A Light-Activated Nanotherapeutic with Broad-Spectrum Bacterial Recognition to Eliminate Drug-Resistant Pathogens

2021 ◽  
Author(s):  
Xiaosong Wei ◽  
Yingchao Gao ◽  
Yuqing Hu ◽  
Yufei Zhang ◽  
Xinge Zhang
Keyword(s):  
Human Health ◽  
Broad Spectrum ◽  
Multidrug Resistant ◽  
Morbidity And Mortality ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Multidrug Resistant Bacteria ◽  
Drug Resistant Bacteria

Obstinate infections caused by drug-resistant bacteria severely threaten human health. And the emergence of multidrug-resistant bacteria increases the morbidity and mortality of patients, innovative or alternative therapeutics thus necessitates the...

scholarly journals Isolation of Multidrug Resistant Bacteria from Aspirates of Cancer Patients

2019 ◽  
Vol 35 (1) ◽  
pp. 61-66
Author(s):  
Sunjukta Ahsan ◽  
Rayhan Mahmud ◽  
Kajal Ahsan ◽  
Shamima Begum
Keyword(s):  
Cancer Patients ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Gram Negative Bacteria ◽  
Drug Resistant ◽  
Multidrug Resistant Bacteria ◽  
Esbl Producer ◽  
Drug Resistant Bacteria ◽  
Treatment Facilities ◽  
Isolated Species

Infections due to Gram-negative bacteria are common affairs in cancer patients during aggressive therapy. The present study characterizedmulti-drug resistant bacteria (MDR) isolated from cancer aspirates collected from patients admitted to the National Cancer Hospital in Dhaka, Bangladesh. A total of 210 aspirate samples were collected from cancer patients. Out of 210 samples Acinetobacter spp.led the list of isolates (8.89%, n=45). Of these species, 50% exhibited resistance to Amoxycillin and Nitrofurantoin, each, 25% exhibited resistant to Cefotaxime, Azithromycin, Ciprofloxacin, Clindamycin, and Sulfamethoxazole. A total of 33.33% of the Bordetella spp.which accounted 6.67%of the total isolates exhibited resistance to Cefotaxime. All oftheLegionellapneumophila,comprising 4.4%of the isolated species, wereresistant to Cefotaxime, Azithromycin, and Clindamycin.In contrast, 50% were resistant to Cefotaxime, Azithromycin, and Ceftriaxone. Of the Escherichia coli(4.4%, n=45) isolated,50% exhibited resistance to Cefotaxime, Clindamycin, Ceftriaxone, Amoxycillinand Sulfamethoxazole.The only isolate of Klebsiella sp. was demonstrated to be an ESBL producer. The isolation of multidrug resistant bacteria from cancer patients is of particular concern in Bangladesh where cancer and drug resistance are both common phenomena but treatment facilities are poor. To our knowledge this is the first report of the isolation of drug resistant bacteria from cancer patients from Dhaka city. Bangladesh J Microbiol, Volume 35 Number 1 June 2018, pp 61-66

Silver nanoflower coupled with low dose antibiotics enables highly effective Drug-resistant bacteria eradication

2021 ◽  
Author(s):  
Xin Li ◽  
Xianting Ding ◽  
Khan Zara Ahmad ◽  
Jie He ◽  
Hongxia Li ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Low Dose ◽  
Multidrug Resistant ◽  
Effective Drug ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Multidrug Resistant Bacteria ◽  
Effective Strategies ◽  
Drug Resistant Bacteria ◽  
Highly Effective

Due to the global overuse of antibiotics, multidrug-resistant bacteria (MDR) continuously call for effective strategies to tackle the antibiotic resistance crisis. Here, we develop a silver nanomaterial with a petal-like...

scholarly journals Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections

2021 ◽  
Author(s):  
Yingxue Deng ◽  
Rui Huang ◽  
Songyin Huang ◽  
Menghua Xiong
Keyword(s):  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Antimicrobial Properties ◽  
Therapeutic Index ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Efficient Delivery ◽  
Delivery Vehicles

Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drugresistance. However, their therapeutic efficacy in vivo, especially for infections in deep organs, is limited owing to their systemic toxicity and low bioavailability. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Herein, we will discuss the current progress of using nanoparticles as delivery vehicles for AMPs for the treatment of deep infections.

Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis

2020 ◽  
Vol 8 (18) ◽  
pp. 4975-4996
Author(s):  
Pengfei Zou ◽  
Wen-Ting Chen ◽  
Tongyi Sun ◽  
Yuanyuan Gao ◽  
Li-Li Li ◽  
...  
Keyword(s):  
Human Health ◽  
Antimicrobial Therapy ◽  
Bacterial Infections ◽  
The Body ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Self Assembling ◽  
Recent Advances ◽  
Drug Resistant Bacteria ◽  
Therapy And Diagnosis

Bacterial infections, especially the refractory treatment of drug-resistant bacteria, are one of the greatest threats to human health. Self-assembling peptide-based strategies can specifically detect the bacteria at the site of infection in the body and kill it.

scholarly journals Multidrug-Resistant Bacteria with ESBL Genes: A Growing Threat Among HIV Patients in Nepal

2021 ◽  
Author(s):  
Riju Maharjan ◽  
Anup Bastola ◽  
Nabaraj Adhikari ◽  
Komal Raj Rijal ◽  
Megha Raj Banjara ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Morbidity And Mortality ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Bacterial Isolates ◽  
Multidrug Resistant Bacteria ◽  
Hiv Patients ◽  
Microbiological Methods ◽  
Tract Infections ◽  
Esbl Producers

Abstract Background Bacterial opportunistic infections are quite common in HIV patients. Besides HIV-TB coinfection, lower respiratory tract infections by multidrug-resistant bacteria cause significant morbidity and mortality among HIV patients. This study was done to evaluate the bacterial coinfection of LRT and detect plasmid-mediated blaTEM and blaCTX−M genes among Extended-Spectrum β-Lactamase (ESBL) producing isolates from sputum samples in HIV patients. Methods A total of 263 sputum samples from HIV-positive cases were processed with standard microbiological methods to isolate and identify the possible pathogens. The identified bacterial isolates were assessed for antibiotic susceptibility pattern by using modified Kirby Bauer disk diffusion method following Clinical Laboratory Standard Institute (CLSI) guidelines. Plasmid DNA was extracted from multidrug-resistant and ESBL producers for screening of ESBL genes; blaCTX−M and blaTEM by conventional PCR method using specific primers. Results Of 263 sputum samples, 67 (25.48%) were culture positive showing Klebsiella pneumoniae; 17(25.37%) as the most predominant one. A higher rate of infection (4/8, 50%) was observed among old-aged people of 61 -70 years, whereas no infection was observed below 20 years. About 30.0% (15/50) of smokers, 32.86% (23/70) cases with previous pulmonary tuberculosis and 52.38% (11/21) with CD4 count <200 cells/µl were found to be susceptible to LRTIs. Among 53 bacterial isolates, 52.83% (n=28) were multidrug-resistant and 43.4% (n=23) were ESBL producers. All ESBL producers were sensitive to Colistin and Polymyxin B. Of 23 ESBL producers, 47.83% (11/23) and 8.6% (2/23) possessed only blaCTX−M and blaTEM genes respectively and 43.48% (10/23) possessed both ESBL genes. Conclusion The increasing rate of MDR bacterial infections mainly ESBL producers of LRTIs causes difficulty in the management of diseases leading to high morbidity and mortality of HIV patients.

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