A thiocarbonate-caged fluorescent probe for specific visualization of peroxynitrite in living cells and zebrafish

The Analyst ◽  
2021 ◽  
Author(s):  
Fangyun Xin ◽  
Jiwei Zhao ◽  
Wei Shu ◽  
Xiaoling Zhang ◽  
Xixian Luo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Neurodegenerative Diseases ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species

Peroxynitrite (ONOO‒), a highly reactive oxygen species (ROS), is implicated with many physiological and pathological processes including cancer, neurodegenerative diseases and inflammation. In this regard, developing effective tools for highly...

Colorimetric and Fluorescent Probe for Hypochlorite with High Selectivity

2013 ◽  
Vol 295-298 ◽  
pp. 475-478 ◽  
Author(s):  
Zhi Xiang Han ◽  
Ming Hui Du ◽  
Guo Xi Liang ◽  
Xiang Yang Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Rhodamine B ◽  
High Selectivity ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Turn On

Rhodamine B thiohydrazide (RBS) was firstly employed as turn-on fluorescent probe for hypochlorite in aqueous solution and living cells. It exhibits a stable response to hypochlorite from 1.0×10-6to 1.0×10-5M with a detection limit of 3.3×10-7M. The response of this probe to hypochlorite is fast and highly selective compared with other reactive oxygen species (such as.OH,1O2, H2O2) and other common anions (such as X-, ClO2-, ClO4-, NO3-, NO2-, OH-, Ac-, CO32-, SO42-).

scholarly journals Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model

RSC Advances ◽  
2021 ◽  
Vol 11 (39) ◽  
pp. 24032-24037
Author(s):  
Rongrong Zhou ◽  
Qiyao Peng ◽  
Dan Wan ◽  
Chao Yu ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Oxidation Properties ◽  
Ratiometric Fluorescent Probe ◽  
Destructive Oxidation

Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS) with unique destructive oxidation properties, can be produced in lysosomes to fight off pathogens.

Fabrication of a fluorescent probe for reversibly monitoring mitochondrial membrane potential in living cells

2021 ◽  
Vol 13 (14) ◽  
pp. 1715-1719
Author(s):  
Dingyi Guo ◽  
Jie Sun ◽  
Minggang Tian ◽  
Weiying Lin
Keyword(s):  
Reactive Oxygen Species ◽  
Membrane Potential ◽  
Fluorescent Probe ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane ◽  
Cell Damage ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species

A fluorescent probe for reversibly monitoring mitochondrial membrane potential in living cells has been constructed successfully, which could be employed to visualize cell damage by reactive oxygen species.

Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation

2021 ◽  
Author(s):  
Qian Wu ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Organelle Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of...

A charge transfer assisted fluorescent probe for selective detection of hydrogen peroxide among different reactive oxygen species

2012 ◽  
Vol 48 (39) ◽  
pp. 4719 ◽  
Author(s):  
Manoj Kumar ◽  
Naresh Kumar ◽  
Vandana Bhalla ◽  
Parduman Raj Sharma ◽  
Yasrib Qurishi
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Charge Transfer ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Selective Detection ◽  
Oxygen Species ◽  
A Charge

scholarly journals Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reducedα-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Nikolaus Berndt ◽  
Sascha Bulik ◽  
Hermann-Georg Holzhütter
Keyword(s):  
Reactive Oxygen Species ◽  
Neurodegenerative Diseases ◽  
Neuronal Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Energy Metabolism ◽  
Atp Production ◽  
Dependent Inactivation ◽  
The Impact ◽  
Ketoglutarate Dehydrogenase

Reduced activity of brain α-ketoglutarate dehydrogenase complex (KGDHC) occurs in a number of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. In order to quantify the relation between diminished KGDHC activity and the mitochondrial ATP generation, redox state, transmembrane potential, and generation of reactive oxygen species (ROS) by the respiratory chain (RC), we developed a detailed kinetic model. Model simulations revealed a threshold-like decline of the ATP production rate at about 60% inhibition of KGDHC accompanied by a significant increase of the mitochondrial membrane potential. By contrast, progressive inhibition of the enzyme aconitase had only little impact on these mitochondrial parameters. As KGDHC is susceptible to ROS-dependent inactivation, we also investigated the reduction state of those sites of the RC proposed to be involved in ROS production. The reduction state of all sites except one decreased with increasing degree of KGDHC inhibition suggesting an ROS-reducing effect of KGDHC inhibition. Our model underpins the important role of reduced KGDHC activity in the energetic breakdown of neuronal cells during development of neurodegenerative diseases.

scholarly journals Real-time visualizing the regulation of reactive oxygen species on Zn2+ release in cellular lysosome by a specific fluorescent probe

2018 ◽  
Vol 264 ◽  
pp. 419-425 ◽  
Author(s):  
Zhangjun Hu ◽  
Guanqing Yang ◽  
Jiwen Hu ◽  
Hui Wang ◽  
Peter Eriksson ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Real Time ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Oxygen Species
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