Superhydrophilic Multifunctional Nanotextured Titanium Dental Implants: In Vivo Short and Long-term Response in a Porcine Model

2021 ◽  
Author(s):  
Anil Mathew ◽  
Silpa Abraham ◽  
Shamilin Stephen ◽  
Anna Serene Babu ◽  
Siddaramana Gowd ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Dental Implants ◽  
Porcine Model ◽  
Multifunctional Device ◽  
Short And Long Term ◽  
Pathogenic Agents ◽  
Titanium Dental Implants ◽  
Term Response

Current clinical demand in dental implantology is for a multifunctional device with optimum mechanical properties, improved biocompatibility, and bioactivity, and having differential interactions with cells and pathogenic agents. This would...

scholarly journals Short and long term response to argon plasma therapy for hemorrhagic radiation proctitis

2019 ◽  
Vol 111 ◽  
Author(s):  
Elizabeth Montes de Oca Megías ◽  
Maricela Morera Pérez ◽  
Guillermo Noa Pedroso ◽  
Felipe Piñol Jiménez ◽  
Mildred Armenteros Torres
Keyword(s):  
Argon Plasma ◽  
Radiation Proctitis ◽  
Plasma Therapy ◽  
Short And Long Term ◽  
Term Response

Lithium Restores Abnormal Platelet 5-HT Transport in Patients with Affective Disorders

1980 ◽  
Vol 136 (3) ◽  
pp. 235-238 ◽  
Author(s):  
Alec Coppen ◽  
Cynthia Swade ◽  
Keith Wood
Keyword(s):  
Blood Platelets ◽  
Lithium Treatment ◽  
Before And After ◽  
Short And Long Term ◽  
5 Ht Uptake ◽  
Depressive Patients ◽  
Rate Of Accumulation

SummaryKinetic analysis of the transport of 5-HT into the blood platelets of depressed patients and recovered depressive patients has shown that the rate of accumulation of 5-hydroxytryptamine (5-HT) is significantly decreased both before and after recovery from the illness. This abnormality is corrected by both short and long-term lithium treatment. As a corollary to these studies, the effect of lithium in vitro on 5-HT uptake has been studied and the results are opposite to those reported in vivo. These findings suggest that lithium acts indirectly, and possible mechanisms of its action are discussed.

scholarly journals Short- and Long-Term Multilineage Repopulating Hematopoietic Stem Cells in Late Fetal and Newborn Mice: Models for Human Umbilical Cord Blood

Blood ◽  
1997 ◽  
Vol 90 (1) ◽  
pp. 174-181 ◽  
Author(s):  
David E. Harrison ◽  
Clinton M. Astle
Keyword(s):  
Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Functional Abilities ◽  
Newborn Mice ◽  
Hematopoietic Stem ◽  
Short And Long Term ◽  
Marrow Cells

Abstract Blood from late fetal and newborn mice is similar to umbilical cord blood obtained at birth in human beings, an important source of stem cells for clinical transplantation. The mouse model is useful because long-term functions can be readily assayed in vivo. To evaluate the functions of hematopoietic precursors in the blood and other tissues of late fetal and newborn mice, short- and long-term multilineage repopulating abilities were measured in vivo by competitive repopulation. Manipulations that might affect cell function, such as enrichment, tissue culture, or retroviral marking, were avoided. Hematopoietic stem cell functions of late fetal or newborn blood, liver, and spleen, were assayed as myeloid and lymphoid repopulating abilities relative to standard adult marrow cells. Donor cells from these tissues as well as adult control donor marrow cells were all of the same genotype. Cells from each donor tissue were mixed with portions from a pool of standard adult “competitor” marrow distinguished from the donors by genetic differences in hemoglobin and glucosephosphate isomerase. After 21 to 413 days, percentages of donor type myeloid and lymphoid cells in recipient blood were measured to assay the functional abilities of donor precursors relative to the standard. These relative measures are expressed as repopulating units, where each unit is equivalent to the repopulating ability found in 100,000 standard adult marrow cells. Thus, measures of repopulating units do not compare single cells but overall repopulating abilities of donor cell populations. Relative functional abilities in 1 million nucleated cells from late fetal or newborn blood were several times less than those found in adult marrow, but far more than in normal adult blood, and appeared to include long-term functional primitive hematopoietic stem cells (PHSC) similar to those in marrow. To estimate functional abilities of individual PHSC, variances among large groups of identical recipients were analyzed using both the binomial model and competitive dilution, a new model based on the Poisson distribution. The data best fit the hypothesis that individual PHSC from adult marrow, late fetal blood, or newborn blood each produce similar fractions of the total lymphoid and erythroid cells found in the recipient for many months.

Ex Vivo Expansion of Genetically Marked Rhesus Peripheral Blood Progenitor Cells Results in Diminished Long-Term Repopulating Ability

Blood ◽  
1998 ◽  
Vol 92 (4) ◽  
pp. 1131-1141 ◽  
Author(s):  
J.F. Tisdale ◽  
Y. Hanazono ◽  
S.E. Sellers ◽  
B.A. Agricola ◽  
M.E. Metzger ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Ex Vivo ◽  
Retroviral Vectors ◽  
Ex Vivo Expansion ◽  
Us Government ◽  
Government Work ◽  
Stromal Support ◽  
Short And Long Term

Abstract The possibility of primitive hematopoietic cell ex vivo expansion is of interest for both gene therapy and transplantation applications. The engraftment of autologous rhesus peripheral blood (PB) progenitors expanded 10 to 14 days were tracked in vivo using genetic marking. Stem cell factor (SCF)/granulocyte colony-stimulating factor (G-CSF)–mobilized and CD34-enriched PB cells were divided into two equal aliquots and transduced with one of two retroviral vectors carrying the neomycin-resistance gene (neo) for 4 days in the presence of interleukin-3 (IL-3), IL-6, and SCF in the first 5 animals, IL-3/IL-6/SCF/Flt-3 ligand (FLT) in 2 subsequent animals, or IL-3/IL-6/SCF/FLT plus an autologous stromal monolayer (STR) in the final 2. At the end of transduction period, one aliquot (nonexpanded) from each animal was frozen, whereas the other was expanded under the same conditions but without vector for a total of 14 days before freezing. After total body irradiation, both the nonexpanded and expanded transduced cells were reinfused. Despite 5- to 13-fold higher cell and colony-forming unit (CFU) doses from the expanded fraction of marked cells, there was greater short- and long-term marking from the nonexpanded cells in all animals. In animals receiving cells transduced and expanded in the presence of IL-3/IL-6/SCF/FLT, engraftment by the marked expanded cells was further diminished. This discrepancy was even more pronounced in the animals who received cells transduced and expanded in the presence of FLT and autologous stroma, with no marking detectable from the expanded cells. Despite lack of evidence for expansion of engrafting cells, we found that the addition of FLT and especially STR during the initial brief transduction period increased engraftment with marked cells into a clinically relevant range. Levels of marked progeny cells originating from the nonexpanded aliqouts were significantly higher than that seen in previous 4 animals receiving cells transduced in the presence of IL-3/IL-6/SCF, with levels of 10% to 20% confirmed by Southern blotting from the nonexpanded IL-3/IL-6/SCF/FLT/STR graft compared with 0.01% in the original IL-3/IL-6/SCF cohort. These results suggest that, although expansion of PB progenitors is feasible ex vivo, their contribution towards both short- and long-term engraftment is markedly impaired. However, a brief transduction in the presence of specific cytokines and stromal support allows engraftment with an encouraging number of retrovirally modified cells. This is a US government work. There are no restrictions on its use.

scholarly journals Mesoporous Silicon: Short and Long Term, In Vitro and In Vivo Correlations of Cellular and Tissue Responses to Mesoporous Silicon Nanovectors (Small 9-10/2013)

Small ◽  
2013 ◽  
Vol 9 (9-10) ◽  
pp. 1721-1721
Author(s):  
Jonathan O. Martinez ◽  
Christian Boada ◽  
Iman K. Yazdi ◽  
Michael Evangelopoulos ◽  
Brandon S. Brown ◽  
...  
Keyword(s):  
Mesoporous Silicon ◽  
Tissue Responses ◽  
Short And Long Term

scholarly journals Short- and long-term efficacy of aspirin and clopidogrel for thromboprophylaxis for mechanical heart valves: An in vivo study in swine

2008 ◽  
Vol 136 (4) ◽  
pp. 908-914 ◽  
Author(s):  
Stephen H. McKellar ◽  
Jess L. Thompson ◽  
Raul F. Garcia-Rinaldi ◽  
Ryan J. MacDonald ◽  
Thoralf M. Sundt ◽  
...  
Keyword(s):  
Heart Valves ◽  
Mechanical Heart Valves ◽  
In Vivo Study ◽  
Term Efficacy ◽  
Short And Long Term

Chronic effects of muscle and nerve-directed stretching on tissue mechanics

2020 ◽  
Vol 129 (5) ◽  
pp. 1011-1023 ◽  
Author(s):  
Ricardo J. Andrade ◽  
Sandro R. Freitas ◽  
François Hug ◽  
Guillaume Le Sant ◽  
Lilian Lacourpaille ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Sciatic Nerve ◽  
Peripheral Nerves ◽  
Tissue Mechanics ◽  
Plantar Flexor ◽  
Chronic Effects ◽  
Flexor Muscles ◽  
Plantar Flexor Muscles

This study demonstrates that the mechanical properties of plantar flexor muscles and sciatic nerve can adapt mechanically to long-term stretching programs. Although interventions targeting muscular or nonmuscular structures are both effective at increasing maximal range of motion, the changes in tissue mechanical properties (stiffness) are specific to the structure being preferentially stretched by each program. We provide the first in vivo evidence that stiffness of peripheral nerves adapts to long-term loading stimuli using appropriate nerve-directed stretching.

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