A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H+

2021 ◽  
Author(s):  
Zun-Pan She ◽  
Wen-Xin Wang ◽  
Guo-Jiang Mao ◽  
Wen-Li Jiang ◽  
Zhi-Qing Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Sequential Detection ◽  
Normal Cells

A near-infrared fluorescent probe, CyAc, is synthesized for accurately diagnosing cancer in vivo by sequential detection of Cys and H+. CyAc can not only discriminate normal cells and cancer cells, but also distinguish normal mice from tumor mice.

A near-infrared biothiol-specific fluorescent probe for cancer cell recognition

The Analyst ◽  
2019 ◽  
Vol 144 (16) ◽  
pp. 4750-4756 ◽  
Author(s):  
Li Liu ◽  
Rui-Jie Lv ◽  
Jong-Kai Leung ◽  
Qian Zou ◽  
Yue Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cancer Cell ◽  
Cancer Diagnosis ◽  
Near Infrared ◽  
Great Promise ◽  
Cell Recognition ◽  
Normal Cells

A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis.

Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

2017 ◽  
Vol 53 (35) ◽  
pp. 4857-4860 ◽  
Author(s):  
Jiangli Fan ◽  
Shigang Guo ◽  
Suzhen Wang ◽  
Yao Kang ◽  
Qichao Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Enzyme Targeting

NB-AX, the first NIR KIAA1363-targeting fluorescent probe, could be used for the ultrafast lighting up of breast cancer cells and detection of tissues and tumors in vivo.

scholarly journals Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryoichi Katsube ◽  
Kazuhiro Noma ◽  
Toshiaki Ohara ◽  
Noriyuki Nishiwaki ◽  
Teruki Kobayashi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Near Infrared ◽  
Fibroblast Activation Protein ◽  
Therapeutic Resistance ◽  
Fibroblast Activation ◽  
Human Esophageal Cancer

AbstractCancer-associated fibroblasts (CAFs) have an important role in the tumor microenvironment. CAFs have the multifunctionality which strongly support cancer progression and the acquisition of therapeutic resistance by cancer cells. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer treatment that uses a highly selective monoclonal antibody (mAb)-photosensitizer conjugate. We developed fibroblast activation protein (FAP)-targeted NIR-PIT, in which IR700 was conjugated to a FAP-specific antibody to target CAFs (CAFs-targeted NIR-PIT: CAFs-PIT). Thus, we hypothesized that the control of CAFs could overcome the resistance to conventional chemotherapy in esophageal cancer (EC). In this study, we evaluated whether EC cell acquisition of stronger malignant characteristics and refractoriness to chemoradiotherapy are mediated by CAFs. Next, we assessed whether the resistance could be rescued by eliminating CAF stimulation by CAFs-PIT in vitro and in vivo. Cancer cells acquired chemoradiotherapy resistance via CAF stimulation in vitro and 5-fluorouracil (FU) resistance in CAF-coinoculated tumor models in vivo. CAF stimulation promoted the migration/invasion of cancer cells and a stem-like phenotype in vitro, which were rescued by elimination of CAF stimulation. CAFs-PIT had a highly selective effect on CAFs in vitro. Finally, CAF elimination by CAFs-PIT in vivo demonstrated that the combination of 5-FU and NIR-PIT succeeded in producing 70.9% tumor reduction, while 5-FU alone achieved only 13.3% reduction, suggesting the recovery of 5-FU sensitivity in CAF-rich tumors. In conclusion, CAFs-PIT could overcome therapeutic resistance via CAF elimination. The combined use of novel targeted CAFs-PIT with conventional anticancer treatments can be expected to provide a more effective and sensible treatment strategy.

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85957-85963 ◽  
Author(s):  
Peng Wang ◽  
Ke Wang ◽  
Dan Chen ◽  
Yibo Mao ◽  
Yueqing Gu
Keyword(s):  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Near Infrared

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2.

A near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo

2013 ◽  
Vol 4 (3) ◽  
pp. 1079 ◽  
Author(s):  
Kehua Xu ◽  
Mingming Qiang ◽  
Wen Gao ◽  
Ruixian Su ◽  
Na Li ◽  
...  
Keyword(s):  
Real Time ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Redox Status ◽  
Real Time Imaging

scholarly journals <italic>In vivo</italic> imaging of penicillin G acylase in mice via a near-infrared fluorescent probe

2017 ◽  
Vol 47 (8) ◽  
pp. 994-999
Author(s):  
Xiaohua Li ◽  
Xinyuan He ◽  
Wen Shi ◽  
Haolin Zhang ◽  
Huimin Ma
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Penicillin G Acylase ◽  
Penicillin G

A hypoxia-activated near infrared fluorescent probe for cyclooxygenase-2 and in vivo imaging for tumor and inflammation

2018 ◽  
Vol 265 ◽  
pp. 582-590 ◽  
Author(s):  
Yuezheng Ti ◽  
Ling Yu ◽  
Yao Tang ◽  
Tongxia Jin ◽  
Ming Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cyclooxygenase 2
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