Copper(II) Mediated ortho C-H Alkoxylation of Aromatic Amines using Organic Peroxides: Efficient Synthesis of Hindered Ethers

2021 ◽  
Author(s):  
Subhash Chandra Ghosh ◽  
Souvik Sarkar ◽  
Tapan Sahoo ◽  
Chiranjit Sen
Keyword(s):  
Aromatic Amines ◽  
Medicinal Chemistry ◽  
Organic Peroxides ◽  
Aryl Ether ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Ether Bond ◽  
Huge Challenge

Synthesis of hindered alkyl aryl ether derivatives (R-O-Ar) remains a huge challenge and highly desirable in organic and medicinal chemistry because extensive substitution on the ether bond prevents the undesired...

Alkyl Aryl Ether Bond Formation with PhenoFluor

2015 ◽  
Vol 127 (19) ◽  
pp. 5754-5757 ◽  
Author(s):  
Xiao Shen ◽  
Constanze N. Neumann ◽  
Claudia Kleinlein ◽  
Nathaniel W. Goldberg ◽  
Tobias Ritter
Keyword(s):  
Bond Formation ◽  
Aryl Ether ◽  
Alkyl Aryl ◽  
Ether Bond

scholarly journals Alkyl Aryl Ether Bond Formation with PhenoFluor

2015 ◽  
Vol 54 (19) ◽  
pp. 5662-5665 ◽  
Author(s):  
Xiao Shen ◽  
Constanze N. Neumann ◽  
Claudia Kleinlein ◽  
Nathaniel W. Goldberg ◽  
Tobias Ritter
Keyword(s):  
Bond Formation ◽  
Aryl Ether ◽  
Alkyl Aryl ◽  
Ether Bond

Simple and efficient synthesis of 4H-3,1-benzoxazines from 2-bromomethylphenyl isocyanate and amines

1990 ◽  
Vol 55 (3) ◽  
pp. 752-760 ◽  
Author(s):  
Jozef Gonda ◽  
Mariana Barnikol
Keyword(s):  
Elemental Analysis ◽  
Spectral Methods ◽  
Aromatic Amines ◽  
Sodium Hydrogen Carbonate ◽  
Sodium Hydride ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Sodium Hydrogen ◽  
Radical Bromination ◽  
Hydrogen Carbonate

Reaction of 2-bromomethylphenyl isocyanate (II; prepared by radical bromination of 2-tolyl isocyanate with N-bromsuccinimide) with aliphatic and aromatic amines takes place on the NCO group under formation of stable N-alkyl(aryl)-N'-(2-bromomethylphenyl)ureas III. On treatment with sodium hydrogen carbonate in water or sodium hydride in N,N-dimethylformamide, the ureas III are cyclized to give 2-alkyl(aryl)amino-4H-3,1-benzoxazines IV in good yields. Reaction of isocyanate II with alcohols leads to alkyl 2-bromomethylphenyl carbamates. Structure of the synthesized compounds has been proven by spectral methods and elemental analysis.

ChemInform Abstract: Alkyl Aryl Ether Bond Formation with PhenoFluor.

ChemInform ◽  
2015 ◽  
Vol 46 (38) ◽  
pp. no-no
Author(s):  
Xiao Shen ◽  
Constanze N. Neumann ◽  
Claudia Kleinlein ◽  
Nathaniel W. Goldberg ◽  
Tobias Ritter
Keyword(s):  
Bond Formation ◽  
Aryl Ether ◽  
Alkyl Aryl ◽  
Ether Bond

scholarly journals Microwave-assisted Efficient Synthesis of Alliodorin and (±)-Curcuhydroquinone

1999 ◽  
Vol 23 (2) ◽  
pp. 164-165
Author(s):  
Goverdhan L. Kad ◽  
Anupam Khurana ◽  
Vasundhara Singh ◽  
Jasvinder Singh
Keyword(s):  
Grignard Reagents ◽  
Methyl Groups ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Microwave Assisted ◽  
Aryl Bromides ◽  
Key Steps

Terpenoids 1 and 2 have been synthesized from readily available starting materials using Li2CuCI4-catalysed coupling of Grignard reagents with alkyl/aryl bromides and microwave-assisted oxidation of allylic methyl groups, using SeO2/ButOOH adsorbed over SiO2 as key steps.

Synthesis and photophysical properties of 5-(3''-alkyl/aryl-amino-1''-azaindolizin-2''-yl)-2'-deoxyuridines

2021 ◽  
Author(s):  
Sandeep Kumar ◽  
Sumit Kumar ◽  
Jyotirmoy Maity ◽  
Banty Kumar ◽  
Shilpika Bali ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Efficient Synthesis ◽  
Alkyl Aryl ◽  
Gbb Reaction

Groebke-Blackburn-Bienayame (GBB) reaction has been used for the efficient synthesis of novel fluorescent 5-azaindolizino-2'-deoxyuridines starting from commercially available thymidine following two strategies. Thus, thymidine was converted to diacetylthymidine, which on...

Transition-Metal-Catalyzed Transformation of Sulfonates via S–O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether

2019 ◽  
Vol 21 (22) ◽  
pp. 8879-8883 ◽  
Author(s):  
Xuemeng Chen ◽  
Xue Xiao ◽  
Haotian Sun ◽  
Yue Li ◽  
Haolin Cao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Bond Cleavage ◽  
Aryl Ether ◽  
Alkyl Aryl ◽  
Diaryl Ether ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals Selective Cleavage of Lignin β-O-4 Aryl Ether Bond by β-Etherase of the White-Rot Fungus Dichomitus squalens

2018 ◽  
Vol 6 (3) ◽  
pp. 2878-2882 ◽  
Author(s):  
Mila Marinović ◽  
Paula Nousiainen ◽  
Adiphol Dilokpimol ◽  
Jussi Kontro ◽  
Robin Moore ◽  
...  
Keyword(s):  
White Rot ◽  
White Rot Fungus ◽  
Aryl Ether ◽  
Ether Bond ◽  
Dichomitus Squalens
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