Unexpectedly Rigid Short Peptide Foldamers in which NH-π and CH-π Interactions are Reserved in Solution

2021 ◽  
Author(s):  
Luhan Zhai ◽  
Masayuki Nara ◽  
Yuko Otani ◽  
Tomohiko Ohwada
Keyword(s):  
Short Peptides ◽  
Short Peptide ◽  
Π Interactions

NH-π and CH-π interactions, due to its weak character, are not easily to be identified in solution. We report a group of isolable short peptides with stable folds, in which...

scholarly journals A Global Review on Short Peptides: Frontiers and Perspectives

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 430
Author(s):  
Vasso Apostolopoulos ◽  
Joanna Bojarska ◽  
Tsun-Thai Chai ◽  
Sherif Elnagdy ◽  
Krzysztof Kaczmarek ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Targeted Delivery ◽  
Swot Analysis ◽  
Functional Materials ◽  
Great Promise ◽  
Short Peptides ◽  
Altered Peptide Ligands ◽  
Short Peptide ◽  
Domains Of Life

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.

scholarly journals Identification and Antimicrobial Activity of Medium-Sized and Short Peptides from Yellowfin Tuna (Thunnus albacares) Simulated Gastrointestinal Digestion

Foods ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1185
Author(s):  
Andrea Cerrato ◽  
Anna Laura Capriotti ◽  
Federico Capuano ◽  
Chiara Cavaliere ◽  
Angela Michela Immacolata Montone ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Phase ◽  
Model Organism ◽  
Graphitized Carbon Black ◽  
Yellowfin Tuna ◽  
Short Peptides ◽  
Gastrointestinal Digestion ◽  
Exact Mass ◽  
Short Peptide ◽  
Simulated Gastrointestinal Digestion

Due to the rapidly increasing resistance to conventional antibiotics, antimicrobial peptides are emerging as promising novel drug candidates. In this study, peptide fragments were obtained from yellowfin tuna muscle by simulated gastrointestinal digestion, and their antimicrobial activity towards Gram-positive and Gram-negative bacteria was investigated. In particular, the antimicrobial activity of both medium- and short-sized peptides was investigated by using two dedicated approaches. Medium-sized peptides were purified by solid phase extraction on C18, while short peptides were purified thanks to a graphitized carbon black sorbent. For medium-sized peptide characterization, a peptidomic strategy based on shotgun proteomics analysis was employed, and identification was achieved by matching protein sequence database by homology, as yellowfin tuna is a non-model organism, leading to the identification of 403 peptides. As for short peptide sequences, an untargeted suspect screening approach was carried out by means of an inclusion list presenting the exact mass to charge ratios (m/z) values for all di-, tri- and tetrapeptides. In total, 572 short sequences were identified thanks to a customized workflow dedicated to short peptide analysis implemented on Compound Discoverer software.

scholarly journals Photoactive properties of supramolecular assembled short peptides

2019 ◽  
Vol 48 (16) ◽  
pp. 4387-4400 ◽  
Author(s):  
Bingbing Sun ◽  
Kai Tao ◽  
Yi Jia ◽  
Xuehai Yan ◽  
Qianli Zou ◽  
...  
Keyword(s):  
Optical Properties ◽  
Short Peptides ◽  
Short Peptide ◽  
Review Current ◽  
Advanced Applications

In this review, current studies on the optical properties and modulation of photoactive short peptide self-assemblies, as well as their diverse advanced applications, are summarized.

Amphiphilic short peptide modulated wormlike micelle formation with pH and metal ion dual-responsive properties

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 95604-95612 ◽  
Author(s):  
Dong Wang ◽  
Yawei Sun ◽  
Meiwen Cao ◽  
Jiqian Wang ◽  
Jingcheng Hao
Keyword(s):  
Metal Ion ◽  
Micelle Formation ◽  
Wormlike Micelles ◽  
Short Peptides ◽  
Short Peptide ◽  
Dual Responsive ◽  
Wormlike Micelle

Amphiphilic short peptides (ASPs) and surfactants (C14DMAO) were employed to prepare dual-responsive wormlike micelles.

scholarly journals SPA: Short peptide analyzer of intrinsic disorder status of short peptides

2010 ◽  
Vol 15 (6) ◽  
pp. 635-646 ◽  
Author(s):  
Bin Xue ◽  
Wei-Lun Hsu ◽  
Jun-Ho Lee ◽  
Hua Lu ◽  
A. Keith Dunker ◽  
...  
Keyword(s):  
Intrinsic Disorder ◽  
Short Peptides ◽  
Short Peptide
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