A Turn-on Probe for Detecting Antituberculotic Drug-induced Liver Injury in Mice via NIR-II Fluorescence/Optoacoustic Imaging

2021 ◽  
Author(s):  
Longqi Chen ◽  
Junjie Chen ◽  
Yichang Fang ◽  
Fang Zeng ◽  
Shuizhu Wu
Keyword(s):  
Infectious Disease ◽  
Liver Injury ◽  
Causes Of Death ◽  
Standard Treatment ◽  
Drug Induced ◽  
Optoacoustic Imaging ◽  
Drug Induced Liver Injury ◽  
Turn On

Standard treatment for tuberculosis (TB), an infectious disease and one of the top ten causes of death worldwide, usually lasts for a long term. And the antituberculotic-drug-induced liver injury has...

scholarly journals Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism

2020 ◽  
Vol 2020 ◽  
pp. 1-12 ◽  
Author(s):  
Ayan Biswas ◽  
Suman Santra ◽  
Debasree Bishnu ◽  
Gopal Krishna Dhali ◽  
Abhijit Chowdhury ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Hepatic Fibrosis ◽  
Stellate Cell ◽  
Progressive Increase ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Stress Dependent ◽  
Liver Collagen

Background & Aims. Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has been also incriminated in chronic DILI. We sought evidence of the production of hepatic fibrosis on long-term INH-RMP treatment through experiments in BALB/c mice exposed to INH-RMP. Methods. A combined dose of INH (50 mg) and RMP (100 mg) per kg body weight per day was administered to mice by oral gavage, 6 days a week, for 4 to 24 weeks for the assessment of liver injury, oxidative stress, and development of hepatic fibrosis, including demonstration of changes in key fibrogenesis linked pathways and mediators. Results. Progressive increase in markers of hepatic stellate cell (HSC) activation associated with changes in matrix turnover was observed between 12 and 24 weeks of INH-RMP treatment along with the elevation of liver collagen content and significant periportal fibrosis. These were associated with concurrent apoptosis of the hepatocytes, increase in hepatic cytochrome P450 2E1 (CYP2E1), NADPH oxidase (NOX) activity, and development of hepatic oxidative stress. Conclusions. INH-RMP can activate HSC through generation of NOX-mediated oxidative stress, leading to the development of liver fibrosis.

scholarly journals Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid

2017 ◽  
Vol 11 (2) ◽  
pp. 440-445 ◽  
Author(s):  
Jenny Sarah Schneider ◽  
Matteo Montani ◽  
Felix Stickel
Keyword(s):  
Liver Disease ◽  
Zoledronic Acid ◽  
Side Effects ◽  
Liver Injury ◽  
Drug Reactions ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
First Case ◽  
Alternative Drugs

Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.

scholarly journals Long-Term Outcomes After Drug-Induced Liver Injury

2018 ◽  
Vol 17 (3) ◽  
pp. 292-299 ◽  
Author(s):  
Paul H. Hayashi ◽  
Einar S. Bjornsson
Keyword(s):  
Liver Injury ◽  
Long Term Outcomes ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Long-term follow-up of patients with mild to moderate drug-induced liver injury

2007 ◽  
Vol 26 (1) ◽  
pp. 79-85 ◽  
Author(s):  
E. BJÖRNSSON ◽  
E. KALAITZAKIS ◽  
V. AV KLINTEBERG ◽  
N. ALEM ◽  
R. OLSSON
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Long Term Follow Up

scholarly journals Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

2018 ◽  
Vol 93 (2) ◽  
pp. 519-532 ◽  
Author(s):  
Laia Tolosa ◽  
Nuria Jiménez ◽  
María Pelechá ◽  
José V. Castell ◽  
Mª José Gómez-Lechón ◽  
...  
Keyword(s):  
Liver Injury ◽  
Human Hepatocytes ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry

Hepatology ◽  
2006 ◽  
Vol 44 (6) ◽  
pp. 1581-1588 ◽  
Author(s):  
Raúl J. Andrade ◽  
M. Isabel Lucena ◽  
Neil Kaplowitz ◽  
Beatriz García-Muņoz ◽  
Yolanda Borraz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Long Term Follow Up

scholarly journals Drug-induced liver injury due to the long-term oral administration of rosuvastatin

2015 ◽  
Vol 127 (3) ◽  
pp. 219-222
Author(s):  
Ayano Oonishi ◽  
Kazuya Kariyama ◽  
Akiko Wakuta ◽  
Mamoru Nishimura ◽  
Kazuhiro Nouso
Keyword(s):  
Liver Injury ◽  
Oral Administration ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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