Hydrophilic hindering and hydrophobic growing: a vesicle glycometabolism multi-drug combination therapeutic against Alzheimer disease

2021 ◽  
Author(s):  
Jian Ren ◽  
Fuxin Jiang ◽  
Shaoteng Wang ◽  
Haodong Hu ◽  
Bo Zhang ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Combination Therapy ◽  
Drug Combination ◽  
Polymer Micelle ◽  
Complex Chemical ◽  
Drug Vehicle ◽  
Synergy Mechanism

The advanced drug vehicle exploitation and the sophisticated synergy mechanism revelation are two great difficulties in the combination therapy. Compared with most readily available polymer micelle, some undiscovered complex chemical...

scholarly journals Drug combination therapy increases successful drug repositioning

2016 ◽  
Vol 21 (7) ◽  
pp. 1189-1195 ◽  
Author(s):  
Wei Sun ◽  
Philip E. Sanderson ◽  
Wei Zheng
Keyword(s):  
Combination Therapy ◽  
Drug Combination ◽  
Drug Repositioning ◽  
Drug Combination Therapy

Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection

Parasitology ◽  
2021 ◽  
pp. 1-29
Author(s):  
Mariana Strauss ◽  
M. Silvina Lo Presti ◽  
Juan C. Ramírez ◽  
P. Carolina Bazán ◽  
Daniela A. Velázquez López ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Trypanosoma Cruzi ◽  
Tissue Distribution ◽  
Mixed Infection ◽  
Drug Combination ◽  
Drug Combination Therapy ◽  
Differential Tissue

scholarly journals A COMPARATIVE EVALUATION OF THE EFFICACY OF TRIPLE DRUG THERAPY WITH DUAL DRUG THERAPY IN COPD PATIENTS

2018 ◽  
Vol 10 (4) ◽  
pp. 105
Author(s):  
Pathan Amanulla Khan ◽  
A. Sujala ◽  
B.b. Sarah Nousheen ◽  
Ayesha Farhath Fatima ◽  
Hibba Tul Ala ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Combination Therapy ◽  
Triple Therapy ◽  
Drug Combination ◽  
Dual Therapy ◽  
Drug Combination Therapy ◽  
Copd Patients ◽  
Number Of Patients ◽  
Dual Drug

Objective: The present study was conducted with the objective of analyzing the efficacy of triple-drug combination therapy (formoterol, ciclesonide, tiotropium) by comparing it with double drug combination therapy (formoterol, budesonide).Methods: A prospective observational study was conducted. Sixty patients were enrolled, and divided into two groups of thirty each; one group was treated with the double-drug and the other with a triple drug combination. FEV1 and FVC pre-and post-treatment in either group were assessed spirometrically. Score ranges of 0-10, 11-20 and 21-30 were allotted to mild, moderate and severe categories and results were analyzed statistically.Results: Of the 60 patients recruited, 61-70 y olds constituted the majority (35%) of the population. Males (63.3%) were more in number compared to females (36.6%). Twenty-three of thirty-eight men smoked (60.5%); there were no female smokers. Common symptoms included cough (93.3%), dyspnoea (85%), fever (45%) and haemoptysis (15%). Hypertension accounted for 70% of patient comorbidities, followed by diabetes (60%) and cardiovascular diseases (40%). Three months after treatment with triple therapy, a significant increase in the differences of means of both FEV1 (14.27) and FVC (14.90) values was observed. Further analysis based on score ranges demonstrated that triple therapy administration markedly reduced the number of patients suffering from severe COPD.Conclusion: Our comparative analysis indicated that triple therapy was more effective in improving lung function, enhancing patients’ quality of life (evidenced from score ranges) thereby reducing mortality. While much is known about the greater effectiveness of triple over dual therapy, researchers to formulate the most effective triple therapy are in progress.

Monitoring unbound warfarin in drug combination therapy by pharmacokinetics and fluorospectrometry

2019 ◽  
Vol 11 (1) ◽  
pp. 92-97
Author(s):  
Jia-ding Guo ◽  
Ying-yue Zhang ◽  
Yan Huo ◽  
Yan-xu Chang ◽  
Er-wei Liu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Drug Combination ◽  
Drug Combination Therapy

Drug combination therapy of systemic lupus erythematosus

1994 ◽  
Vol 16 (2-3) ◽  
Author(s):  
PeterA. Miescher ◽  
Herv� Favre ◽  
Robert Lemoine ◽  
You-Peng Huang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Combination Therapy ◽  
Lupus Erythematosus ◽  
Drug Combination ◽  
Systemic Lupus ◽  
Drug Combination Therapy
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