Recent Progress in Functional Peptides Designed for Tumor-targeted Imaging and Therapy

2021 ◽  
Author(s):  
Xingyu Wang ◽  
Yi-Hui Wang ◽  
Zhen Song ◽  
Xin-Yuan Hu ◽  
Jiping Wei ◽  
...  
Keyword(s):  
Recent Progress ◽  
Targeted Imaging ◽  
Medical Field ◽  
Diagnosis And Therapy ◽  
Low Toxicity ◽  
Functional Peptides ◽  
Living Organisms

The diagnosis and therapy of tumors are challenging problems in the medical field. Peptides are derived from living organisms with excellent biocompatibility, low-toxicity/non-toxicity, and negligible immunogenicity, and they have been...

Potential of Nanoparticles in Combating Candida Infections

2019 ◽  
Vol 16 (5) ◽  
pp. 478-491 ◽  
Author(s):  
Faizan Abul Qais ◽  
Mohd Sajjad Ahmad Khan ◽  
Iqbal Ahmad ◽  
Abdullah Safar Althubiani
Keyword(s):  
Targeted Delivery ◽  
Recent Progress ◽  
Antifungal Agents ◽  
Fungal Infections ◽  
Fold Increase ◽  
Antifungal Drugs ◽  
Low Toxicity ◽  
Candida Infections ◽  
Made In

Aims: The aim of this review is to survey the recent progress made in developing the nanoparticles as antifungal agents especially the nano-based formulations being exploited for the management of Candida infections. Discussion: In the last few decades, there has been many-fold increase in fungal infections including candidiasis due to the increased number of immunocompromised patients worldwide. The efficacy of available antifungal drugs is limited due to its associated toxicity and drug resistance in clinical strains. The recent advancements in nanobiotechnology have opened a new hope for the development of novel formulations with enhanced therapeutic efficacy, improved drug delivery and low toxicity. Conclusion: Metal nanoparticles have shown to possess promising in vitro antifungal activities and could be effectively used for enhanced and targeted delivery of conventionally used drugs. The synergistic interaction between nanoparticles and various antifungal agents have also been reported with enhanced antifungal activity.

scholarly journals Recent advances in skin collagen: functionality and non-medical applications

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Yanting Han ◽  
Jinlian Hu ◽  
Gang Sun
Keyword(s):  
Smart Materials ◽  
High Performance ◽  
Preparation Method ◽  
Chemical Reactivity ◽  
Medical Field ◽  
Recent Advances ◽  
Synthetic Materials ◽  
Skin Collagen ◽  
Promising Area ◽  
Living Organisms

Abstract During nature evolution process, living organisms have gradually adapted to the environment and been adept in synthesizing high performance structural materials at mild conditions by using fairly simple building elements. The skin, as the largest organ of animals, is such a representative example. Conferred by its intricate organization where collagen fibers are arranged in a randomly interwoven network, skin collagen (SC), defined as a biomass derived from skin by removing non-collagen components displays remarkable performance with combinations of mechanical properties, chemical-reactivity and biocompatibility, which far surpasses those of synthetic materials. At present, the application of SC in medical field has been largely studied, and there have been many reviews summarizing these efforts. However, the generalized view on the aspects of SC as smart materials in non-medical fields is still lacking, although SC has shown great potential in terms of its intrinsic properties and functionality. Hence, this review will provide a comprehensive summary that integrated the recent advances in SC, including its preparation method, structure, reactivity, and functionality, as well as applications, particularly in the promising area of smart materials. Graphical abstract

scholarly journals Lipid vesicles: applications, principal components and methods used in their formulations: A review

2020 ◽  
Vol 25 (2) ◽  
pp. 339-352
Author(s):  
Cicera Janaine Janaine Camilo ◽  
Débora Odilia Duarte Leite ◽  
Angelo Roncalli Alves Silva ◽  
Irwin Rose Alencar Menezes ◽  
Henrique Douglas Melo Coutinho ◽  
...  
Keyword(s):  
Lipid Vesicles ◽  
Phospholipid Bilayer ◽  
Future Research ◽  
Ionic Surfactants ◽  
Medical Field ◽  
Lipophilic Compounds ◽  
Ideal Composition ◽  
Low Toxicity ◽  
Main Components ◽  
The Ideal

Liposomes and niosomes are currently the most studied lipid vesicles in the nanomedicine field. The system formed by a phospholipid bilayer in aqueous medium allows these vesicles to carry both hydrophilic and lipophilic compounds, providing an increase in solubility of drugs lready used in conventional therapy. The focus on the development of these vesicles should be directed to determining the ideal composition, with low toxicity, biocompatibility and which remains stable for long periods. These characteristics are related to the components used for formulation and the substances that will be encapsulated. Another important point relates to the methods used during formulation, which are important in determining the type of vesicle formed, whether these be large or small, unilamellar or multilamellar. Because of the deliberate actions applied in the development of these vesicles, this review sought to gather updated information regarding the different methods used, including their main components while considering the behavior of each of them when used in different formulations. Also, data showing the importance of formulations in the medical field evidencing studies performed with liposome and niosome vesicles as promising in this area, and others, were included. The approach allows a better understanding of the participation of components in formulations such as cholesterol and non-ionic surfactants, as well as the basis for choosing the ideal components and methods for future research in the development of these vesicles.

scholarly journals Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 855 ◽  
Author(s):  
Zubair Ahmed Ratan ◽  
Mohammad Faisal Haidere ◽  
Md. Nurunnabi ◽  
Sadi Md. Shahriar ◽  
A.J. Saleh Ahammad ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Anticancer Agents ◽  
Recent Progress ◽  
Silver Ions ◽  
Cost Effective ◽  
Disease Diagnosis ◽  
Organic Nanoparticles ◽  
Anticancer Effects ◽  
Living Organisms ◽  
Bacteria And Fungi

Nanobiotechnology has grown rapidly and become an integral part of modern disease diagnosis and treatment. Biosynthesized silver nanoparticles (AgNPs) are a class of eco-friendly, cost-effective and biocompatible agents that have attracted attention for their possible biomedical and bioengineering applications. Like many other inorganic and organic nanoparticles, such as AuNPs, iron oxide and quantum dots, AgNPs have also been widely studied as components of advanced anticancer agents in order to better manage cancer in the clinic. AgNPs are typically produced by the action of reducing reagents on silver ions. In addition to numerous laboratory-based methods for reduction of silver ions, living organisms and natural products can be effective and superior source for synthesis of AgNPs precursors. Currently, plants, bacteria and fungi can afford biogenic AgNPs precursors with diverse geometries and surface properties. In this review, we summarized the recent progress and achievements in biogenic AgNPs synthesis and their potential uses as anticancer agents.

scholarly journals Application of Nucleic Acid Frameworks in the Construction of Nanostructures and Cascade Biocatalysts: Recent Progress and Perspective

2022 ◽  
Vol 9 ◽  
Author(s):  
Gan Zhu ◽  
Ping Song ◽  
Jing Wu ◽  
Minglan Luo ◽  
Zhipeng Chen ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Recent Progress ◽  
Cascade Reactions ◽  
Molecular Structures ◽  
Potential Contribution ◽  
Enzyme Systems ◽  
Structures And Properties ◽  
Living Organisms ◽  
Future Direction

Nucleic acids underlie the storage and retrieval of genetic information literally in all living organisms, and also provide us excellent materials for making artificial nanostructures and scaffolds for constructing multi-enzyme systems with outstanding performance in catalyzing various cascade reactions, due to their highly diverse and yet controllable structures, which are well determined by their sequences. The introduction of unnatural moieties into nucleic acids dramatically increased the diversity of sequences, structures, and properties of the nucleic acids, which undoubtedly expanded the toolbox for making nanomaterials and scaffolds of multi-enzyme systems. In this article, we first introduce the molecular structures and properties of nucleic acids and their unnatural derivatives. Then we summarized representative artificial nanomaterials made of nucleic acids, as well as their properties, functions, and application. We next review recent progress on constructing multi-enzyme systems with nucleic acid structures as scaffolds for cascade biocatalyst. Finally, we discuss the future direction of applying nucleic acid frameworks in the construction of nanomaterials and multi-enzyme molecular machines, with the potential contribution that unnatural nucleic acids may make to this field highlighted.

scholarly journals The role of metabolomics in myocardial infarction: a recent mini-review

2021 ◽  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Emergency Medicine ◽  
Cardiovascular Events ◽  
Recent Past ◽  
Medical Field ◽  
Current Article ◽  
Living Organisms ◽  
Related Mortality

Myocardial infarction (MI) is one of the most common and important causes of heart failure in critical care and emergency medicine. Incidence of MI and MI-related mortality have been on the rise in the recent past. Metabolomics is a new field that entails analysis of profiles of metabolites (<1250 Da) in living organisms. Currently, several studies have extensively explored the application of metabolomics in medical field. In the current article, the emerging applications of next-generation metabolomics on MI in the previous 10 years were reviewed. The present article thus provides references for further use of metabolomics to guide clinical treatment and provides a basis for prevention of cardiovascular events.

Advances in biopolymer composites and biomaterials for the removal of emerging contaminants

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Dayana Priyadharhsini Stephen ◽  
Suresh Babu Palanisamy
Keyword(s):  
Electrostatic Interactions ◽  
Membrane Filtration ◽  
Emerging Contaminants ◽  
Toxic Substances ◽  
Industrial Activities ◽  
Efficient Reduction ◽  
Low Toxicity ◽  
Living Organisms ◽  
Pathogens Removal

Abstract Domestic, agriculture, and industrial activities contaminate the waterbodies by releasing toxic substances and pathogens. Removal of pollutants from wastewater is critical to ensuring the quality of accessible water resources. Several wastewater treatments are often used. Researchers are increasingly focusing on adsorption, ion exchange, electrostatic interactions, biodegradation, flocculation, and membrane filtration for the efficient reduction of pollutants. Biopolymers are a combination of two or more products produced by the living organisms used to give the desired finished product with a unique attribute. Biomaterials are also similar to traditional polymers by having higher flexibility, biodegradability, low toxicity, and nontoxic secondary byproducts producing ability. Grafting, functionalization, and crosslinking will be used to enhance the characteristics of biopolymers. The present chapter will illustrate some of the important biopolymers and its compos that will impact wastewater treatment in the future. Most commonly used biopolymers including chitosan (CS), activated carbon (AC), carbon-nanotubes (CNTs), and graphene oxide (GO) are discussed. Finally, the opportunities and difficulties for applying adsorbents to water pollution treatment are discussed.

Future potential of osmium complexes as anticancer drug candidates, photosensitizers and organelle-targeted probes

2018 ◽  
Vol 47 (42) ◽  
pp. 14841-14854 ◽  
Author(s):  
Pingyu Zhang ◽  
Huaiyi Huang
Keyword(s):  
Photodynamic Therapy ◽  
Anticancer Drug ◽  
Anticancer Agents ◽  
Recent Progress ◽  
Targeted Imaging ◽  
Drug Candidates ◽  
Modes Of Action ◽  
Imaging Probes ◽  
Osmium Complexes ◽  
Future Potential

Here we summarize recent progress in the design and application of innovative osmium compounds as anticancer agents with diverse modes of action, as organelle-targeted imaging probes and photosensitizers for photodynamic therapy.

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