Visualization of USPIO-Labeled Melt-Electrowritten Scaffolds by Non-Invasive Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Kilian Maria Arthur Mueller ◽  
Geoffrey Topping ◽  
Sebastian Patrick Schwaminger ◽  
Younzhe Zou ◽  
Diana Marcela Rojas-González ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Tissue Engineering ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Digital Fabrication ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Forming Technology

Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in...

scholarly journals Magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage

2021 ◽  
Vol 8 (5) ◽  
Author(s):  
Xian Xu ◽  
Jingming Gao ◽  
Shuyun Liu ◽  
Liang Chen ◽  
Min Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
T2 Mapping ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Biomaterial Scaffold ◽  
Significant Difference

Abstract With the development of tissue engineering and regenerative medicine, it is much desired to establish bioimaging techniques to monitor the real-time regeneration efficacy in vivo in a non-invasive way. Herein, we tried magnetic resonance imaging (MRI) to evaluate knee cartilage regeneration after implanting a biomaterial scaffold seeded with chondrocytes, namely, matrix-induced autologous chondrocyte implantation (MACI). After summary of the T2 mapping and the T1-related delayed gadolinium-enhanced MRI imaging of cartilage (dGEMRIC) in vitro and in vivo in the literature, these two MRI techniques were tried clinically. In this study, 18 patients were followed up for 1 year. It was found that there was a significant difference between the regeneration site and the neighboring normal site (control), and the difference gradually diminished with regeneration time up to 1 year according to both the quantitative T1 and T2 MRI methods. We further established the correlation between the quantitative evaluation of MRI and the clinical Lysholm scores for the first time. Hence, the MRI technique was confirmed to be a feasible semi-quantitative yet non-invasive way to evaluate the in vivo regeneration of knee articular cartilage.

Magnetic resonance imaging using a clinical whole body system: an introduction to a useful technique in small animal experiments

1992 ◽  
Vol 26 (3) ◽  
pp. 222-227 ◽  
Author(s):  
R. F. E. Wolf ◽  
K. H. Lam ◽  
E. L. Mooyaart ◽  
R. P. Bleichrodt ◽  
P. Nieuwenhuis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Animal Studies ◽  
Animal Experiments ◽  
Small Animal ◽  
Whole Body ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Set Up

A clinical whole body magnetic resonance imaging (MRI) system with high resolution coils was used to obtain non-invasive images of the living rat. The results demonstrate the feasibility of the set-up and the advantages of this new imaging technique: detailed information, no extra costs, longitudinal studies without killing animals and simple anaesthesia. It is concluded that in small animal experimentation, this use of high resolution coils in whole body magnetic resonance systems may be particularly helpful in establishing effects of experimental procedures. Whenever non-invasive visualization is required, especially in longitudinal animal studies, e.g. biomaterial research or tumour investigation, this use of MRI will offer challenging possibilities.

scholarly journals Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3626
Author(s):  
Hannah Hornby ◽  
Mar Collado-González ◽  
Xue Zhang ◽  
Nichola Abrehart ◽  
Meshari Alshammari ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Median Number ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Healthy Humans ◽  
Magnetic Resonance Imaging Mri ◽  
First Time

Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vegetables (Meal 1), bread and jam (Meal 2) and cheese and yogurt (Meal 3), and then, their stomach content was imaged. The median number of boluses within the stomach was 282, 106 and 9 for Meal 1, Meal 2 and Meal 3 (p < 0.0001) with an average volume of 0.47 mL, 2.4 mL and 13.6 mL, respectively (p < 0.0001). The cohesiveness as well as the meal composition seem to play a key role in the resulting boluses. These new in vivo data from undisturbed organ imaging can improve knowledge of the digestion process, which will, in turn, inform in vitro and in silico modelling of digestion, thus improving their in vitro/in vivo relevance.

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