ON/OFF metal-triggered molecular tweezers for fullerene recognition

2021 ◽  
Author(s):  
Adriana Sacristán-Martín ◽  
Hector Barbero ◽  
Sergio Ferrero ◽  
Daniel Miguel ◽  
Raúl García-Rodríguez ◽  
...  
Keyword(s):  
Molecular Tweezers

Herein, we report molecular tweezers for fullerene recognition based on 2,2’-bipyridine-bearing corannulene motifs. The syn or anti confirmation can be selected simply by Cu(I) coordination/decoordination, thus controlling the fullerene recognition...

scholarly journals Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Annika Meiners ◽  
Sandra Bäcker ◽  
Inesa Hadrović ◽  
Christian Heid ◽  
Christine Beuck ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Rational Design ◽  
Nuclear Export Signal ◽  
Signal Interference ◽  
Receptor Interaction ◽  
Dual Function ◽  
Experimental Proof ◽  
Molecular Tweezers ◽  
Recognition Element ◽  
Dynamics Simulations

AbstractSurvivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. This protein–protein interaction represents an attractive target in cancer research and therapy. Here, we report a sophisticated strategy addressing Survivin’s nuclear export signal (NES), the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine. These were covalently connected to small peptides resembling the natural, self-complementary dimer interface which largely overlaps with the NES. Several biochemical methods demonstrated sequence-selective NES recognition and interference with the critical receptor interaction. These data were strongly supported by molecular dynamics simulations and multiscale computational studies. Rational design of lysine tweezers equipped with a peptidic recognition element thus allowed to address a previously unapproachable protein surface area. As an experimental proof-of-principle for specific transport signal interference, this concept should be transferable to any protein epitope with a flanking well-accessible lysine.

Molecular Tweezers: Synthesis and Formation of Host-Guest Complexes

2010 ◽  
Vol 2010 (28) ◽  
pp. 5503-5508 ◽  
Author(s):  
Béatrice Legouin ◽  
Maud Gayral ◽  
Philippe Uriac ◽  
Jean-François Cupif ◽  
Nicolas Levoin ◽  
...  
Keyword(s):  
Molecular Tweezers

scholarly journals Molecular Complexation of Arenediazonium Ions by a Calix[4]arene Possessing Two Ester Groups: Molecular Tweezers

2004 ◽  
Vol 53 (6) ◽  
pp. 313-317 ◽  
Author(s):  
Takashi ARIMURA ◽  
Takuya NISHIOKA ◽  
Seiji IDE ◽  
Satoshi KUMAMOTO ◽  
Shigeo MURATA ◽  
...  
Keyword(s):  
Molecular Tweezers ◽  
Molecular Complexation

Using molecular tweezers to move and image nanoparticles

Nanoscale ◽  
2013 ◽  
Vol 5 (10) ◽  
pp. 4070 ◽  
Author(s):  
Haimei Zheng
Keyword(s):  
Molecular Tweezers

Bridged bis-Tröger’s base molecular tweezers as new cavitand family

2009 ◽  
Vol 74 (7-8) ◽  
pp. 1091-1099 ◽  
Author(s):  
Martin Havlík ◽  
Václav Parchaňský ◽  
Petr Bouř ◽  
Vladimír Král ◽  
Bohumil Dolensky
Keyword(s):  
Molecular Tweezers ◽  
Troger's Base

New molecular tweezers based on bis-Tröger’s base with methoxycarbonyl groups on its pincers was prepared. These groups were converted into hydroxymethyl groups, which were interconnected by a linker to give the bridged molecular tweezers, a cavitand. The cavitand was studied and its ability to bind nitrobenzene was compared with similar bis-Tröger’s base molecular tweezers.

Weak bonds between molecular tweezers and their guests

2017 ◽  
Vol 1115 ◽  
pp. 335-343 ◽  
Author(s):  
Marlene Bosquez ◽  
Alejandra Cambray ◽  
Alan Miralrio ◽  
Roxana-Mitzayé del Castillo ◽  
Roberto Salcedo
Keyword(s):  
Molecular Tweezers

scholarly journals A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy

2016 ◽  
Vol 12 ◽  
pp. 125-138 ◽  
Author(s):  
Steven C Zimmerman
Keyword(s):  
Small Molecules ◽  
Supramolecular Chemistry ◽  
Myotonic Dystrophy ◽  
Small Molecule ◽  
Early Life ◽  
Rational Design ◽  
Early Experience ◽  
Therapeutic Agents ◽  
Early Career ◽  
Molecular Tweezers

This review summarizes part of the author’s research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host–guest chemistry. This early experience and interest in intercalation ultimately led to the current efforts to develop small molecule therapeutic agents for myotonic dystrophy using a rational design approach that heavily relies on principles of supramolecular chemistry. How this work was influenced by that of others in the field and the evolution of each area of research is highlighted with selected examples.

scholarly journals Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers

2020 ◽  
Vol 142 (40) ◽  
pp. 17024-17038 ◽  
Author(s):  
Tatjana Weil ◽  
Rüdiger Groß ◽  
Annika Röcker ◽  
Kenny Bravo-Rodriguez ◽  
Christian Heid ◽  
...  
Keyword(s):  
Viral Envelope ◽  
Molecular Tweezers
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