Photo-uncaging a Ru(II) Intercalator via Photodecomposition of a Bridged Mn(I) PhotoCORM

2021 ◽  
Author(s):  
Rachael N Pickens ◽  
Grace L Judd ◽  
Jessica K White
Keyword(s):  
Dna Intercalator

A Ru(II) intercalating complex capped with a Mn(I) photoCORM allows for a new mode of DNA intercalator delivery. The steric bulk of the Mn(I) photoCORM inhibits intercalation in the dark,...

FRET-Based Probe for High-Throughput DNA Intercalator Drug Discovery and In Vivo Imaging

ACS Sensors ◽  
2021 ◽  
Author(s):  
Chandrashekhar U. Murade ◽  
Samata Chaudhuri ◽  
Ibtissem Nabti ◽  
Hala Fahs ◽  
Fatima S. M. Refai ◽  
...  
Keyword(s):  
Drug Discovery ◽  
High Throughput ◽  
In Vivo Imaging ◽  
Dna Intercalator

Scanometric analysis of DNA microarrays using DNA intercalator-conjugated gold nanoparticles

2012 ◽  
Vol 48 (61) ◽  
pp. 7601 ◽  
Author(s):  
Hyunmin Cho ◽  
Juyeon Jung ◽  
Bong Hyun Chung
Keyword(s):  
Gold Nanoparticles ◽  
Dna Microarrays ◽  
Dna Intercalator

scholarly journals Femtosecond dynamics of the DNA intercalator ethidium and electron transfer with mononucleotides in water

1999 ◽  
Vol 96 (4) ◽  
pp. 1187-1192 ◽  
Author(s):  
T. Fiebig ◽  
C. Wan ◽  
S. O. Kelley ◽  
J. K. Barton ◽  
A. H. Zewail
Keyword(s):  
Electron Transfer ◽  
Dna Intercalator ◽  
Femtosecond Dynamics

Synthesize and multi-spectroscopic studies of zinc-naproxen nanodrug as DNA intercalator agent

2021 ◽  
pp. 114454
Author(s):  
Ali Nematollahzadeh ◽  
Zeinab Mirzaei-Kalar ◽  
Hoda Abolhasani ◽  
Aziz Babapoor
Keyword(s):  
Spectroscopic Studies ◽  
Dna Intercalator

scholarly journals Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

2020 ◽  
Vol 16 ◽  
pp. 2201-2211
Author(s):  
Poulami Jana ◽  
Filip Šupljika ◽  
Carsten Schmuck ◽  
Ivo Piantanida
Keyword(s):  
Thermal Denaturation ◽  
Major Groove ◽  
Groove Binding ◽  
Dna Intercalator ◽  
Dna Minor Groove ◽  
Ph Values ◽  
Naphthalene Diimide ◽  
Threading Intercalation ◽  
Neutral Conditions ◽  
Pendant Arms

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading intercalation into ds-DNAs only at pH 5, while at neutral conditions (pH 7) NDI-GCP2 switched to the DNA minor groove binding. Intriguingly, NDI-GCP2 was at both pH values studied bound to the ds-RNA major groove, still showing a higher affinity and thermal denaturation effect at pH 5 due to GCP protonation. At excess over the DNA/RNA conjugate NDI-GCP2 showed also aggregation along the ds-polynucleotide and AFM and DLS demonstrated that NDI-GCP2 has pronounced ds-DNA condensation ability.

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