The application of amide units in the construction of neutral functional dyes for mitochondrial staining

2021 ◽  
Vol 9 (10) ◽  
pp. 2524-2531
Author(s):  
Wei Ma ◽  
Bing Xu ◽  
Ru Sun ◽  
Yu-Jie Xu ◽  
Jian-Feng Ge
Keyword(s):  
Fluorescent Dyes ◽  
Nile Red ◽  
Suzuki Coupling ◽  
Coupling Reactions ◽  
New Class ◽  
Functional Dyes ◽  
Mitochondrial Staining

To develop a new class of neutral fluorescent dyes with mitochondrial staining capacity, a series of functional dyes were obtained from Nile red (2a–e) and coumarin (3a–e) with different amide compounds via Suzuki coupling reactions.

Benzothiadiazole-oligothiophene flanked dicyanomethylenated quinacridone for non-fullerene acceptors in polymer solar cells

2018 ◽  
Vol 42 (7) ◽  
pp. 5005-5013 ◽  
Author(s):  
Junjun Su ◽  
Xin Wen ◽  
Weiping Chen ◽  
Yang Miao ◽  
Fenghong Li ◽  
...  
Keyword(s):  
Solar Cells ◽  
Good Yield ◽  
Knoevenagel Condensation ◽  
Polymer Solar Cells ◽  
Suzuki Coupling ◽  
Coupling Reactions ◽  
New Class

A new class of benzothiadiazole-oligo(3-hexylthiophene) flanked dicyanomethylenated quinacridone derivatives DCNQA-BT-Tn (n = 1–3) has been designed and synthesized in good yield by iterative bromination and Suzuki coupling reactions, followed by Knoevenagel condensation.

En face dual fluorescence staining of fatty streaks allows observation of initiation and progression of atherosclerotic lesions

1995 ◽  
Vol 53 ◽  
pp. 864-865
Author(s):  
Anne M. Klinkner ◽  
Crystal R. Waites ◽  
Peter J. Bugelski ◽  
William D. Kerns
Keyword(s):  
Fluorescent Dyes ◽  
Nile Red ◽  
Dimethyl Formamide ◽  
High Cholesterol Diet ◽  
Methods Development ◽  
Atherosclerotic Lesions ◽  
En Face ◽  
Biochemical Evaluation ◽  
Stock Solutions ◽  
Dual Staining

A primary effort in the understanding of the progression of atherosclerotic disease has been methods development for visualization of the atherosclerotic plaque. We introduce a new method for the qualitative analysis of lipids in atherosclerotic fatty streaks which also retains those lipids for biochemical evaluation. An original aspect of the process is the ability to view an entire fatty streak en face, selectively stained for specific lipid classes within the lesion.New Zealand white rabbits were fed a high cholesterol diet(0.15%-0.3% for 14 wks). The aorta was removed and fixed in Carson's phosphate buffered formaldehyde followed by dual staining in the fluorescent dyes Nile red and filipin. Stock solutions of nile red(0.5mg/ml acetone) and filipin(2.5mg/ml dimethyl formamide) were prepared and kept at -20°C; all subsequent steps were at RT. 0.5cm × 1.0cm pieces of aorta were trimmed and adventitia removed. The pieces were then washed 3×15 min in PBS w/o CaMg, soaked in Nile red(NR)/filipin(Fl) stain(100(il NR stock + 200μl Fl stock in 10 ml PBS for 30 min, washed in PBS 3×30 min, rinsed with distilled water, mounted(Crystal Mount, Biomedia) and coverslipped and viewed by fluorescence microscopy.

SYNTHESES OF A NEW CLASS OF DYES-COUPLING REACTIONS OF DIAZONIUM SALTS WITH 2- AND 3-ALKOXY-1,6-METHANO-[10]-ANNULENES

1983 ◽  
Vol 12 (5) ◽  
pp. 653-656 ◽  
Author(s):  
Richard Neidlein ◽  
Christoph Martin Radke ◽  
Reiner Gottfried
Keyword(s):  
Diazonium Salts ◽  
Coupling Reactions ◽  
New Class

ChemInform Abstract: Synthesis of Triphenylamine-Modified Arylates and Ketones via Suzuki Coupling Reactions.

ChemInform ◽  
2011 ◽  
Vol 42 (32) ◽  
pp. no-no
Author(s):  
Jian Wang ◽  
Chang-Jian Yang ◽  
Hua-Nan Peng ◽  
Yang-Sheng Deng ◽  
Xi-Cun Gao
Keyword(s):  
Suzuki Coupling ◽  
Coupling Reactions

The Synthesis and Catalytic Application of a New Class of Imprinted Silica

2003 ◽  
Vol 787 ◽  
Author(s):  
John D. Bass ◽  
Sandra L. Anderson ◽  
Alexander Katz
Keyword(s):  
Rational Design ◽  
Chemical Reactivity ◽  
Phenylboronic Acid ◽  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Outer Sphere ◽  
Suzuki Coupling Reaction ◽  
New Class ◽  
Catalytic Application ◽  
Rate Acceleration

AbstractThe effect of chemical environment surrounding a synthetic heterogeneous catalyst active site is investigated using the hydrophilic imprinting of silica. Two model reaction systems have been used for this study: (i) Knoevenagel condensation of 3-nitrobenzaldehyde and malononitrile and (ii) Suzuki coupling of bromobenzene and phenylboronic acid. Using a catalyst in which isolated imprinted amines are surrounded by an acidic silanol-rich environment led to rate accelerations of over 120-fold relative to catalysts in which the amines are surrounded by a hydrophobic environment consisting of trimethylsilyl functional groups for system (i). This result parallels our previous study on the effect of the outer sphere composition on rate acceleration of Knoevenagel reactions using isophthalaldehyde as the aldehyde reactant. We also extended our method for the hydrophilic imprinting of bulk silica to organometallic systems, by successfully synthesizing a tethered palladium complex within the imprinted pocket. This material was used as an active catalyst for (ii). Our results show that a hydrophobic framework environment results in higher initial turnover frequencies than an acidic silanol-rich framework for the Suzuki coupling reaction of bromobenzene and phenylboronic acid, albeit with a lower overall effect than observed in the Knoevenagel system (i). Altogether, these results demonstrate the control of chemical reactivity via the rational design of the outer sphere using an imprinting approach.

Organostannoxane-Supported Palladium Nanoparticles. Highly Efficient Catalysts for Suzuki-Coupling Reactions

2009 ◽  
Vol 28 (20) ◽  
pp. 5883-5888 ◽  
Author(s):  
Vadapalli Chandrasekhar ◽  
Ramakirushnan Suriya Narayanan ◽  
Pakkirisamy Thilagar
Keyword(s):  
Palladium Nanoparticles ◽  
Suzuki Coupling ◽  
Coupling Reactions ◽  
Highly Efficient ◽  
Supported Palladium
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