LC-HRMS Studies on Ruxolitinib Degradation: A Comprehensive Approach during Drug Development

2022 ◽  
Author(s):  
Kalyani Sharma ◽  
Harsh Thakkar ◽  
Nancy Goyal ◽  
Ravi P Shah
Keyword(s):  
Thermal Stress ◽  
Solid State ◽  
Drug Development ◽  
Comprehensive Approach ◽  
Solution State ◽  
Stress Studies

Ruxolitinib a kinases inhibitor, was subjected to stress studies as described in ICH Q1A(R2) guideline. Solution state hydrolytic and solid state oxidative and thermal stress studies were carried out to...

Proton-Detected NMR Spectroscopy of Nanodisc-Embedded Membrane Proteins: MAS Solid-State vs Solution-State Methods

2017 ◽  
Vol 121 (32) ◽  
pp. 7671-7680 ◽  
Author(s):  
Nils-Alexander Lakomek ◽  
Lukas Frey ◽  
Stefan Bibow ◽  
Anja Böckmann ◽  
Roland Riek ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Membrane Proteins ◽  
Solution State

Determination of extent of reaction in poly(mono- and dimethacrylates) using n.m.r. Comparison of solid-state and solution-state methods

Polymer ◽  
1997 ◽  
Vol 38 (9) ◽  
pp. 2041-2045 ◽  
Author(s):  
Frank Heatley ◽  
Majid Ali ◽  
John Godward ◽  
Karl Stonebank ◽  
David C. Watts ◽  
...  
Keyword(s):  
Solid State ◽  
Solution State

Ordered Solid‐State Microstructures of Conjugated Polymers Arising from Solution‐State Aggregation

2020 ◽  
Vol 132 (40) ◽  
pp. 17620-17624
Author(s):  
Ze‐Fan Yao ◽  
Zi‐Yuan Wang ◽  
Hao‐Tian Wu ◽  
Yang Lu ◽  
Qi‐Yi Li ◽  
...  
Keyword(s):  
Solid State ◽  
Conjugated Polymers ◽  
Solution State ◽  
State Aggregation

Solution- and solid-state photophysical and stimuli-responsive behavior in conjugated monoalkoxynaphthalene–naphthalimide donor–acceptor dyads

2015 ◽  
Vol 3 (46) ◽  
pp. 12156-12163 ◽  
Author(s):  
Cameron Peebles ◽  
Christopher D. Wight ◽  
Brent L. Iverson
Keyword(s):  
Solid State ◽  
Stimuli Responsive ◽  
Solution State ◽  
Donor Acceptor ◽  
Responsive Behavior

The solution-state, solid-state and exceptional stimuli-responsive properties of a series of aromatic conjugated monoalkoxynaphthalene–naphthalimide donor–acceptor dyads is reported.

Switching of Chiral Induction in Helical Aromatic Oligoamides Using Solid State−Solution State Equilibrium

2004 ◽  
Vol 126 (4) ◽  
pp. 1034-1035 ◽  
Author(s):  
Hua Jiang ◽  
Christel Dolain ◽  
Jean-Michel Léger ◽  
Heinz Gornitzka ◽  
Ivan Huc
Keyword(s):  
Solid State ◽  
State Solution ◽  
State Equilibrium ◽  
Chiral Induction ◽  
Solution State

Comparison of nuclear magnetic resonance methods for the analysis of organic matter composition from soil density and particle fractions

2012 ◽  
Vol 9 (1) ◽  
pp. 97 ◽  
Author(s):  
Joyce S. Clemente ◽  
Edward G. Gregorich ◽  
André J. Simpson ◽  
Rajeev Kumar ◽  
Denis Courtier-Murias ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Magnetic Resonance ◽  
1H Nmr ◽  
Solution State ◽  
Soil Fractions ◽  
13C Nuclear Magnetic Resonance ◽  
Nmr Methods ◽  
Solid State 13C Nmr ◽  
Nuclear Magnetic

Environmental contextThe association of specific organic matter (OM) compounds with clay mineral surfaces is believed to protect these compounds from degradation and thus result in long-term protection in soil. The molecular-level composition of soil OM associated with soil fractions was measured and compared using solid-state 13C nuclear magnetic resonance (NMR) and solution-state 1H NMR methods. Combining these methods allowed more detailed characterisation of OM associated with different soil fractions and will improve the understanding of OM dynamics in soil. AbstractOrganic matter (OM) associated with fine soil fractions is hypothesised to be protected from complete biodegradation by soil microbes. It is therefore important to understand the structure and stage of decomposition of OM associated with various soil fractions. Solid-state 13C nuclear magnetic resonance (NMR) spectroscopy has been used extensively to investigate the OM composition of soils and soil fractions. Solution-state 1H NMR spectroscopy has not been used as much but is an emerging tool for analysing soil OM because 1H NMR spectra are often better resolved and provide information that complements the structural information obtained from solid-state 13C NMR experiments. This study compares one-dimensional solution-state 1H NMR and solid-state 13C NMR methods for assessing the degradation and composition of OM in three different soils, and their light and clay-size fractions. The alkyl/O-alkyl degradation parameter was consistent across all NMR methods and showed that OM associated with clay-size fractions were at more advanced stages of degradation as compared to that in light density soil fractions. Solution-state 1H and diffusion edited (DE) 1H NMR results showed the presence of high concentrations of microbial-derived peptidoglycan and peptide side-chains in clay-sized fractions. Lignin was also identified in clay-sized fractions using solid-state 13C and solution-state 1H NMR techniques. The combination of solid-state 13C and solution-state 1H NMR methods provides a more detailed analysis of OM composition and thereby facilitates a better understanding of the fate and preservation of OM in soil.

Solution State NMR Techniques Applied to Solid State Samples: Characterization of Benzoic Acid Confined in MCM-41

2010 ◽  
Vol 114 (19) ◽  
pp. 8884-8891 ◽  
Author(s):  
Thierry Azais ◽  
Geoffrey Hartmeyer ◽  
Sandrine Quignard ◽  
Guillaume Laurent ◽  
Florence Babonneau
Keyword(s):  
Solid State ◽  
Benzoic Acid ◽  
Solution State ◽  
Nmr Techniques ◽  
Mcm 41
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