Comparison and recent progress of Molecular Imprinting Technology and dummy template Molecular Imprinting Technology

2021 ◽  
Author(s):  
Runan Chen ◽  
Shu he Kang ◽  
Jia Li ◽  
Li na Lu ◽  
Xingping Luo ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Chromatographic Separation ◽  
Recent Progress ◽  
Molecular Imprinting Technology ◽  
Dummy Template ◽  
Recognition Function ◽  
Research Hotspots

Molecular Imprinting Technology for the preparation of polymers with specific molecular recognition function had become one of the current research hotspots. It had been widely applied in chromatographic separation, antibody...

scholarly journals Improved Enantioselectivity for Atenolol Employing Pivot Based Molecular Imprinting

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1875 ◽  
Author(s):  
Andreea Bodoki ◽  
Bogdan-Cezar Iacob ◽  
Laura Gliga ◽  
Simona Oprean ◽  
David Spivak ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Molecular Imprinting ◽  
Metal Ion ◽  
Chromatographic Retention ◽  
Central Metal ◽  
Functional Monomer ◽  
Recognition Mechanism ◽  
Functional Monomers ◽  
Chiral Compounds ◽  
Molecular Imprinting Technology

In the last few decades, molecular imprinting technology went through a spectacular evolution becoming a well-established tool for the synthesis of highly selective biomimetic molecular recognition platforms. Nevertheless, there is still room for advancement in the molecular imprinting of highly polar chiral compounds. The aim of the present work was to investigate the favorable kosmotropic effect of a ternary complex involving a polar chiral template (eutomer of atenolol) and a functional monomer, bridged by a central metal ion through well-defined, spatially directional coordinate bonds. The efficiency of the chiral molecular recognition was systematically assessed on polymers obtained both by non-covalent and metal-mediated molecular imprinting. The influence on the chromatographic retention and enantioselectivity of different experimental variables (functional monomers, cross-linkers, chaotropic agents, metal ions, porogenic systems, etc.) were studied on both slurry packed and monolithic HPLC columns. Deliberate changes in the imprinting and rebinding (chromatographic) processes, along with additional thermodynamic studies shed light on the particularities of the molecular recognition mechanism. The best performing polymer in terms of enantioselectivity (α = 1.60) was achieved using 4-vinyl pyridine as functional monomer and secondary ligand for the Co(II)-mediated imprinting of S-atenolol in the presence of EDMA as cross-linker in a porogenic mixture of [BMIM][BF4]:DMF:DMSO = 10:1:5, v/v/v.

Perspective of Organoboron Chemistry

Synlett ◽  
2021 ◽  
Author(s):  
Lingbing Kong ◽  
Chunming Cui
Keyword(s):  
Recent Progress ◽  
Main Group ◽  
Future Research ◽  
Materials Chemistry ◽  
Organoboron Compounds ◽  
The Future ◽  
Research Hotspots

Organoboron compounds play prominent roles in structural, synthetic and materials chemistry because the boron atoms may feature electrophilic, amphiphilic and nucleophilic characters. This perspective briefly describes the most recent progress in organoboron chemistry by focusing on both new advent boron molecules and their applications, which greatly inspire the interest of main group chemists. Meanwhile, the future research hotspots based on these pioneering results are also discussed.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

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