Stereoselective synthesis of highly functionalized (Z)-chloroalkene dipeptide isosteres containing an α,α-disubstituted amino acid

2021 ◽  
Author(s):  
Yuki Kodama ◽  
Saki Imai ◽  
Junko Fujimoto ◽  
Kohei Sato ◽  
Nobuyuki Mase ◽  
...  
Keyword(s):  
Amino Acid ◽  
Stereoselective Synthesis ◽  
Quaternary Carbon ◽  
Disubstituted Amino Acid

Described here is the first stereoselective synthesis of highly functionalized chloroalkene dipeptide isosteres containing an α,α-disubstituted amino acid (ααAA). This synthesis requires the construction of a quaternary carbon center, and...

Highly Stereoselective Synthesis of Optically Pure C-Aryl Imines from α-L-Amino Acid Methyl Esters.

ChemInform ◽  
2004 ◽  
Vol 35 (17) ◽  
Author(s):  
Antonella Leggio ◽  
Adolfo Le Pera ◽  
Angelo Liguori ◽  
Anna Napoli ◽  
Claudio Romeo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Stereoselective Synthesis ◽  
Methyl Esters ◽  
Acid Methyl ◽  
Optically Pure ◽  
Amino Acid Methyl Esters

4-Aminopiperidine-4-carboxylic Acid:  A Cyclic α,α-Disubstituted Amino Acid for Preparation of Water-Soluble Highly Helical Peptides

1996 ◽  
Vol 61 (22) ◽  
pp. 7650-7651 ◽  
Author(s):  
Christopher L. Wysong ◽  
T. Scott Yokum ◽  
Guillermo A. Morales ◽  
Rebekah L. Gundry ◽  
Mark L. McLaughlin ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Water Soluble ◽  
Helical Peptides ◽  
Disubstituted Amino Acid

Asymmetric Trienamine Catalysis for the Construction of Structurally Rigid Cyclic α,α-Disubstituted Amino Acid Derivatives

2011 ◽  
Vol 17 (33) ◽  
pp. 9032-9036 ◽  
Author(s):  
Hao Jiang ◽  
Björn Gschwend ◽  
Łukasz Albrecht ◽  
Signe Grann Hansen ◽  
Karl Anker Jørgensen
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Disubstituted Amino Acid

Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides

Tetrahedron ◽  
2015 ◽  
Vol 71 (15) ◽  
pp. 2241-2245 ◽  
Author(s):  
Hiroko Yamashita ◽  
Yosuke Demizu ◽  
Takashi Misawa ◽  
Takuji Shoda ◽  
Masaaki Kurihara
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Conformational Properties ◽  
Disubstituted Amino Acid

Preparation of Cyclic β-Amino Acid Derivatives with Quaternary Carbon Center via a Radical Addition-Cyclization Sequence

Heterocycles ◽  
2014 ◽  
Vol 89 (1) ◽  
pp. 143 ◽  
Author(s):  
Okiko Miyata ◽  
Norihiko Takeda ◽  
Masafumi Ueda ◽  
Seiko Kajisa ◽  
Kenji Matsuno ◽  
...  
Keyword(s):  
Amino Acid ◽  
Radical Addition ◽  
Amino Acid Derivatives ◽  
Quaternary Carbon
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