Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)

2021 ◽  
Vol 9 (9) ◽  
pp. 2233-2239
Author(s):  
Adrià Botet-Carreras ◽  
Cristina Tamames-Tabar ◽  
Fabrice Salles ◽  
Sara Rojas ◽  
Edurne Imbuluzqueta ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Aqueous Solubility ◽  
Carrier System ◽  
System P ◽  
Metal Organic ◽  
Drug Carrier System ◽  
Organic Framework

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.

Mesoporous metal–organic framework MIL-100(Fe) as drug carrier

Adsorption ◽  
2021 ◽  
Author(s):  
Paulo G. M. Mileo ◽  
Diony N. Gomes ◽  
Daniel V. Gonçalves ◽  
Sebastião M. P. Lucena
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
Metal Organic ◽  
Mesoporous Metal ◽  
Organic Framework

Novel photofunctional hybrid materials (alumina and titania) functionalized with both MOF and lanthanide complexes through coordination bonds

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38761-38768 ◽  
Author(s):  
X. Y. Xu ◽  
B. Yan
Keyword(s):  
Hybrid Materials ◽  
Hybrid System ◽  
Lanthanide Complexes ◽  
Metal Organic Framework ◽  
Sol Gel ◽  
System P ◽  
Metal Organic ◽  
Coordination Bonds ◽  
Organic Framework

Multi-component sol–gel derived alumina and titania hybrid materials are assembled by the functionalization of both lanthanide complexes and a special metal organic framework compound: Al-MIL-53-COOH through coordination bonds. Multi-color luminescence and white colored light can be tuned by controlling the different units in the hybrid system.

One-pot synthesis of a metal–organic framework-based drug carrier for intelligent glucose-responsive insulin delivery

2018 ◽  
Vol 54 (42) ◽  
pp. 5377-5380 ◽  
Author(s):  
Yan Duan ◽  
Fanggui Ye ◽  
Yuanlin Huang ◽  
Yuemei Qin ◽  
Caimei He ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
Insulin Delivery ◽  
Glucose Stimulation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Metal Organic ◽  
Organic Framework

A glucose-responsive metal–organic framework (MOF)-based insulin delivery nanosystem was developed via a one-pot process. The system relies on the MOF response to glucose stimulation and this can promote insulin delivery.

scholarly journals In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1211 ◽  
Author(s):  
Gongsen Chen ◽  
Xin Leng ◽  
Juyuan Luo ◽  
Longtai You ◽  
Changhai Qu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Carrier ◽  
In Vitro Cytotoxicity ◽  
In Vitro Toxicity ◽  
Porous Iron ◽  
Dapi Staining ◽  
Toxicological Assessment ◽  
Metal Organic ◽  
Organic Framework

A MIL series metal‒organic framework (MOF), MIL-100(Fe), was successfully synthesized at the nanoscale and fully characterized by TEM, TGA, XRD, FTIR, DLS, and BET. A toxicological assessment was performed using two different cell lines: human normal liver cells (HL-7702) and hepatocellular carcinoma (HepG2). In vitro cytotoxicity of MIL-100(Fe) was evaluated by the MTT assay, LDH releasing rate assay, DAPI staining, and annexin V/PI double staining assay. The safe dose of MIL-100(Fe) was 80 μg/mL. It exhibited good biocompatibility, low cytotoxicity, and high cell survival rate (HL-7702 cells’ viability >85.97%, HepG2 cells’ viability >91.20%). Therefore, MIL-100(Fe) has a potential application as a drug carrier.

The highly efficient elimination of intracellular bacteria via a metal organic framework (MOF)-based three-in-one delivery system

Nanoscale ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 9468-9477 ◽  
Author(s):  
Xu Zhang ◽  
Lizhi Liu ◽  
Lunjie Huang ◽  
Wentao Zhang ◽  
Rong Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Intracellular Bacteria ◽  
Highly Efficient ◽  
System P ◽  
Metal Organic ◽  
Efficient Elimination ◽  
Organic Framework

Highly efficient elimination of intracellular bacteria via a hyaluronic acid-functionalized metal organic framework(MOF)/antibiotic system.

Strategic hierarchical improvement of superprotonic conductivity in a stable metal–organic framework system

2019 ◽  
Vol 7 (43) ◽  
pp. 25165-25171 ◽  
Author(s):  
Xiao-Min Li ◽  
Jiang Liu ◽  
Chen Zhao ◽  
Jia-Lin Zhou ◽  
Ling Zhao ◽  
...  
Keyword(s):  
Proton Conductivity ◽  
Metal Organic Framework ◽  
Efficient Strategy ◽  
System P ◽  
Metal Organic ◽  
Framework System ◽  
Organic Framework

An efficient strategy to hierarchically improve the proton conductivity of MOFs by increasing the number of proton sources and hopping sites has been proposed.

scholarly journals Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3369 ◽  
Author(s):  
Gongsen Chen ◽  
Juyuan Luo ◽  
Mengru Cai ◽  
Liuying Qin ◽  
Yibo Wang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Activity ◽  
Hepg2 Cells ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Drug Loading ◽  
Addition Method ◽  
Direct Addition ◽  
Metal Organic ◽  
Organic Framework

Oridonin (ORI) is a natural active ingredient with strong anticancer activity. But its clinical use is restricted due to its poor water solubility, short half-life, and low bioavailability. The aim of this study is to utilize the metal organic framework material MOF-5 to load ORI in order to improve its release characteristics and bioavailability. Herein, MOF-5 was synthesized by the solvothermal method and direct addition method, and characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TG), Brunauer–Emmett–Teller (BET), and Dynamic Light Scattering (DLS), respectively. MOF-5 prepared by the optimal synthesis method was selected for drug-loading and in vitro release experiments. HepG2 cells were model cells. MTT assay, 4′,6-diamidino-2-phenylindole (DAPI) staining and Annexin V/PI assay were used to detect the biological safety of blank carriers and the anticancer activity of drug-loaded materials. The results showed that nano-MOF-5 prepared by the direct addition method had complete structure, uniform size and good biocompatibility, and was suitable as an ORI carrier. The drug loading of ORI@MOF-5 was 52.86% ± 0.59%. The sustained release effect was reliable, and the cumulative release rate was about 87% in 60 h. ORI@MOF-5 had significant cytotoxicity (IC50:22.99 μg/mL) and apoptosis effect on HepG2 cells. ORI@MOF-5 is hopeful to become a new anticancer sustained release preparation. MOF-5 has significant potential as a drug carrier material.

One-pot preparation of a novel CO-releasing material based on a CO-releasing molecule@metal–organic framework system

2017 ◽  
Vol 53 (49) ◽  
pp. 6581-6584 ◽  
Author(s):  
F. J. Carmona ◽  
S. Rojas ◽  
C. C. Romão ◽  
J. A. R. Navarro ◽  
E. Barea ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
One Pot ◽  
System P ◽  
Metal Organic ◽  
Framework System ◽  
Mesoporous Metal ◽  
Organic Framework

A hierarchical micro-mesoporous metal–organic framework has been used as a platform of a photoactivable CO-prodrug to prepare a novel CO-releasing material.

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