Manganese Dioxide Nanozyme for Reactive Oxygen Therapy of Bacterial Infection and Wound Healing

2021 ◽  
Author(s):  
Li Liu ◽  
Cheng Wang ◽  
Yuting Li ◽  
Lin Qiu ◽  
Shuwen Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Soft Tissue ◽  
Bacterial Infection ◽  
Manganese Dioxide ◽  
Soft Tissue Infection ◽  
Oxygen Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Central Effector

Reactive oxygen species (ROS) are the weapon of neutrophiles against bacterial pathogens, and also the central effector in the reactive oxygen therapy for skin and soft tissue infection. Nanozymes that...

Effect of HBO therapy on adipose-derived stem cells, fibroblasts and co-cultures: In vitro study of oxidative stress, angiogenic potential and production of pro-inflammatory growth factors in co-cultures1

2020 ◽  
pp. 1-13
Author(s):  
P. Engel ◽  
M. Ranieri ◽  
O. Felthaus ◽  
S. Geis ◽  
F. Haubner ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Wound Healing ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Reactive Oxygen ◽  
Adipose Derived Stem Cells ◽  
Oxygen Species

BACKGROUND: A key moderator of wound healing is oxygen. Wound healing is a dynamic and carefully orchestrated process involving blood cells, cytokines, parenchymal cells (i.e. fibroblasts and mesenchymal stem cells) and extracellular matrix reorganization. Human adipose derived stem cells as well as human fibroblasts produce soluble factors, exhibit diverse effects on inflammation and anti inflammation response and are involved in wound healing processes. Hyperbaric oxygen therapy is an effective adjunct treatment for ischemic disorders such as chronic infection or chronic wounds. In vitro effects of hyperbaric oxygen therapy on human cells were presented in many studies except for those on mono- and co-cultures of human adipose derived stem cells and fibroblasts. OBJECTIVE: The aim of this study was to investigate the effects of hyperbaric oxygen therapy on mono- and co-cultures of human adipose derived stem cells and fibroblasts. METHODS: Mono- and co-cultures from human adipose derived stem cells and fibroblasts were established. These cultures were exposed to hyperbaric oxygen therapy every 24 h for five consecutive days. Measuring experiments were performed on the first, third and fifth day. Therapy effects on the expression of VEGF, IL 6 and reactive oxygen species were investigated. RESULTS: After exposure to hyperbaric oxygen, cell culturess showed a significant increase in the expression of VEGF after 3 and 5 days. All cultures showed significantly reduced formation of reactive oxygen species throughout the experiments. The expression of IL-6 decreased during the experiment in mono-cultures of human adipose derived stem cells and co-cultures. In contrast, mono-cultures of human skin fibroblasts showed an overall significantly increased expression of IL-6. CONCLUSIONS: Hyperbaric oxygen therapy leads to immunmodulatory and proangiogenetic effects in a wound-like enviroment of adipose derived stem cells and fibroblasts.

Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities

2021 ◽  
Vol 124 ◽  
pp. 219-232 ◽  
Author(s):  
Hao Cheng ◽  
Zhe Shi ◽  
Kan Yue ◽  
Xusheng Huang ◽  
Yichuan Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

2014 ◽  
Vol 320 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Nina Tandon ◽  
Elisa Cimetta ◽  
Aranzazu Villasante ◽  
Nicolette Kupferstein ◽  
Michael D. Southall ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Dermal Fibroblasts ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts ◽  
Wound Healing Model ◽  
Healing Model

Bimetal Metal-Organic Framework Domino Micro-Reactor for Synergistic Antibacterial Starvation/Chemodynamic Therapy and Robust Wound Healing

Nanoscale ◽  
2022 ◽  
Author(s):  
Liming Peng ◽  
Xuyang Yang ◽  
Song Wang ◽  
Joseph Yau Kei Chan ◽  
Yong Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic ◽  
Micro Reactor ◽  
Organic Framework

Antibacterial chemodynamic therapy (aCDT) has captured considerable attention in the treatment of pathogen-induced infection due to its potential to inactivate bacteria through germicidal reactive oxygen species (ROS). However, the lifespan...

scholarly journals NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression

Cell Reports ◽  
2021 ◽  
Vol 37 (3) ◽  
pp. 109856
Author(s):  
Chetanchandra S. Joshi ◽  
Amy Mora ◽  
Paul A. Felder ◽  
Indira U. Mysorekar
Keyword(s):  
Reactive Oxygen Species ◽  
Bacterial Infection ◽  
Cell Response ◽  
Reactive Oxygen ◽  
Urothelial Cell ◽  
Oxygen Species

Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species

2006 ◽  
Vol 290 (1-2) ◽  
pp. 87-96 ◽  
Author(s):  
Manikandan Panchatcharam ◽  
Sumitra Miriyala ◽  
Vinaya Subramani Gayathri ◽  
Lonchin Suguna
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process

2015 ◽  
Vol 14 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Christopher Dunnill ◽  
Thomas Patton ◽  
James Brennan ◽  
John Barrett ◽  
Matthew Dryden ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Functional Role ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Oxygen Species
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