Diastereodivergent synthesis of 4-oxocyclohexanecarbaldehydes by using the modularly designed organocatalysts upon switching on their iminium catalysis

2021 ◽  
Author(s):  
Pranjal Bora ◽  
Satish Jakkampudi ◽  
Ramarao Parella ◽  
Nagaraju Sakkani ◽  
Qipu Dai ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Michael Reaction ◽  
Unsaturated Aldehydes ◽  
Mannich Condensation

The inhibited iminium catalysis of the MDOs was switched on by using trans-cinnamic acid and the activated MDOs were used for catalyzing the domino Mannich condensation/Michael/Michael reaction between ketones and α,β-unsaturated aldehydes.

scholarly journals Development of a general, enantioselective organocatalytic Mukaiyama–Michael reaction with α,β-unsaturated aldehydes

Tetrahedron ◽  
2009 ◽  
Vol 65 (33) ◽  
pp. 6746-6753 ◽  
Author(s):  
Christopher J. Borths ◽  
Diane E. Carrera ◽  
David W.C. MacMillan
Keyword(s):  
Michael Reaction ◽  
Unsaturated Aldehydes

Organocatalytic Enantioselective Aza-Michael Reaction of Nitrogen Heterocycles and α,β-Unsaturated Aldehydes.

ChemInform ◽  
2007 ◽  
Vol 38 (43) ◽  
Author(s):  
Uxue Uria ◽  
Jose L. Vicario ◽  
Dolores Badia ◽  
Luisa Carrillo
Keyword(s):  
Michael Reaction ◽  
Nitrogen Heterocycles ◽  
Unsaturated Aldehydes

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

2016 ◽  
Vol 14 (16) ◽  
pp. 3926-3933 ◽  
Author(s):  
Shanchao Wu ◽  
Yu Li ◽  
Yongqiang Zhang ◽  
Kun Fang ◽  
Guoqiang Dong ◽  
...  
Keyword(s):  
Secondary Amine ◽  
Michael Addition ◽  
Michael Reaction ◽  
Catalytic Amount ◽  
Unsaturated Aldehydes ◽  
The Michael Reaction

The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented.

ChemInform Abstract: Enantioselective Organocatalytic Phospha-Michael Reaction of α,β-Unsaturated Aldehydes.

ChemInform ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. no-no
Author(s):  
Xiaoyan Luo ◽  
Zhiqiang Zhou ◽  
Xin Li ◽  
Xinmiao Liang ◽  
Jinxing Ye
Keyword(s):  
Michael Reaction ◽  
Unsaturated Aldehydes

scholarly journals Synthesis and Antioxidant Activity of Some Novel a Zino and Pyranopyrazole Derivative

2020 ◽  
Author(s):  
Eman O. Hamed ◽  
Nourhan Kh. R. Elhoseni ◽  
Mohamed G. Assy ◽  
Wesam Shehab ◽  
Magda H. Abdellattif
Keyword(s):  
Antioxidant Activity ◽  
Cinnamic Acid ◽  
Michael Reaction ◽  
Vital Role ◽  
Moderate Activity ◽  
Unsaturated Ketone ◽  
Pathogenic Microorganisms ◽  
Benzoyl Isothiocyanate ◽  
Acetate Mixture ◽  
Pyran Derivative

Abstract Background: Pyranopyrazole derivatives has vital role in the class of organic compounds because of their broad spectrum of biological as well as pharmacological importance.Results: Our current goal is the [3+3] Cycloaddition of benzoyl isothiocyanate and pyrazolone 1 undergo oxidation cyclization producing pyrazoloxadiazine 3. The diol 5 was obtained as a condensation of two equivalent of 1 with thiopene-2-carboxaldhyde in acetic acid above sodium acetate mixture. When the condensation carried out in presence of piperidine under fusion the unsaturated ketone 4 was obtained. The cyclocondensation of pyrazolone 1 and pyruvic acid derivative in the presence of aminotive reagent resulted in pyrazolo pyrimidine 7. The pyrazolo pyran derivative 11 was resulted from the [3+3] cycloaddition of 1 and cinnamic acid. ᴽpyrone derivative was prepared by acylation of 12 with to equivalent of acetic anhydride. Phthalic anhydride undergoes arolyation using zinc chloride as a catalyst. The cyclic keto acid 23 was synthesized by the action of succinic anhydride on 12 in acetic medium. Cinnamic acid and 12 leads to pyrazole derivative 24 through Michael reaction. All of the tested compounds showed good microbial activity against pathogenic microorganisms. Newly synthesized compounds were screened for their antioxidant activity. Some of tested compounds exhibited promising activities.Conclusions: The newly synthesized compounds were found to be potent towards antioxidant activity. Moreover, the results showed that nearly a compound 5 was found to be the most potent levels of activity. Additionally, compounds 13, 14, 16, 22, 23 and 24 were found to have moderate activity. While compound 14 was found the lowest potent levels.

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