Bismuth telluride functionalized bismuth oxychloride used for enhanced antibacterial and would healing efficacy with sunlight irradiation

2021 ◽  
Author(s):  
Rui Chen ◽  
Liqi Wei ◽  
Yan Yan ◽  
Guoli Chen ◽  
Xiaodong Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bismuth Telluride ◽  
Tissue Damage ◽  
Healing Process ◽  
Wound Healing Process ◽  
Sunlight Irradiation ◽  
Bacteria Inactivation ◽  
Semiconductor Nanomaterials ◽  
Healing Wounds ◽  
Would Healing

Bacterial infection can lead to chronic non-healing wounds and serious tissue damage. Wound healing process could be accelerated through bacteria inactivation by some semiconductor nanomaterials with the irradiation of light....

scholarly journals Novel formulation approaches for wound healing

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 937-948
Author(s):  
Tanaji D Nandgude ◽  
Syed Nateque Naser
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Wound Management ◽  
Wound Healing Process ◽  
Anatomic Structure ◽  
Tissue Integrity ◽  
Molecular Events ◽  
Acute Injuries ◽  
Healing Wounds

A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target various parts of the wound healing process depends on numerous types of wounds and novel polymers utilised for the conveyance of medications to both acute and ceaseless injuries. These include alginate, hydrocolloids, hydrofibers, polyurethane, and hydrogels. This article gives particular importance to different novel approaches in the management of wound healing. This review draws out the data and hopes to provide understanding into traditional, current and imminent techniques and methods for wound management.

scholarly journals Bicellular Tight Junctions and Wound Healing

2018 ◽  
Vol 19 (12) ◽  
pp. 3862 ◽  
Author(s):  
Junhe Shi ◽  
May Barakat ◽  
Dandan Chen ◽  
Lin Chen
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Epithelial Cells ◽  
Tight Junctions ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Healing Process ◽  
Intercellular Junctions ◽  
Wound Healing Process ◽  
Healing Wounds

Bicellular tight junctions (TJs) are intercellular junctions comprised of a variety of transmembrane proteins including occludin, claudins, and junctional adhesion molecules (JAMs) as well as intracellular scaffold proteins such as zonula occludens (ZOs). TJs are functional, intercellular structures that form a barrier between adjacent cells, which constantly seals and unseals to control the paracellular passage of molecules. They are primarily present in the epithelial and endothelial cells of all tissues and organs. In addition to their well-recognized roles in maintaining cell polarity and barrier functions, TJs are important regulators of signal transduction, which modulates cell proliferation, migration, and differentiation, as well as some components of the immune response and homeostasis. A vast breadth of research data is available on TJs, but little has been done to decipher their specific roles in wound healing, despite their primary distribution in epithelial and endothelial cells, which are essential contributors to the wound healing process. Some data exists to indicate that a better understanding of the functions and significance of TJs in healing wounds may prove crucial for future improvements in wound healing research and therapy. Specifically, recent studies demonstrate that occludin and claudin-1, which are two TJ component proteins, are present in migrating epithelial cells at the wound edge but are absent in chronic wounds. This indicates that functional TJs may be critical for effective wound healing. A tremendous amount of work is needed to investigate their roles in barrier function, re-epithelialization, angiogenesis, scar formation, and in the interactions between epithelial cells, endothelial cells, and immune cells both in the acute wound healing process and in non-healing wounds. A more thorough understanding of TJs in wound healing may shed new light on potential research targets and reveal novel strategies to enhance tissue regeneration and improve wound repair.

scholarly journals The Role of Chemokines in Wound Healing

2018 ◽  
Vol 19 (10) ◽  
pp. 3217 ◽  
Author(s):  
Anisyah Ridiandries ◽  
Joanne Tan ◽  
Christina Bursill
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Healing Process ◽  
Inflammatory Cells ◽  
Wound Healing Process ◽  
Preclinical Research ◽  
Cxcr4 Antagonist ◽  
Impaired Wound Healing ◽  
Novel Approach ◽  
Healing Wounds

Wound healing is a multistep process with four overlapping but distinct stages: hemostasis, inflammation, proliferation, and remodeling. An alteration at any stage may lead to the development of chronic non-healing wounds or excessive scar formation. Impaired wound healing presents a significant health and economic burden to millions of individuals worldwide, with diabetes mellitus and aging being major risk factors. Ongoing understanding of the mechanisms that underly wound healing is required for the development of new and improved therapies that increase repair. Chemokines are key regulators of the wound healing process. They are involved in the promotion and inhibition of angiogenesis and the recruitment of inflammatory cells, which release growth factors and cytokines to facilitate the wound healing process. Preclinical research studies in mice show that the administration of CCL2, CCL21, CXCL12, and a CXCR4 antagonist as well as broad-spectrum inhibition of the CC-chemokine class improve the wound healing process. The focus of this review is to highlight the contributions of chemokines during each stage of wound healing and to discuss the related molecular pathologies in complex and chronic non-healing wounds. We explore the therapeutic potential of targeting chemokines as a novel approach to overcome the debilitating effects of impaired wound healing.

scholarly journals Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Pawel Olczyk ◽  
Katarzyna Komosinska-Vassev ◽  
Grzegorz Wisowski ◽  
Lukasz Mencner ◽  
Jerzy Stojko ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Wound Healing Process ◽  
Burn Wound ◽  
Burn Treatment ◽  
Burn Wound Healing ◽  
Fibronectin Expression ◽  
The Matrix ◽  
Healing Wounds

The aim of the study was to assess the propolis effect on fibronectin metabolism in the course of burn wounds healing process. A model of burn wound healing of pig skin was applied. The amount of the released glycoprotein was assessed by a surface plasmon resonance. The profile of extracted fibronectin components was also assessed by an electrophoresis in polyacrylamide gel, with a subsequent immunodetection by Western Blotting. Propolis burn treatment decreased the release of fibronectin components from healing wounds in relation to damages treated with silver sulfadiazine. The main reason of decreased extraction of fibronectin components from wounds treated with propolis was a substantial decrease of degradation product release of the mentioned glycoprotein, which was observed particularly from the 3rd to 5th day of the repair. Wounds treatment with propolis demonstrated, especially in relation to damages treated with silver sulfadiazine, the decreased release of synthesized fibronectin molecules. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process. The influence of propolis is reflected in prevention of fibronectin biosynthesis as well as its degradation in the wound area. The above-mentioned metabolic changes may decrease the risk of complications in the repair wounds process.

Efficient in vivo wound healing using noble metal nanoclusters

Nanoscale ◽  
2021 ◽  
Author(s):  
Kuo Li ◽  
Dan Li ◽  
Cheng-Hsuan Li ◽  
pengfei Zhuang ◽  
Chunmei Dai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Noble Metal ◽  
Healing Process ◽  
Tissue Remodeling ◽  
Wound Healing Process ◽  
Metal Nanoclusters ◽  
Healing Wounds ◽  
Noble Metal Nanoclusters

The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not...

scholarly journals Diabetic Wound Care: A Concise Review of Diabetic Wound and Skincare Ingredients

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Mohammad Afsahi ◽  
Hamid Reza Ahmadi Ashtiani ◽  
Amir Hosein Askari Pour ◽  
Ebrahim Hazrati
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Topical Administration ◽  
The Body ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
Normal Wound Healing ◽  
Healing Wounds ◽  
Diabetic Wounds

: Chronic wound healing remains a complicated issue in the world's scientific health society. Alterations in the human body conditions such as biochemical, immunological, and physiological states may lead to non-healing wounds, making the treatment an insurmountably long and expensive procedure. Diabetes mellitus disposes the body to many complicated conditions while preventing diabetic wounds away from the normal wound-healing process. As topical administration is a favorable route of treating wounds, here, in this article, different topical materials and their roles are briefly reviewed.

scholarly journals Ekek anti mikroba terapi larva

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Healing Process ◽  
Wound Management ◽  
Wound Healing Process ◽  
Healing Wounds ◽  
Chronic Wound Management ◽  
Very High ◽  
Anti Inflammation ◽  
Larval Therapy

Abstract: Chronic wound is still a world-wide problem that spends a very high cost related to its management and treatment. Although there are a lot of promising studies about wound healing process, the prevalence and incidence of chronic wound and its complications are still high. Conventionally, the management of chronic wound consists of surgical debridement, manual irrigation, dressing, and antimicrobial therapy (topical and/or systemic). It is accepted that microbial biofilm and its complexity play important roles in non-healing wounds. This biofilm consists of polymicrobial colonies embedded in exopolymeric matrix produced by the biofilm itself and has a high tolerance to host defence mechanisme, antibiotics, and antiseptics. Larval therapy has been approved by FDA to be used in chronic wound management. It has antimicrobial effects besides its other effects on wound healing inter alia mechanical debridement, anti-inflammation, angiogenesis, and destabilization of biofilm enzymes. Further studies are needed to explore the effects of larval therapy, especially its excretion/secretion components, so that it can be applicated more aesthetically.Keywords: chronic wound, wound healing process, biofilm, larval therapyAbstrak: Luka kronis merupakan masalah kesehatan di seluruh dunia yang telah memboroskan biaya cukup tinggi. Walaupun telah terjadi kemajuan dan pemahaman mengenai penyembuhan luka, prevalensi dan insidensi luka kronis dan komplikasinya tetap meningkat pesat. Secara konvensional, perawatan luka kronis terdiri dari debrideman, irigasi manual, dressing untuk mempertahankan kelembaban, dan terapi antimikroba (topikal dan atau sistemik). Adanya biofilm mikroba serta kompleksitasnya pada luka kronis telah disepakati sebagai salah satu kunci gagalnya penyembuhan luka. Biofilm mikroba terdiri dari koloni-koloni mikroorganisme polimikrobial terkemas dalam matriks eksopolimerik yang diproduksi olehnya sendiri dan memiliki toleransi tinggi terhadap pertahanan pejamu (host), antibiotik, dan antiseptik. Terapi larva telah diterima oleh FDA dan telah terbukti berefek antimikroba disamping efek lainnya terhadap penyembuhan luka, antara lain: debrideman mekanis, anti-inflamasi, angiogenesis, dan destabilisasi enzim biofilm pada luka. Studi lanjut diperlukan untuk mengeksplorasi efek terapi larva terutama komponen ekskresi/skresi larva terhadap penyembuhan luka agar dapat diaplikasikan secara lebih estetik.Kata kunci: luka kronis, penyembuhan luka, biofilm, terapi larva

scholarly journals Angiogenin and Copper Crossing in Wound Healing

2021 ◽  
Vol 22 (19) ◽  
pp. 10704
Author(s):  
Lorena Maria Cucci ◽  
Cristina Satriano ◽  
Tiziano Marzo ◽  
Diego La Mendola
Keyword(s):  
Wound Healing ◽  
Blood Vessel ◽  
Healing Process ◽  
New Drugs ◽  
Angiogenic Factor ◽  
Wound Healing Process ◽  
Chemical Signaling ◽  
Transport Pathways ◽  
Relevant Role ◽  
Healing Wounds

Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.

scholarly journals Peranan Stres Oksidatif pada Proses Penyembuhan Luka

2018 ◽  
Vol 5 (2) ◽  
pp. 22
Author(s):  
Handy Arief ◽  
M Aris Widodo
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Free Radical ◽  
Tissue Damage ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Wound Healing Process ◽  
Oxygen Species

Wound healing is a complex dynamic process characterized by a series of events that occur in almost all type of tissue damage. In the early phase of the inflammatory response, neutrophils and macrophages enters into the injured tissue and the cells produce reactive oxygen species that can give a beneficial or detrimental effects. Oxidative stress is a condition occurs that shows imbalance between prooxidant or free radical and antioxidant that have a function to maintain the condition of the tissue damage that occurs. So Oxidative stress occurs when the production of Reactive Oxygen Species occurring is higher than the antioxidants existing as an intrinsic defense. Reactive Oxygen Species and Reactive Nitrogen Species are important components in the healing process of wounds and is necessary to be in the state of homeostasis to prevent oksidatif stress. The major components of ROS are superoxide (O2•), hydroxyl radical (OH•) and hydrogen peroxide (H2O2), which includes RNS are nitric oxide (NO•), nitrous oxide (NO2•), nitroxyl anion (HNO) and peroxynitrite (ONOO-) which could be form by the reaction between superoxide and nitric oxide. The existence of excessive O2 amount in the wound and the presence of excess NO can increase the incidence of oxidative stress that interfere with wound healing process. Oxidative stress plays a role in the inflammatory phase, proliferation and remodeling phase by increasing angiogenesis and affect other cells including endothelial cells in secreting NO. So the strategy in controlling oxidative stress is by increasing antioxidant level which is a scavenger to free radical excessive superoxide formation so preventing interference with the wound healing process. 

scholarly journals Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Mariena JA van der Plas ◽  
Jun Cai ◽  
Jitka Petrlova ◽  
Karim Saleh ◽  
Sven Kjellström ◽  
...  
Keyword(s):  
Wound Healing ◽  
Method Development ◽  
Healing Process ◽  
Wound Healing Process ◽  
Proof Of Concept ◽  
Normal Wound Healing ◽  
Promising Tool ◽  
Healing Wounds ◽  
High Degree ◽  
First Time

The normal wound healing process is characterised by proteolytic events, whereas infection results in dysfunctional activations by endogenous and bacterial proteases. Peptides, downstream reporters of these proteolytic actions, could therefore serve as a promising tool for diagnosis of wounds. Using mass-spectrometry analyses, we here for the first time characterise the peptidome of human wound fluids. Sterile post-surgical wound fluids were found to contain a high degree of peptides in comparison to human plasma. Analyses of the peptidome from uninfected healing wounds and Staphylococcus aureus -infected wounds identify unique peptide patterns of various proteins, including coagulation and complement factors, proteases, and antiproteinases. Together, the work defines a workflow for analysis of peptides derived from wound fluids and demonstrates a proof-of-concept that such fluids can be used for analysis of qualitative differences of peptide patterns from larger patient cohorts, providing potential biomarkers for wound healing and infection.

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