Nanosystem as curative platform for allergic disorders management

2021 ◽  
Author(s):  
Pengsheng Fan ◽  
Mengjie Sun ◽  
Di Qin ◽  
Yuan Congshan ◽  
Xiguang Chen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Avoidance ◽  
Inflammatory Disorders ◽  
Emerging Therapies ◽  
Ige Mediated ◽  
Allergic Disorders

Allergy, IgE-mediated inflammatory disorders involving allergic rhinitis, asthma, conjunctivitis, etc., affects billions of people worldwide. Conventional means of allergy managements include allergen avoidance, pharmacotherapy, emerging therapies, etc. Among them, chemotherapeutant...

scholarly journals Sake Lees Fermented with Lactic Acid Bacteria Prevents Allergic Rhinitis-Like Symptoms and IgE-Mediated Basophil Degranulation

2011 ◽  
Vol 75 (1) ◽  
pp. 140-144 ◽  
Author(s):  
Seiji KAWAMOTO ◽  
Mitsuoki KANEOKE ◽  
Kayo OHKOUCHI ◽  
Yuichi AMANO ◽  
Yuki TAKAOKA ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Ige Mediated

Allergic Rhinitis, Conjunctivitis, and Sinusitis

2018 ◽  
Author(s):  
Robert Naclerio
Keyword(s):  
Allergic Rhinitis ◽  
Inflammatory Response ◽  
Key Words ◽  
Outdoor Exposure ◽  
Immunologic Response ◽  
Dust Mites ◽  
Ige Mediated ◽  
Good For ◽  
Perennial Allergens

Allergic rhinitis is an IgE-mediated inflammatory response in the nose to foreign substances known as allergens. It can be classified as seasonal or perennial, depending on the allergens triggering the reaction. This characterization is good for identifying allergen triggers but is limited because it is based on the duration of outdoor exposure (e.g., grass pollinates for 2 months in Chicago and nearly 11 months in Texas). Also, some perennial allergens, such as dust mites, have seasons. The Allergic Rhinitis in Asthma (ARIA) classification was developed to focus on therapy. It assumes that exposure to perennial and to seasonal allergen leads to the same immunologic response. ARIA places patients into the categories of mild intermittent, mild persistent, moderate/severe intermittent, and moderate/severe persistent to recommend treatment and emphasizes the link between allergic rhinitis and asthma. This review contains 5 figures, 9 tables, and 56 references. Key Words: Sinusitis, infection, allergy, antibiotic, decongestant, antihistamine  

scholarly journals Histamine and its Release from Nasal Polyps: Preliminary Communication

1984 ◽  
Vol 77 (2) ◽  
pp. 120-124 ◽  
Author(s):  
A B Drake-Lee
Keyword(s):  
Extracellular Fluid ◽  
Specific Ige ◽  
Transmission Electron ◽  
Dust Mite ◽  
Polyp Tissue ◽  
Mixed Grass ◽  
Preliminary Communication ◽  
Ige Mediated ◽  
Allergic Disorders

Two hundred consecutive patients admitted for polypectomy had no evidence of an increased incidence of allergic disorders. Mast cell degranulation was found on transmission electron microscopy and this resulted in considerable quantities of histamine in polyp extracellular fluid (124–7300 ng/ml). RAST levels of allergen-specific IgE to house-dust mite and mixed-grass pollens were raised in 4 out of 28 cases in polyp fluid, and in only one matched serum. In vitro challenge of polyp tissue with allergen extract and anti-IgE suggested an IgE-mediated response in only 4 of 36 patients.

scholarly journals Role of innate lymphoid cells in allergic diseases

2019 ◽  
Vol 40 (3) ◽  
pp. 138-145 ◽  
Author(s):  
M. Asghar Pasha ◽  
Gargi Patel ◽  
Russell Hopp ◽  
Qi Yang
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Food Allergies ◽  
Antigen Receptors ◽  
Medline Search ◽  
Allergic Disorders

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

Mast cell stabilizers

1992 ◽  
Vol 107 (6_part_2) ◽  
pp. 841-844 ◽  
Author(s):  
Hueston C. King
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cell ◽  
Cell Membrane ◽  
Nasal Mucosa ◽  
Nasal Polyps ◽  
Nasal Congestion ◽  
Correct Diagnosis ◽  
Vasomotor Rhinitis ◽  
Ige Mediated ◽  
Exercise Induced

The precise mode of action of the well-studied cromolyn sodium and the newer nedocromil sodium has not been completely elucidated. Because the drugs do not pass the cell membrane and enter the cell, they are virtually not metabolized, do not exert a systemic action, and therefore are associated with only minimal systemic toxicity. To be effective either drug must be applied topically and directly to the nasal mucosa. Proper contact with the nasal mucosa is essential for efficacy; in patients with nasal congestion and secretions, vasoconstrictors or saline lavages are indicated before cromolyn or nedocromil use. Both products are highly effective in patients who have IgE-mediated allergic rhinitis but must be administered prophylactically before exposure to an allergen to prevent development of the allergic event. Neither drug is effective in vasomotor rhinitis, exercise-induced rhinitis, or in the management of nasal polyps. Correct diagnosis is essential before therapy.

scholarly journals Increased oxidative stress in allergic rhinitis. Attention; Ruywayda Adams

2021 ◽  
Vol 8 (1) ◽  
pp. 01-02
Author(s):  
Hilary Solomons
Keyword(s):  
Oxidative Stress ◽  
Air Pollution ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Cigarette Smoke ◽  
Environmental Exposure ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Ample Evidence ◽  
Allergic Disorders

There is ample evidence that allergic disorders such as asthma, rhinitis and atopic dermatitis are mediated by oxidative stress. Excessive exposure to reactive oxygen and nitrogen species is the hallmark of oxidative stress and leads to damage of proteins, lipids and DNA. Oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution and cigarette smoke.

scholarly journals Plasma EVs Display Antigen-Presenting Characteristics in Patients With Allergic Rhinitis and Promote Differentiation of Th2 Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Shu-Bin Fang ◽  
Zhi-Rou Zhou ◽  
Ya-Qi Peng ◽  
Xiao-Qing Liu ◽  
Bi-Xin He ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Allergic Rhinitis ◽  
T Cell ◽  
Th2 Cells ◽  
T Cell Proliferation ◽  
Healthy Control ◽  
Ige Mediated ◽  
Der P 1 ◽  
Antigen Presenting ◽  
Intercellular Communications

BackgroundAllergic rhinitis (AR) is characterized by IgE-mediated mucosa response after exposure to allergens. Extracellular vesicles (EVs) are nano-size vesicles containing biological cargos for intercellular communications. However, the role of plasma EVs in pathogenesis of AR remains largely unknown.MethodsPlasma EVs from patients with AR were isolated, quantified, and characterized. The expression of Der p 1 and antigen-presenting molecules on EVs was determined by Western blot, flow cytometry, or ELISA. PKH26- and CFSE (carboxyfluorescein succinimidyl ester)-stained AR-EVs were used to determine the uptake of EVs by CD4+T cells and their effects on CD4+T cell proliferation, respectively.ResultsPlasma EVs in healthy control (HC) and AR patients were similar in the concentration of particles, expression for specific EV markers, and both had structural lipid bilayer. However, the levels of Der p 1 on plasma EVs from both mild and moderate-severe AR patients were significantly higher than that on HC. The levels of antigen-presenting molecules on plasma EVs were similar from three subjects. Moreover, levels of Der p 1 on EVs in plasma, but not nasal secretion, were significantly associated with the symptom score of AR patients and level of plasma IL-13. Additionally, plasma EVs from patients with AR promoted the development of Th2 cells, while no effect was found on CD4+ T-cell proliferation.ConclusionsPlasma EVs derived from patients with AR exhibited antigen-presenting characteristics and promoted differentiation of Th2 cells, thus providing novel understanding of the pathogenesis of AR.

Sign in / Sign up

Export Citation Format

Share Document