Photothermal Therapy may be a Double-edge Sword by Inducing the Formation of Bacterial Antibiotic Tolerance

2022 ◽  
Author(s):  
Yun Qiu ◽  
Shimin Yu ◽  
Yulan Wang ◽  
Leyi Xiao ◽  
Linsen Pei ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Cell Membrane ◽  
Photothermal Therapy ◽  
Antibiotic Tolerance ◽  
Double Edge ◽  
Double Edge Sword ◽  
Activity State ◽  
Low Activity

Photothermal nanoparticles are thought to be the most potential candidates against infectious disease, by disrupting cell membrane and inhibiting metabolism. However, subpopulation survived with this low-activity state may be endowed...

scholarly journals HDAC inhibitors: Double edge sword for TRAIL cancer therapy?

2005 ◽  
Vol 4 (10) ◽  
pp. 1113-1115 ◽  
Author(s):  
Simone Fulda ◽  
Klaus-Michael Debatin
Keyword(s):  
Cancer Therapy ◽  
Hdac Inhibitors ◽  
Double Edge ◽  
Double Edge Sword

WITHDRAWN: Dendritic cells: A double-edge sword in atherosclerotic inflammation

2013 ◽  
Author(s):  
Dimitry A. Chistiakov ◽  
Igor A. Sobenin ◽  
Alexander N. Orekhov ◽  
Yuri V. Bobryshev
Keyword(s):  
Dendritic Cells ◽  
Double Edge ◽  
Double Edge Sword

Protected Areas as a Double Edge Sword: An Analysis of Factors Driving Urbanization in Their Surroundings

2021 ◽  
Author(s):  
Alberto Gonzalez Garcia ◽  
Ignacio Palomo ◽  
Manuel Arboledas ◽  
José A. González ◽  
Marta Múgica ◽  
...  
Keyword(s):  
Protected Areas ◽  
Double Edge ◽  
Double Edge Sword

scholarly journals Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Shuping Zhang ◽  
Wei Xin ◽  
Gregory J. Anderson ◽  
Ruibin Li ◽  
Ling Gao ◽  
...  
Keyword(s):  
Fenton Reaction ◽  
Energy Production ◽  
Iron Homeostasis ◽  
Regulated Cell Death ◽  
Double Edge ◽  
Double Edge Sword ◽  
Novel Interactions ◽  
Metabolic Activities ◽  
Species Production

AbstractIron is vital for many physiological functions, including energy production, and dysregulated iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized form of regulated cell death that is characterized by iron dependency and lipid peroxidation, and this process has been reported to be involved in multiple diseases. The mechanisms underlying ferroptosis are complex, and involve both well-described pathways (including the iron-induced Fenton reaction, impaired antioxidant capacity, and mitochondrial dysfunction) and novel interactions linked to cellular energy production. In this review, we examine the contribution of iron to diverse metabolic activities and their relationship to ferroptosis. There is an emphasis on the role of iron in driving energy production and its link to ferroptosis under both physiological and pathological conditions. In conclusion, excess reactive oxygen species production driven by disordered iron metabolism, which induces Fenton reaction and/or impairs mitochondrial function and energy metabolism, is a key inducer of ferroptosis.

Advances in cell membrane-camouflaged nano-carrier for photothermal therapy

2018 ◽  
Vol 11 (3) ◽  
pp. 392-400
Author(s):  
昝明辉 ZAN Ming-hui ◽  
饶 浪 RAO Lang ◽  
谢 伟 XIE Wei ◽  
朱道明 ZHU Dao-ming ◽  
郄兴旺 QIE Xing-wang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Photothermal Therapy
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