Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobes

2021 ◽  
Author(s):  
Ao Li ◽  
Lingxuan Li ◽  
Xing Liu ◽  
Dongxia Chen ◽  
Yifan Fan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Real Time ◽  
Deep Tissue ◽  
Drug Induced ◽  
Real Time Imaging ◽  
Drug Induced Liver Injury ◽  
19F Mri ◽  
Self Assembled

Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F...

scholarly journals Real Time Identification of Drug-Induced Liver Injury (DILI) through Daily Screening of ALT Results: A Prospective Pilot Cohort Study

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42418 ◽  
Author(s):  
Helmi M'Kada ◽  
Hugo Perazzo ◽  
Mona Munteanu ◽  
Yen Ngo ◽  
Nittia Ramanujam ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Injury ◽  
Real Time ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Real Time Identification

A sensitive upconverting nanoprobe based on signal amplification technology for real-time in situ monitoring of drug-induced liver injury

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 15325-15335
Author(s):  
Lingchang Meng ◽  
Xian Zheng ◽  
Zuguo Zheng ◽  
Zhen Zhao ◽  
Lai Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Real Time ◽  
Signal Amplification ◽  
In Situ Monitoring ◽  
Drug Induced ◽  
Drug Induced Liver Injury

A sensitive upconverting nanoprobe based on signal amplification technology was synthesized for real-time in situ monitoring of drug-induced liver injury.

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Drug induced liver injury associated with Flupirtine in 6 cases

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
C Agne ◽  
K Rifai ◽  
HH Kreipe ◽  
MP Manns ◽  
F Puls
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

WISP1 modulates immune cell infiltration upon drug-induced liver injury (DILI)

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
AB Widera ◽  
L Pütter ◽  
S Leserer ◽  
G Campos ◽  
K Rochlitz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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