Nanoparticle-based colorimetric sensors to detect neurodegenerative disease biomarkers

2021 ◽  
Author(s):  
Qingqing Fan ◽  
Yuan Gao ◽  
Federico Mazur ◽  
Rona Chandrawati
Keyword(s):  
Neurodegenerative Disease ◽  
Neurodegenerative Disorders ◽  
Health Conditions ◽  
Brain Cells ◽  
Current Sensing ◽  
Brain Mass ◽  
Disease Biomarkers ◽  
Impaired Function ◽  
Colorimetric Sensors

Neurodegenerative disorders (NDDs) are progressive, incurable health conditions that primarily affect brain cells, and result in loss of brain mass and impaired function. Current sensing technologies for NDD detection are...

Immunotherapy for Neurodegenerative Disorders

2016 ◽  
Author(s):  
David Morgan
Keyword(s):  
At Risk ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Neurodegenerative Disorders ◽  
Health Concern ◽  
Cultured Neurons ◽  
Preclinical Data ◽  
Age Related ◽  
The World ◽  
Disease Modifying

Neurodegenerative diseases are a growing health concern through the world as gains in longevity result in an increased population at risk of these age-related disorders. Unfortunately no disease modifying treatments exist for these disorders. Over the last three decades enormous insights have been gained into the causes of these disorders. One approach to treating these diseases is to direct immunotherapy against the misfolded proteins that accumulate within the brains of those with neurodegenerative disease in an attempt to clear the accumulating proteins and slow or prevent expression of the disease. This chapter summarizes the recent (and frustrating) experience with anti-Aβ‎ immunotherapy to treat mild to moderate Alzheimer’s disease, and holds hope that newer generation antibodies and treating presymptomatic disease will have greater impact. In addition, it reviews the preclinical data regarding approaches to treating tau, synuclein, and prion disorders, all of which demonstrate consistent effects in mice and cultured neurons.

scholarly journals Molecular mechanisms of proteinopathies across neurodegenerative disease: a review

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Alexander P. Marsh
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Neurodegenerative Disorders ◽  
Protein Misfolding ◽  
Molecular Mechanisms ◽  
Current Data ◽  
Main Body ◽  
Molecular Events ◽  
Underlying Pathology

Abstract Background Although there is a range of different symptoms across neurodegenerative diseases, they have been noted to have common pathogenic features. An archetypal feature shared between these diseases is protein misfolding; however, the mechanism behind the proteins abnormalities is still under investigation. There is an emerging hypothesis in the literature that the mechanisms that lead to protein misfolding may be shared across neurodegenerative processes, suggesting a common underlying pathology. Main body This review discusses the literature to date of the shared features of protein misfolding, failures in proteostasis, and potential propagation pathways across the main neurodegenerative disorders. Conclusion The current data suggests, despite overarching processes being shared, that the molecular events implicated in protein pathology are distinct across common neurodegenerative disorders.

scholarly journals Challenges and Opportunities of Targeting Astrocytes to Halt Neurodegenerative Disorders

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2019
Author(s):  
Chiara F. Valori ◽  
Agostino Possenti ◽  
Liliana Brambilla ◽  
Daniela Rossi
Keyword(s):  
Glial Cells ◽  
Neurodegenerative Disorders ◽  
Lifestyle Changes ◽  
Health Conditions ◽  
Current Debate ◽  
Environmental Cues ◽  
Western Population ◽  
Pathological Conditions ◽  
Challenges And Opportunities ◽  
The Central Nervous System

Neurodegenerative diseases are a heterogeneous group of disorders whose incidence is likely to duplicate in the next 30 years along with the progressive aging of the western population. Non-cell-specific therapeutics or therapeutics designed to tackle aberrant pathways within neurons failed to slow down or halt neurodegeneration. Yet, in the last few years, our knowledge of the importance of glial cells to maintain the central nervous system homeostasis in health conditions has increased exponentially, along with our awareness of their fundamental and multifaced role in pathological conditions. Among glial cells, astrocytes emerge as promising therapeutic targets in various neurodegenerative disorders. In this review, we present the latest evidence showing the astonishing level of specialization that astrocytes display to fulfill the demands of their neuronal partners as well as their plasticity upon injury. Then, we discuss the controversies that fuel the current debate on these cells. We tackle evidence of a potential beneficial effect of cell therapy, achieved by transplanting astrocytes or their precursors. Afterwards, we introduce the different strategies proposed to modulate astrocyte functions in neurodegeneration, ranging from lifestyle changes to environmental cues. Finally, we discuss the challenges and the recent advancements to develop astrocyte-specific delivery systems.

scholarly journals Lead, Manganese, and Methylmercury as Risk Factors for Neurobehavioral Impairment in Advanced Age

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Bernard Weiss
Keyword(s):  
Risk Factors ◽  
Adverse Effects ◽  
Neurodegenerative Disease ◽  
Early Development ◽  
Neurodegenerative Disorders ◽  
Advanced Age ◽  
Metal Contaminants ◽  
Aging Populations ◽  
The Brain

Contamination of the environment by metals is recognized as a threat to health. One of their targets is the brain, and the adverse functional effects they induce are reflected by neurobehavioral assessments. Lead, manganese, and methylmercury are the metal contaminants linked most comprehensively to such disorders. Because many of these adverse effects can appear later in life, clues to the role of metals as risk factors for neurodegenerative disorders should be sought in the exposure histories of aging populations. A review of the available literature offers evidence that all three metals can produce, in advanced age, manifestations of neurobehavioral dysfunction associated with neurodegenerative disease. Among the critical unresolved questions is timing; that is, during which periods of the lifespan, including early development, do environmental exposures lay the foundations for their ultimate effects?

scholarly journals Role of PPARγin the Differentiation and Function of Neurons

PPAR Research ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Rodrigo A. Quintanilla ◽  
Elias Utreras ◽  
Fabián A. Cabezas-Opazo
Keyword(s):  
Neuropathic Pain ◽  
Neurodegenerative Disorders ◽  
Neuronal Death ◽  
Neuronal Development ◽  
Brain Cells ◽  
Neuronal Processes ◽  
And Function ◽  
Pain Regulation ◽  
Important Evidence

Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases. Recent evidence has showed that the activation of PPARγpathway promoted neuronal differentiation and axon polarity. In addition, activation of PPARγusing thiazolidinediones (TZDs) prevented neurodegeneration by reducing neuronal death, improving mitochondrial function, and decreasing neuroinflammation in neuropathic pain. In this review, we will discuss important evidence that supports a possible role of PPARγin neuronal development, improvement of neuronal health, and pain signaling. Therefore, activation of PPARγis a potential target with therapeutic applications against neurodegenerative disorders, brain injury, and pain regulation.

Point-of-Care Devices Using Disease Biomarkers To Diagnose Neurodegenerative Disorders

2018 ◽  
Vol 36 (3) ◽  
pp. 290-303 ◽  
Author(s):  
Ting-Yen Wei ◽  
Yun Fu ◽  
Kuo-Hsuan Chang ◽  
Kun-Ju Lin ◽  
Yu-Jen Lu ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Point Of Care ◽  
Disease Biomarkers
Sign in / Sign up

Export Citation Format

Share Document