Radical-mediated multicomponent cascade reaction for the synthesis of azide-biindole derivatives

2021 ◽  
Author(s):  
Xiaoyu Liu ◽  
Kun He ◽  
Na Gao ◽  
Peiyun Jiang ◽  
Jun Lin ◽  
...  
Keyword(s):  
Free Radical ◽  
Cascade Reaction ◽  
Mechanistic Studies ◽  
One Pot

A radical-mediated, one-pot, multicomponent cascade reaction was developed for the synthesis of azide-biindole derivatives. Mechanistic studies demonstrated that the nitrogen-centred free radical was formed by the reaction of the heterocyclic...

scholarly journals PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

2021 ◽  
pp. 174751982098753
Author(s):  
Xiaofang Wu ◽  
Lei Zhou ◽  
Fangshao Li ◽  
Jing Xiao
Keyword(s):  
Acid Chloride ◽  
Bioactive Molecules ◽  
Mechanistic Studies ◽  
One Pot ◽  
Tert Butyl ◽  
Butyl Esters

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

ChemInform Abstract: Synthesis of Benzo[c]fluorenone Through a One-Pot Cascade Reaction Using Inden-1-one Derivatives.

ChemInform ◽  
2014 ◽  
Vol 45 (24) ◽  
pp. no-no
Author(s):  
Shuyan Zheng ◽  
Hongsheng Tan ◽  
Xiaoguang Zhang ◽  
Chunhui Yu ◽  
Zhengwu Shen
Keyword(s):  
Cascade Reaction ◽  
One Pot

Thermo-sensitivity of hybrid nanogels for specific endogenous hydrogen sulfide detection and efficient flash chill treatment

2021 ◽  
Author(s):  
Xu-hao Sun ◽  
Qiu-bo Wang ◽  
Li Pan ◽  
Yilin Mu ◽  
Xian Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Free Radical ◽  
Precipitation Method ◽  
Carboxyl Group ◽  
One Pot ◽  
Thermo Sensitivity

Thermo-responsive nanogels, Poly (NIPAM-AAM) were prepared by a facile method of free radical one-pot precipitation method based on monomeric N-isopropylacrylamide (NIPAM). At the same time, the surface carboxyl group-modified fluorescent...

First total synthesis of oteromycin utilizing one-pot four-step cascade reaction strategy

2013 ◽  
Vol 54 (6) ◽  
pp. 506-511 ◽  
Author(s):  
Hiromi Uchiro ◽  
Nobuhiro Shionozaki ◽  
Ryo Tanaka ◽  
Hiroyuki Kitano ◽  
Naoki Iwamura ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cascade Reaction ◽  
One Pot

Uncatalyzed diastereoselective synthesis of alkyliminofurochromone-derived benzylmalononitriles via a three-component cascade reaction: competition between Diels–Alder cycloaddition and Michael addition

2021 ◽  
Author(s):  
Mohammad Bagher Teimouri ◽  
Zahra Mokhtare ◽  
Hamid Reza Khavasi
Keyword(s):  
Michael Addition ◽  
Heterocyclic Ring ◽  
Cascade Reaction ◽  
Diels Alder ◽  
Chemical Bonds ◽  
Diastereoselective Synthesis ◽  
Atom Economy ◽  
One Pot

Three new chemical bonds and three stereogenic centres and one heterocyclic ring were assembled stereoselectively in a convenient high atom-economy one-pot operation.

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