LC–MS3 strategy to determine lamotrigine by Q-Q-Trap tandem mass spectrometry coupled with triple stage fragmentation to enhance sensitivity and selectivity

2021 ◽  
Author(s):  
Meiyun Shi ◽  
Qiuhong Jiang ◽  
Qiushi Lyu ◽  
Zhengting Yuan ◽  
Lili Deng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
High Performance ◽  
Internal Standard ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Sensitivity And Selectivity

A high-performance liquid chromatography tandem mass spectrometry cubed (HPLC/ MS3) method was developed and validated to quantify lamotrigine in human plasma with carbamazepine as an internal standard. The HPLC/MS/MS system...

Measurement of serum testosterone using high-performance liquid chromatography/tandem mass spectrometry

2006 ◽  
Vol 44 (1) ◽  
Author(s):  
Faye B. Vicente ◽  
Frederick A. Smith ◽  
Rafael Sierra ◽  
Sihe Wang
Keyword(s):  
Mass Spectrometry ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
High Performance ◽  
Internal Standard ◽  
Serum Testosterone ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass

AbstractLow levels of serum testosterone typically found in women and children cannot be reliably measured by immunoassay. We developed a simple and sensitive method using high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). Sample preparation involved protein precipitation of serum (1.0mL) with acetonitrile containing the internal standard (testosterone-

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