Recent Advances in Chiral Discrimination on Host-guest Functionalized Interfaces

2021 ◽  
Author(s):  
Weiwei Xu ◽  
Ming Cheng ◽  
Siyun Zhang ◽  
Qifa Wu ◽  
Zhuo Liu ◽  
...  
Keyword(s):  
Supramolecular Chemistry ◽  
Biological Systems ◽  
Enantiomeric Separation ◽  
Chiral Discrimination ◽  
Biochemical Sensors ◽  
Recent Advances ◽  
Functionalized Interfaces

Chiral discrimination has gained much focus in supramolecular chemistry, since it is one of the fundamental processes in biological systems, enantiomeric separation and biochemical sensors. Though most of the biochemical...

scholarly journals Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

2021 ◽  
Vol 50 (2) ◽  
pp. 702-734
Author(s):  
Luling Wu ◽  
Jihong Liu ◽  
Ping Li ◽  
Bo Tang ◽  
Tony D. James
Keyword(s):  
Small Molecule ◽  
Biological Systems ◽  
Two Photon ◽  
Small Molecule Probes ◽  
Recent Advances ◽  
Design Construction

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes.

Chiral separation and analysis of antifungal drugs by chromatographic and electromigration techniques: Results achieved in 2010–2020

2021 ◽  
Vol 40 (1) ◽  
pp. 220-252
Author(s):  
Giovanni D’Orazio ◽  
Chiara Fanali ◽  
Chiara Dal Bosco ◽  
Alessandra Gentili ◽  
Salvatore Fanali
Keyword(s):  
Gas Chromatography ◽  
Pharmaceutical Industry ◽  
State Of The Art ◽  
Stationary Phases ◽  
Enantiomeric Separation ◽  
Antifungal Drugs ◽  
Chiral Discrimination ◽  
Food Science ◽  
Industry Environment ◽  
Metabolic Activities

Abstract The determination and separation of enantiomers is an interesting and important topic of research in various fields, e.g., biochemistry, food science, pharmaceutical industry, environment, etc. Although these compounds possess identical physicochemical properties, a pair of enantiomers often has different pharmacological, toxicological, and metabolic activities. For this reason, chiral discrimination by using chromatographic and electromigration techniques has become an urgent need in the pharmaceutical field. This review intends to offer the “state of the art” about the separation of chiral antifungal drugs and several related precursors by both liquid and gas chromatography, as well as electromigration methods. This overview is organized into two sections. The first one describes general considerations on chiral antifungal drugs. The second part deals with the main analytical methods for the enantiomeric discrimination of these drugs, including a brief description of chiral selectors and stationary phases. Moreover, many recent applications attesting the great interest of analytical chemists in the field of enantiomeric separation are presented.

Therapeutic properties of organotin complexes with reference to their structural and environmental features

2017 ◽  
Vol 37 (2) ◽  
pp. 51-70 ◽  
Author(s):  
Muhammad Iqbal ◽  
Saqib Ali ◽  
Ali Haider ◽  
Nasir Khalid
Keyword(s):  
Mode Of Action ◽  
Therapeutic Potential ◽  
Biological Systems ◽  
Structural Features ◽  
Present Review ◽  
Environmental Features ◽  
Recent Advances ◽  
Target Sites ◽  
Therapeutic Properties ◽  
Modes Of Interaction

AbstractOrganotin complexes are being extensively studied and screened for their therapeutic potential. Although many recent advances and achievements in this field have been made, the exact mode of action of these complexes is yet to be unveiled. In the present review, an attempt has been made to correlate the therapeutic properties of organotin complexes with their structural features and the environment in which these interact with biological systems. The mechanism, various modes of interaction with biological systems, and physiological target sites of organotin complexes have been highlighted as well.

scholarly journals Optical Conveyor Belts for Chiral Discrimination: Influence of De-Phasing Parameter

2019 ◽  
Vol 9 (7) ◽  
pp. 1304
Author(s):  
Luis Carretero ◽  
Pablo Acebal ◽  
Salvador Blaya
Keyword(s):  
Numerical Analysis ◽  
Gaussian Beam ◽  
Enantiomeric Separation ◽  
Conveyor Belt ◽  
Separation Distance ◽  
Chiral Discrimination ◽  
Optimum Range ◽  
Conveyor Belts ◽  
Range Of Values ◽  
Maximum Separation

A numerical analysis is carried out of the influence of the de-phasing parameter of anoptical conveyor belt in the enantiomeric separation. The optical conveyor belt is obtained by theinterference of a Laguerre Gaussian and a Gaussian beam with different beam waists, which aretemporally de-phased. In order to obtain the maximum separation distance between enantiomers,we calculate the optimum range of values of the de-phasing parameter.

scholarly journals Recent advances in the analysis of polysialic acid from complex biological systems

2019 ◽  
Vol 224 ◽  
pp. 115145 ◽  
Author(s):  
Xiaoxiao Guo ◽  
Sara M. Elkashef ◽  
Paul M. Loadman ◽  
Laurence H. Patterson ◽  
Robert A. Falconer
Keyword(s):  
Biological Systems ◽  
Polysialic Acid ◽  
Recent Advances

ATR-FTIR spectroscopic imaging: recent advances and applications to biological systems

The Analyst ◽  
2013 ◽  
Vol 138 (7) ◽  
pp. 1940 ◽  
Author(s):  
Sergei G. Kazarian ◽  
K. L. Andrew Chan
Keyword(s):  
Biological Systems ◽  
Spectroscopic Imaging ◽  
Recent Advances

scholarly journals Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 150
Author(s):  
Geeta A. Zalmi ◽  
Ratan W. Jadhav ◽  
Harshad A. Mirgane ◽  
Sheshanath V. Bhosale
Keyword(s):  
Drug Delivery ◽  
Supramolecular Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Active Materials ◽  
Aggregation Induced Emission ◽  
Fluorescent Material ◽  
Recent Advances ◽  
To Come

The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ) which is the most detrimental process thereby making AIE an important and promising aspect in various fields of fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. In this review, we have discussed insights and explored recent advances that are being made in AIE active materials and their application in sensing, biological cell imaging, and drug delivery systems, and, furthermore, we explored AIE active fluorescent material as a building block in supramolecular chemistry. Herein, we focus on various AIE active molecules such as tetraphenylethylene, AIE-active polymer, quantum dots, AIE active metal-organic framework and triphenylamine, not only in terms of their synthetic routes but also we outline their applications. Finally, we summarize our view of the construction and application of AIE-active molecules, which thus inspiring young researchers to explore new ideas, innovations, and develop the field of supramolecular chemistry in years to come.

scholarly journals BODIPY- and Porphyrin-Based Sensors for Recognition of Amino Acids and Their Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4523 ◽  
Author(s):  
Marco Farinone ◽  
Karolina Urbańska ◽  
Miłosz Pawlicki
Keyword(s):  
Amino Acids ◽  
Molecular Recognition ◽  
Biological Systems ◽  
Direct Interaction ◽  
Covalent Bonding ◽  
Molecular Probes ◽  
Chiral Discrimination ◽  
Living Matter ◽  
Diverse Range ◽  
Widespread Occurrence

Molecular recognition is a specific non-covalent and frequently reversible interaction between two or more systems based on synthetically predefined character of the receptor. This phenomenon has been extensively studied over past few decades, being of particular interest to researchers due to its widespread occurrence in biological systems. In fact, a straightforward inspiration by biological systems present in living matter and based on, e.g., hydrogen bonding is easily noticeable in construction of molecular probes. A separate aspect also incorporated into the molecular recognition relies on the direct interaction between host and guest with a covalent bonding. To date, various artificial systems exhibiting molecular recognition and based on both types of interactions have been reported. Owing to their rich optoelectronic properties, chromophores constitute a broad and powerful class of receptors for a diverse range of substrates. This review focuses on BODIPY and porphyrin chromophores as probes for molecular recognition and chiral discrimination of amino acids and their derivatives.

USE OF ARTIFICIAL CELLS AS DRUG CARRIERS

2021 ◽  
Author(s):  
Sibel Emir Diltemiz ◽  
Maryam Tavafoghi ◽  
Natan Roberto Barros ◽  
Masamitsu Kanada ◽  
Jyrki Heinamaki ◽  
...  
Keyword(s):  
Biological Systems ◽  
Drug Carriers ◽  
Therapeutic Strategies ◽  
Artificial Cells ◽  
Size Function ◽  
Recent Advances ◽  
Functional Units ◽  
P Cells

Cells are the fundamental functional units of biological systems and mimicking their size, function and complexity is a primary goal in the development of new therapeutic strategies. Recent advances in...

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