Microfluidic Pressure in Paper (µPiP): Rapid Prototyping and Low-Cost Liquid Handling for On-Chip Diagnostics

The Analyst ◽  
2022 ◽  
Author(s):  
Md. Nazibul Islam ◽  
Jarad Yost ◽  
Zachary Gagnon
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Liquid Handling ◽  
Paper Based Microfluidics ◽  
Microfluidic Flows ◽  
On Chip

Paper-based microfluidics was initially developed for use in ultra-low-cost diagnostics powered passively by liquid wicking. However, there is significant untapped potential in using paper to internally guide porous microfluidic flows...

scholarly journals High-throughput rapid-prototyping of low-cost paper-based microfluidics

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Fariba Ghaderinezhad ◽  
Reza Amin ◽  
Mikail Temirel ◽  
Bekir Yenilmez ◽  
Adam Wentworth ◽  
...  
Keyword(s):  
Rapid Prototyping ◽  
High Throughput ◽  
Low Cost ◽  
Paper Based Microfluidics

Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay

2009 ◽  
Vol 30 (9) ◽  
pp. 1497-1500 ◽  
Author(s):  
Yao Lu ◽  
Weiwei Shi ◽  
Lei Jiang ◽  
Jianhua Qin ◽  
Bingcheng Lin
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Paper Based Microfluidics

Constructive Optimisation of the Propeller Type Mixing Devices Using the Virtual and Rapid Prototyping

2017 ◽  
Vol 68 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Daniel Besnea ◽  
Alina Spanu ◽  
Iuliana Marlena Prodea ◽  
Gheorghita Tomescu ◽  
Iolanda Constanta Panait
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Scale Up ◽  
Three Dimensional ◽  
Rapid Identification ◽  
Multidisciplinary Optimization ◽  
External Diameter ◽  
Process Industries ◽  
Parametric Cad ◽  
Shaft Torque

The paper points out the advantages of rapid prototyping for improving the performances/constructive optimization of mixing devices used in process industries, here exemplified to propeller types ones. The multidisciplinary optimization of the propeller profile affords its design using parametric CAD methods. Starting from the mathematical curve equations proposed for the blade profile, it was determined its three-dimensional virtual model. The challenge has been focused on the variation of propeller pitch and external diameter. Three dimensional ranges were manufactured using the additive manufacturing process with Marker Boot 3D printer. The mixing performances were tested on the mixing equipment measuring the minimum rotational speed and the correspondent shaft torque for complete suspension achieved for each of the three models. The virtual and rapid prototyping method is newly proposed by the authors to obtain the basic data for scale up of the mixing systems, in the case of flexible production (of low quantities), in which both the nature and concentration of the constituents in the final product varies often. It is an efficient and low cost method for the rapid identification of the optimal mixing device configuration, which contributes to the costs reduction and to the growing of the output.

scholarly journals Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Device for a Biosensor †

Sensors ◽  
2019 ◽  
Vol 19 (5) ◽  
pp. 1178 ◽  
Author(s):  
Jorge Prada ◽  
Christina Cordes ◽  
Carsten Harms ◽  
Walter Lang
Keyword(s):  
Microfluidic Device ◽  
Heating Temperature ◽  
Low Cost ◽  
Reaction Chamber ◽  
Microfluidic System ◽  
Heating Process ◽  
Design And Manufacturing ◽  
On Chip ◽  
Working Parameters ◽  
Auto Fluorescence

This contribution outlines the design and manufacturing of a microfluidic device implemented as a biosensor for retrieval and detection of bacteria RNA. The device is fully made of Cyclo-Olefin Copolymer (COC), which features low auto-fluorescence, biocompatibility and manufacturability by hot-embossing. The RNA retrieval was carried on after bacteria heat-lysis by an on-chip micro-heater, whose function was characterized at different working parameters. Carbon resistive temperature sensors were tested, characterized and printed on the biochip sealing film to monitor the heating process. Off-chip and on-chip processed RNA were hybridized with capture probes on the reaction chamber surface and identification was achieved by detection of fluorescence tags. The application of the mentioned techniques and materials proved to allow the development of low-cost, disposable albeit multi-functional microfluidic system, performing heating, temperature sensing and chemical reaction processes in the same device. By proving its effectiveness, this device contributes a reference to show the integration potential of fully thermoplastic devices in biosensor systems.

scholarly journals A Review of Current Research in Subscale Flight Testing and Analysis of Its Main Practical Challenges

Aerospace ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 74
Author(s):  
Alejandro Sobron ◽  
David Lundström ◽  
Petter Krus
Keyword(s):  
Literature Review ◽  
Research And Development ◽  
Rapid Prototyping ◽  
Experimental Method ◽  
Low Cost ◽  
Full Scale ◽  
Interesting Application ◽  
Flight Testing ◽  
Scale Characteristics ◽  
Vehicle Technologies

Testing of untethered subscale models, often referred to as subscale flight testing, has traditionally had a relatively minor, yet relevant use in aeronautical research and development. As recent advances in electronics, rapid prototyping and unmanned-vehicle technologies expand its capabilities and lower its cost, this experimental method is seeing growing interest across academia and the industry. However, subscale models cannot meet all similarity conditions required for simulating full-scale flight. This leads to a variety of approaches to scaling and to other alternative applications. Through a literature review and analysis of different scaling strategies, this study presents an overall picture of how subscale flight testing has been used in recent years and synthesises its main issues and practical limitations. Results show that, while the estimation of full-scale characteristics is still an interesting application within certain flight conditions, subscale models are progressively taking a broader role as low-cost technology-testing platforms with relaxed similarity constraints. Different approaches to tackle the identified practical challenges, implemented both by the authors and by other organisations, are discussed and evaluated through flight experiments.

On-Chip Fabrication of None-Dead-Volume Microtips for ESI-MS Applications

2007 ◽  
Vol 121-123 ◽  
pp. 611-614
Author(s):  
Che Hsin Lin ◽  
Jen Taie Shiea ◽  
Yen Lieng Lin
Keyword(s):  
Surface Tension ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Dead Volume ◽  
Esi Ms ◽  
Rapid Fabrication ◽  
Chip Fabrication ◽  
Novel Method ◽  
On Chip ◽  
Highly Uniform

This paper proposes a novel method to on-chip fabricate a none-dead-volume microtip for ESI-MS applications. The microfluidic chip and ESI tip are fabricated in low-cost plastic based materials using a simple and rapid fabrication process. A constant-speed-pulling method is developed to fabricate the ESI tip by pulling mixed PMMA glue using a 30-μm stainless wire through the pre-formed microfluidic channel. The equilibrium of surface tension of PMMA glue will result in a sharp tip after curing. A highly uniform micro-tip can be formed directly at the outlet of the microfluidic channel with minimum dead-volume zone. Detection of caffeine, myoglobin, lysozyme and cytochrome C biosamples confirms the microchip device can be used for high resolution ESI-MS applications.

Optical MEMS platform for low-cost on-chip integration of planar light circuits and optical switching

2004 ◽  
Author(s):  
Kristine A. German ◽  
Joel Kubby ◽  
Jingkuang Chen ◽  
James Diehl ◽  
Kathleen Feinberg ◽  
...  
Keyword(s):  
Optical Switching ◽  
Low Cost ◽  
Optical Mems ◽  
On Chip

scholarly journals The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1467
Author(s):  
Harry Dawson ◽  
Jinane Elias ◽  
Pascal Etienne ◽  
Sylvie Calas-Etienne
Keyword(s):  
Low Cost ◽  
Optical Components ◽  
New Era ◽  
Lab On Chip ◽  
Highly Sensitive ◽  
Multiple Challenges ◽  
On Chip ◽  
Optical Circuits ◽  
Made In

The integration of optical circuits with microfluidic lab-on-chip (LoC) devices has resulted in a new era of potential in terms of both sample manipulation and detection at the micro-scale. On-chip optical components increase both control and analytical capabilities while reducing reliance on expensive laboratory photonic equipment that has limited microfluidic development. Notably, in-situ LoC devices for bio-chemical applications such as diagnostics and environmental monitoring could provide great value as low-cost, portable and highly sensitive systems. Multiple challenges remain however due to the complexity involved with combining photonics with micro-fabricated systems. Here, we aim to highlight the progress that optical on-chip systems have made in recent years regarding the main LoC applications: (1) sample manipulation and (2) detection. At the same time, we aim to address the constraints that limit industrial scaling of this technology. Through evaluating various fabrication methods, material choices and novel approaches of optic and fluidic integration, we aim to illustrate how optic-enabled LoC approaches are providing new possibilities for both sample analysis and manipulation.

Sign in / Sign up

Export Citation Format

Share Document