A pH-triggered fluorescence-switchable extracellular vesicle for tracing drug release and improving drug delivery

2021 ◽  
Author(s):  
Shaobing Zhou ◽  
Rui Su ◽  
Xiang Xiong ◽  
Yingping Li ◽  
Xiaoqing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Extracellular Vesicles ◽  
Extracellular Vesicle ◽  
Clinical Applications ◽  
Clinical Translation ◽  
On Demand

Extracellular vesicles have shown great potential in drug delivery for clinical applications. However, some obstacles are still needed to be overcome before their clinical translation, including on demand release of...

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

scholarly journals Magnetic micropump embedded in contact lens for on-demand drug delivery

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Cong Wang ◽  
Jungyul Park
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
External Magnetic Field ◽  
Drug Release ◽  
Contact Lens ◽  
Tear Film ◽  
Check Valve ◽  
Drug Diffusion ◽  
On Demand ◽  
The Magnetic Field

AbstractIn this paper, we report a thin magnetic micropump embedded in contact lens, which is capable of on-demand one-directional drug delivery. The proposed micropump can be actuated by the external magnetic field whenever needed without the need of battery. A micro check valve was integrated with the micropump for one-directional drug delivery from the micropump to the post-lens tear film. With actuation of the external magnetic field, the micro check valve is opened, and on-demand drug release can be realized. On the contrary, without an external magnetic field, the micro check valve is closed, and the undesired drug diffusion can be prevented. Through the control of the strength and the frequency of the magnetic field pulse, on-demand drug release and controlled dose can be realized.

Environment-stimulated nanocarriers enabling multi-active sites for high drug encapsulation as an “on demand” drug release system

2018 ◽  
Vol 6 (15) ◽  
pp. 2258-2273 ◽  
Author(s):  
F. R. Cheng ◽  
T. Su ◽  
J. Cao ◽  
X. L. Luo ◽  
Li Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Active Sites ◽  
Clinical Applications ◽  
Drug Encapsulation ◽  
High Drug ◽  
Release System ◽  
On Demand ◽  
System P ◽  
Drug Release System

Limited active sites in polyesters hinder fabrication of multifunctional biodegradable nanocarriers for successful clinical applications.

Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

2017 ◽  
Vol 53 (62) ◽  
pp. 8755-8758 ◽  
Author(s):  
Song Wang ◽  
Fei Liu ◽  
Xiang-Ling Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
On Demand ◽  
Controllable Release ◽  
Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

scholarly journals S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Changping Wang ◽  
Chongyi Liu ◽  
Qiyao Wei ◽  
Lei Yang ◽  
Peng Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Visible Light ◽  
Cell Fate ◽  
Degradation Kinetics ◽  
Green Light ◽  
Anticancer Drug Delivery ◽  
On Demand ◽  
Facile Fabrication

Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties.

scholarly journals Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2191 ◽  
Author(s):  
Xuan T. T. Dang ◽  
Jayasinghe Migara Kavishka ◽  
Daniel Xin Zhang ◽  
Marco Pirisinu ◽  
Minh T. N. Le
Keyword(s):  
Extracellular Vesicles ◽  
Drug Carriers ◽  
Clinical Applications ◽  
Clinical Translation ◽  
Future Perspective ◽  
Target Specificity ◽  
Intrinsic Properties ◽  
Isolation Methods ◽  
Promising Solution ◽  
Major Factors

Despite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic delivery system with high target specificity upon systemic administration. In this respect, extracellular vesicles (EVs), as natural carriers of bioactive cargo, have emerged as a promising solution and can be further modified to improve their therapeutic efficacy. In this review, we provide an overview of the biogenesis pathways, biochemical features, and isolation methods of EVs with an emphasis on their many intrinsic properties that make them desirable as drug carriers. We then describe in detail the current advances in EV therapeutics, focusing on how EVs can be engineered to achieve improved target specificity, better circulation kinetics, and efficient encapsulation of therapeutic payloads. We also identify the challenges and obstacles ahead for clinical translation and provide an outlook on the future perspective of EV-based therapeutics.

scholarly journals Bioinspired Extracellular Vesicles: Lessons Learned From Nature for Biomedicine and Bioengineering

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2172 ◽  
Author(s):  
Assaf Zinger ◽  
Ava Brozovich ◽  
Anna Pasto ◽  
Manuela Sushnitha ◽  
Jonathan O. Martinez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acids ◽  
Structure Function ◽  
Small Molecules ◽  
Extracellular Vesicles ◽  
Clinical Applications ◽  
Lessons Learned ◽  
Efficient Communication ◽  
Exchange Information ◽  
Cell Carriers

Efficient communication is essential in all layers of the biological chain. Cells exchange information using a variety of signaling moieties, such as small molecules, proteins, and nucleic acids. Cells carefully package these messages into lipid complexes, collectively named extracellular vesicles (EVs). In this work, we discuss the nature of these cell carriers, categorize them by their origin, explore their role in the homeostasis of healthy tissues, and examine how they regulate the pathophysiology of several diseases. This review will also address the limitations of using EVs for clinical applications and discuss novel methods to engineer nanoparticles to mimic the structure, function, and features of EVs. Using lessons learned from nature and understanding how cells use EVs to communicate across distant sites, we can develop a better understanding of how to tailor the fundamental features of drug delivery carriers to encapsulate various cargos and target specific sites for biomedicine and bioengineering.

scholarly journals Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 442 ◽  
Author(s):  
Prakash Gangadaran ◽  
Byeong-Cheol Ahn
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Extracellular Vesicle ◽  
Native Structure ◽  
Advantages And Disadvantages ◽  
Intracellular Communication ◽  
Therapeutic Molecules ◽  
Organ Tropism

Extracellular vesicles (EVs) are small membrane-based nanovesicles naturally released from cells. Extracellular vesicles mimetics (EVMs) are artificial vesicles engineered from cells or in combination with lipid materials, and they mimic certain characteristics of EVs. As such, EVs facilitate intracellular communication by carrying and delivering biological materials, such as proteins, lipids, and nucleic acids, and they have been found to find organ tropism in preclinical studies. Because of their native structure and characteristics, they are considered promising drug carriers for future clinical use. This review outlines the origin and composition of natural EVs and EVM engineering and internalization. It then details different loading approaches, with examples of the drug delivery of therapeutic molecules. In addition, the advantages and disadvantages of loading drugs into EVs or EVMs as a drug delivery system are discussed. Finally, the advantages of EVMs over EVs and the future clinical translation of EVM-based drug delivery platforms are outlined.

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