Elaborately manufacturing an electrochemical aptasensor based on gold nanoparticle/COF composites for amplified detection performance

2020 ◽  
Vol 8 (47) ◽  
pp. 16984-16991
Author(s):  
Qian-Qian Zhu ◽  
Wen-Wen Zhang ◽  
Han-Wen Zhang ◽  
Rongrong Yuan ◽  
Hongming He
Keyword(s):  
Gold Nanoparticle ◽  
Electrochemical Detection ◽  
Detection Performance ◽  
Electrochemical Aptasensor

An electrochemical aptasensor based on Au@COF is designed and fabricated with excellent electrochemical detection performance.

scholarly journals DNA tetrahedron-mediated immune-sandwich assay for rapid and sensitive detection of PSA through a microfluidic electrochemical detection system

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dezhi Feng ◽  
Jing Su ◽  
Yi Xu ◽  
Guifang He ◽  
Chenguang Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Reaction Time ◽  
Electrochemical Detection ◽  
Detection System ◽  
Detection Performance ◽  
Pdms Layer ◽  
Microfluidic Chips ◽  
Serum Samples ◽  
Gold Nanoflowers ◽  
Dna Tetrahedron

AbstractProstate-specific antigen (PSA) is the most widely used biomarker for the early diagnosis of prostate cancer. Existing methods for PSA detection are burdened with some limitations and require improvement. Herein, we developed a novel microfluidic–electrochemical (μFEC) detection system for PSA detection. First, we constructed an electrochemical biosensor based on screen-printed electrodes (SPEs) with modification of gold nanoflowers (Au NFs) and DNA tetrahedron structural probes (TSPs), which showed great detection performance. Second, we fabricated microfluidic chips by DNA TSP-Au NF-modified SPEs and a PDMS layer with designed dense meandering microchannels. Finally, the μFEC detection system was achieved based on microfluidic chips integrated with the liquid automatic conveying unit and electrochemical detection platform. The μFEC system we developed acquired great detection performance for PSA detection in PBS solution. For PSA assays in spiked serum samples of the μFEC system, we obtained a linear dynamic range of 1–100 ng/mL with a limit of detection of 0.2 ng/mL and a total reaction time <25 min. Real serum samples of prostate cancer patients presented a strong correlation between the “gold-standard” chemiluminescence assays and the μFEC system. In terms of operation procedure, cost, and reaction time, our method was superior to the current methods for PSA detection and shows great potential for practical clinical application in the future.

scholarly journals Electrochemical detection of plant virus using gold nanoparticle-modified electrodes

2019 ◽  
Vol 1046 ◽  
pp. 123-131 ◽  
Author(s):  
Mohga Khater ◽  
Alfredo de la Escosura-Muñiz ◽  
Daniel Quesada-González ◽  
Arben Merkoçi
Keyword(s):  
Gold Nanoparticle ◽  
Electrochemical Detection ◽  
Plant Virus ◽  
Modified Electrodes

Electrochemical Detection of Tributyrin using Gold Nanoparticle Functionalized Screen-Printed Electrode

2021 ◽  
Author(s):  
A. Aidil ◽  
S. R. Balakrishnan ◽  
C.W. Zanariah ◽  
W.Z. Wan Ismail ◽  
M. Sahrim ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Electrochemical Detection ◽  
Screen Printed Electrode ◽  
Screen Printed

Gold nanoparticle/DNA-based nanobioconjugate for electrochemical detection of Zika virus

2020 ◽  
Vol 187 (11) ◽  
Author(s):  
Sebastian Cajigas ◽  
Daniel Alzate ◽  
Jahir Orozco
Keyword(s):  
Gold Nanoparticle ◽  
Electrochemical Detection ◽  
Zika Virus
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