An Ultrasensitive Electrochemical Sensor for the Detection of Acetaminophen via a Three-Dimensional Hierarchical Nanoporous Gold Wire Electrode

The Analyst ◽  
2021 ◽  
Author(s):  
Lanting Qian ◽  
Reem Elmahdy ◽  
Antony Raj Thiruppathi ◽  
Aicheng Chen
Keyword(s):  
Electrochemical Sensor ◽  
Three Dimensional ◽  
Gold Wire ◽  
Nanoporous Gold ◽  
Wire Electrode ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Acetaminophen is one of the most commonly used non-steroidal anti-inflammatory drugs worldwide. However, due to the increasing popularity of this drug, overdosing and the contamination of ambient waterways have emerged...

scholarly journals Modulating the Chemical and Biological Properties of Cancer Stem Cell-Potent Copper(II)-Nonsteroidal Anti-Inflammatory Drug Complexes

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1677 ◽  
Author(s):  
Shin ◽  
Eskandari ◽  
Suntharalingam
Keyword(s):  
Three Dimensional ◽  
Biological Properties ◽  
Culture Studies ◽  
Apoptosis Pathway ◽  
Cytotoxicity Studies ◽  
Ic50 Value ◽  
Low Toxicity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Micromolar Range

Copper(II) complexes bearing nonsteroidal anti-inflammatory drugs (NSAIDs) are known to potently kill cancer stem cells (CSCs), a subpopulation of tumour cells with high metastatic and relapse fidelity. One of the major disadvantages associated to these copper(II) complexes is their instability in the presence of strong cellular reductants (such as ascorbic acid). Here we present a biologically stable copper(II)-NSAID complex containing a bathocuproinedisulfonic acid disodium ligand and two indomethacin moieties, Cu(bathocuproinedisulfonic acid disodium)(indomethacin)2, 2. The copper(II) complex, 2 kills bulk breast cancer cells and breast CSC equally (in the sub-micromolar range) and displays very low toxicity against non-tumorigenic breast and kidney cells (IC50 value > 100 µM). Three-dimensional cell culture studies show that 2 can significantly reduce the number and size of breast CSC mammospheres formed (from single suspensions) to a similar level as salinomycin (an established anti-breast CSC agent). The copper(II) complex, 2 is taken up reasonably by breast CSCs and localises largely in the cytoplasm (>90%). Cytotoxicity studies in the presence of specific inhibitors suggest that 2 induces CSC death via a reactive oxygen species (ROS) and cyclooxygenase isoenzyme-2 (COX-2) dependent apoptosis pathway.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

Sign in / Sign up

Export Citation Format

Share Document