Simultaneous determination of three antituberculosis drugs in the serum of patients with spinal tuberculosis by capillary electrophoresis

2021 ◽  
Author(s):  
Xuehua Wu ◽  
Xiaoming Che ◽  
Zhixue Qiu ◽  
Jingyuan Chao ◽  
Zhanping Kong ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Simultaneous Determination ◽  
Spinal Tuberculosis ◽  
Serum Samples ◽  
Antituberculosis Drugs ◽  
Sensitive Method

Capillary electrophoresis is a simple, rapid, and sensitive method for measuring PZA (1), INH (2), and RFP (3) simultaneously in serum samples of patients with spinal tuberculosis.

Determination of alkaloids in Rhizoma coptidis by capillary electrophoresis with acidic potassium permanganate chemiluminescene detection

2015 ◽  
Vol 7 (3) ◽  
pp. 976-981 ◽  
Author(s):  
Xueqin Xu ◽  
Jingpeng Wang ◽  
Fuyu Wen ◽  
Guonan Chen
Keyword(s):  
Capillary Electrophoresis ◽  
Simultaneous Determination ◽  
Potassium Permanganate ◽  
Rhizoma Coptidis ◽  
Sensitive Method

A simple and sensitive method based on capillary electrophoresis (CE) with acidic potassium permanganate chemiluminescence (CL) detection has been developed for the simultaneous determination of three alkaloids (berberine, palmatine and jatrorrhizine) in Rhizoma coptidis.

Simultaneous Determination of Chloroquine and Pyrimethamine with Cetirizine in an Active Form and Human Serum by RP-HPLC

2021 ◽  
Author(s):  
Hina Shamshad ◽  
Ali Sayqal ◽  
Jahan Zeb ◽  
Agha Zeeshan Mirza
Keyword(s):  
Human Serum ◽  
Simultaneous Determination ◽  
Active Form ◽  
Internal Standard ◽  
Hplc Method ◽  
Serum Samples ◽  
Rp Hplc ◽  
Cetirizine Hydrochloride ◽  
Bulk Drug

Abstract A simple, accurate and precise RP-HPLC method was developed for the simultaneous determination of chloroquine, pyrimethamine and cetirizine hydrochloride concentrations in bulk drug and human serum. The assay was performed using a mobile phase of methanol: water (70:30) at pH of 2.8 ± 0.05 on the Purospher C-18 column with UV detection at 230 nm and rosuvastatin used as an internal standard. The retention times observed for chloroquine, pyrimethamine and cetirizine hydrochloride were 3.5, 2.5 and 5.5 minutes, respectively. The method was found to be specific for the assayed drugs showing a linear response in the concentration range of 1–100 μg mL−1 with coefficients of determination values of (r = 0.999). The method was developed and validated according to ICH guidelines. The method was used to monitor the serum samples and was found to be sensitive for therapeutic purposes, showing the potential to be a useful tool for routine analysis in laboratories.

Simultaneous determination of ascorbic and uric acids and dopamine in human serum samples using three-way calibration with data from square wave voltammetry

2016 ◽  
Vol 129 ◽  
pp. 205-212 ◽  
Author(s):  
Adrian Marcelo Granero ◽  
Gastón Darío Pierini ◽  
Sebastián Noel Robledo ◽  
María Susana Di Nezio ◽  
Héctor Fernández ◽  
...  
Keyword(s):  
Human Serum ◽  
Simultaneous Determination ◽  
Square Wave Voltammetry ◽  
Serum Samples ◽  
Square Wave ◽  
Human Serum Samples ◽  
Wave Voltammetry
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