Asymmetric construction of six vicinal stereogenic centers on hexahydroxanthones via organocatalytic one-pot reactions

2021 ◽  
Author(s):  
Min Zhang ◽  
Xue-Wen He ◽  
Ya Xiong ◽  
Xiong Zuo ◽  
Wei Zhou ◽  
...  
Keyword(s):  
One Pot ◽  
Efficient Access ◽  
Stereogenic Centers ◽  
Decarboxylation Reaction

Inspired by the chemistry and biology of hexahydroxanthones, herein we report an organocatalytic Michael-Michael-Aldol-decarboxylation reaction that provides efficient access to biologically interesting fully substituted hexahydroxanthones bearing six contiguous stereogenic centers...

Bi(OTf)3-Catalyzed Diastereoselective One-Pot Synthesis of 1,3-Diamines with Three Continuous Stereogenic Centers

2018 ◽  
Vol 83 (19) ◽  
pp. 12007-12022 ◽  
Author(s):  
Juliette Halli ◽  
Philipp Kramer ◽  
Jennifer Grimmer ◽  
Michael Bolte ◽  
Georg Manolikakes
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Stereogenic Centers

Stereocontrolled construction of six vicinal stereogenic centers on a hexahydroxanthone framework through a formal [2+1+3] annulation

2019 ◽  
Vol 55 (93) ◽  
pp. 14003-14006 ◽  
Author(s):  
Shun-Qin Chang ◽  
Xiong Zou ◽  
Yi Gong ◽  
Xue-Wen He ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
Stereogenic Centers

The first example of a bifunctional donor–donor 3C synthon formed in situ from an activated methine with nitromethane through a [2+1] Michael addition, further directing a one-pot organocascade Michael/Henry cycloaddition was developed.

ChemInform Abstract: Recyclable Organocatalyst-Promoted One-Pot Michael/Aza-Henry/Lactamization Reactions for Fluorinated 2-Piperidinones Bearing Four Stereogenic Centers.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Xin Huang ◽  
Kenny Pham ◽  
Xiaofeng Zhang ◽  
Wen-Bin Yi ◽  
Jeremy H. Hyatt ◽  
...  
Keyword(s):  
One Pot ◽  
Stereogenic Centers

One-Pot Asymmetric Synthesis of β-Cyanohydroxymethyl α-Amino Acid Derivatives:  Formation of Three Contiguous Stereogenic Centers

2002 ◽  
Vol 4 (25) ◽  
pp. 4519-4522 ◽  
Author(s):  
Shin-ichi Watanabe ◽  
Armando Córdova ◽  
Fujie Tanaka ◽  
Carlos F. Barbas
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Stereogenic Centers

scholarly journals An efficient access to the synthesis of novel 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives

2012 ◽  
Vol 8 ◽  
pp. 1849-1857 ◽  
Author(s):  
Wentao Gao ◽  
Guihai Lin ◽  
Yang Li ◽  
Xiyue Tao ◽  
Rui Liu ◽  
...  
Keyword(s):  
Polyphosphoric Acid ◽  
Reaction Times ◽  
Easy Access ◽  
Substituted Phenols ◽  
Acylation Reaction ◽  
One Pot ◽  
Cerium Ammonium Nitrate ◽  
Starting Compound ◽  
Efficient Access ◽  
Cerium Ammonium

An efficient access to the tetracyclic-fused quinoline systems, 12-phenylbenzo[6,7]oxepino[3,4-b]quinolin-13(6H)-one derivatives 4a–l, is described, involving the intramolecular Friedel–Crafts acylation reaction of 2-(phenoxymethyl)-4-phenylquinoline-3-carboxylic acid derivatives 3a–l aided by the treatment with PPA (polyphosphoric acid) or Eaton’s reagent. The required starting compound (2) was obtained by Friedländer reaction of 2-aminobenzophenone (1) with 4-chloroethylacetoacetate by using CAN (cerium ammonium nitrate, 10 mol %) as catalyst at room temperature. The substrates 3a–l were prepared through one-pot reaction of ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate (2) and substituted phenols. Our developed strategy, involving a three-step route, offers easy access to tetracyclic-fused quinoline systems in short reaction times, and the products are obtained in moderate to good yields.

Palladium-catalyzed one-pot cycloaddition reactions of thioureas with 3H-indol-3-ones generated in situ from 2-alkynyl arylazides: rapid and efficient access to imidazoloindolines

2020 ◽  
Vol 7 (21) ◽  
pp. 3480-3485
Author(s):  
Ping Li ◽  
Boyu Zhu ◽  
Yao Xu ◽  
Zhiqiang Zhou ◽  
Guiwen Hu ◽  
...  
Keyword(s):  
Cycloaddition Reactions ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Efficient Access ◽  
Palladium Catalyzed

An efficient palladium-catalyzed one-pot synthesis of imidazoloindolines from 2-alkynyl arylazides under mild reaction conditions has been described.

Sign in / Sign up

Export Citation Format

Share Document