
Huchen Zhou ◽  
John T. Groves
Keyword(s):  
Binding Constant ◽  
Molecular Design ◽  
Covalent Binding ◽  
Binding Constants ◽  
Building Blocks ◽  
Binding Pocket ◽  
Axial Ligand ◽  
Pyridyl Nitrogen ◽  
H Nmr ◽  
Self Assembled

Cyclodextrins are versatile building blocks for a variety of macromolecules due to the inclusion complexes that are formed with hydrophobic organic molecules. Cyclodextrin-porphyrin interactions are of particular interest since cyclodextrins can serve as a non-covalent binding pocket while metalloporphyrins could serve as the heme analogs in the construction of heme protein model compounds. Various approaches to the design and assembly of biomimetic porphyrin constructs are compared and contrasted in this minireview with a particular emphasis on self-assembled and porphyrin-cyclodextrin systems. Several recent advances from our laboratories are described in this context. A sensitive fluorescent binding probe, 6A-N-dansyl-permethylated-β-cyclodextrin (Dan-NH-TMCD), was found to form 2:1 complexes with the meso-tetraphenylporphyrins Mn(III)TCPP , Mn(III)TPPS and Mn(III)TF 4 TMAP with high binding constants. A perPEGylated cyclodextrin, heptakis(2,3,6-tri-O-2-(2-(2-methoxyethoxy)ethoxy)ethyl)-β-cyclodextrin (TPCD), has been shown by 1 H NMR spectroscopy to form a 1:1 complex with H 2 TCPP with a binding constant above 108M-1. Such a strong binding constant is the largest found for a 1:1 complex between a monomeric cyclodextrin and a guest. TPCD was also found to bind Mn(III)TCPP with a binding constant of 1.2 × 106 M -1. A novel, self-assembled hemoprotein model, hemodextrin is also described. The molecular design is based on a PEGylated cyclodextrin scaffold that bears both a heme-binding pocket and an axial ligand that binds an iron porphyrin. The binding constant for Fe (III) TPPS (iron(III) meso-tetra(4-sulfonatophenyl)porphyrin) by py-PPCD was determined to be 2 × 106 M -1. The pyridyl nitrogen of py-PPCD was shown to ligate to the iron center by observing signal changes in the Fe(II) -porphyrin 1 H NMR spectrum. This hemodextrin ensemble, a minimalist myoglobin, was shown to bind dioxygen reversibly and to form a stable ferryl species.

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