The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags

2021 ◽  
Author(s):  
Didik Huswo Utomo ◽  
Akari Fujieda ◽  
Kentaro Tanaka ◽  
Momoko Takahashi ◽  
Kentaro Futaki ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Anticancer Drug ◽  
Protein Interactions ◽  
Side Chain ◽  
Protein Protein Interactions ◽  
Affinity Tags ◽  
Promising Strategy ◽  
Anticancer Drug Development ◽  
Aplyronine A

Anticancer drug development inspired by natural products based on protein–protein interactions (PPI) is a promising strategy. We developed structurally-simplified C29–C34 side-chain analogs of aplyronine A (ApA), an antitumor marine macrolide....

scholarly journals Natural products as new antimitotic compounds for anticancer drug development

Clinics ◽  
2018 ◽  
Vol 73 (Suppl 1) ◽  
Author(s):  
CR Paier ◽  
SS Maranhão ◽  
TR Carneiro ◽  
LM Lima ◽  
DD Rocha ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Anticancer Drug ◽  
Anticancer Drug Development

Development of a novel inducer of protein–protein interactions based on aplyronine A

2018 ◽  
Vol 54 (68) ◽  
pp. 9537-9540 ◽  
Author(s):  
Takayuki Ohyoshi ◽  
Atsuhiro Takano ◽  
Mayu Namiki ◽  
Tomotaka Ogura ◽  
Yuto Miyazaki ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Biological Activities ◽  
Side Chain ◽  
Protein Protein Interactions ◽  
Swinholide A ◽  
Aplyronine A

An aplyronine A–swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities.

Applications of liquid biopsy in the Pharmacological Audit Trail for anticancer drug development

2021 ◽  
Author(s):  
Abhijit Pal ◽  
Rajiv Shinde ◽  
Manuel Selvi Miralles ◽  
Paul Workman ◽  
Johann de Bono
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Liquid Biopsy ◽  
Audit Trail ◽  
Anticancer Drug Development

Non-invasive MRS in new anticancer drug development

1992 ◽  
Vol 5 (5) ◽  
pp. 270-272 ◽  
Author(s):  
Paul Workman ◽  
Ross J. Maxwell ◽  
John R. Griffiths
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Non Invasive ◽  
Anticancer Drug Development

Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development

2008 ◽  
Vol 44 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Giuseppe Curigliano ◽  
Gianluca Spitaleri ◽  
Howard J. Fingert ◽  
Filippo de Braud ◽  
Cristiana Sessa ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation ◽  
Anticancer Drug Development

NMR Probing of Protein−Protein Interactions Using Reporter Ligands and Affinity Tags

2004 ◽  
Vol 126 (6) ◽  
pp. 1636-1637 ◽  
Author(s):  
Martin L. Ludwiczek ◽  
Bettina Baminger ◽  
Robert Konrat
Keyword(s):  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Affinity Tags
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