Recent progress in efficient organic two-photon dyes for fluorescence imaging and photodynamic therapy

2020 ◽  
Vol 8 (19) ◽  
pp. 6342-6349 ◽  
Author(s):  
Liang Xu ◽  
Junzheng Zhang ◽  
Lingfeng Yin ◽  
Xueting Long ◽  
Wenying Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Fluorescence Quantum Yield ◽  
Organic Dyes ◽  
Photon Absorption ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

The enhancement of two-photon absorption cross-section, fluorescence quantum yield and singlet oxygen generation efficiency for organic dyes and their applications in two-photon excited fluorescence imaging and photodynamic therapy are summarized.

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

2014 ◽  
Vol 127 (1) ◽  
pp. 171-175 ◽  
Author(s):  
Julie Schmitt ◽  
Valérie Heitz ◽  
Angélique Sour ◽  
Frédéric Bolze ◽  
Hussein Ftouni ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

scholarly journals Nitric oxide activatable photosensitizer accompanying extremely elevated two-photon absorption for efficient fluorescence imaging and photodynamic therapy

2018 ◽  
Vol 9 (4) ◽  
pp. 999-1005 ◽  
Author(s):  
Wenbo Hu ◽  
Meng Xie ◽  
Hui Zhao ◽  
Yufu Tang ◽  
Song Yao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon

A nitric oxide (NO) activatable photosensitizer was constructed for efficient fluorescence imaging and photodynamic therapy.

Singlet Oxygen Generation and Photocytotoxicity against Tumor Cell by Two-Photon Absorption

2007 ◽  
Vol 471 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Kazuya Ogawa ◽  
Joanne T. Dy ◽  
Yoshiaki Kobuke ◽  
Shun-ichiro Ogura ◽  
Ichiro Okura
Keyword(s):  
Tumor Cell ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

Cooperative porphyrin-quadrupolar based triad for combined two-photon induced fluorescence and singlet oxygen generation

2017 ◽  
Vol 21 (02) ◽  
pp. 77-87 ◽  
Author(s):  
Jean-Baptiste Verlhac ◽  
Guillaume Clermont ◽  
Mireille Blanchard-Desce
Keyword(s):  
Singlet Oxygen ◽  
Photon Absorption ◽  
Absorption Properties ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Design And Synthesis ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Potential Applications ◽  
Order Of Magnitude

The design and synthesis of a cooperative multichromophoric triad system which combines the large two-photon absorption properties of fluorene-cored bis-donor quadropolar dyes and the remarkable sensitizing properties of the porphyrin subunit (i.e. high intersystem crossing and ability to produce singlet oxygen by energy transfer to oxygen from its triplet excited state) is described. After irradiation the energy can be transferred from the quadrupolar chromophores to the porphyrin with an estimated 80% efficiency via a FRET process. Moreover both the two-photon absorption properties of the quadrupolar subunits and the sensitizing and fluorescence properties of the porphyrin are retained indicating that deleterious competing processes (such as photo-induced electron transfer) are prevented in such molecular architectures thanks to the implemented design. As a result, the two-photon absorption induced singlet oxygen generation efficiency of the triad in the NIR region is found to be enhanced by an order of magnitude as compared to the porphyin subunit. Potential applications of these porphyrin-based multichromophoric systems for photodynamic therapy based upon two-photon excitation in the NIR region might be possible since it overcomes the low two-photon absorption response of porphyrin while fully retaining their remarkable photosensitizing properties.

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