Growth factors regional patterned and photoimmobilized scaffold applied to bone tissue regeneration

2020 ◽  
Vol 8 (48) ◽  
pp. 10990-11000
Author(s):  
Ling-Kun Zhang ◽  
Wu-Ya Chen ◽  
Hui-Min Wang ◽  
Chao Liu ◽  
Jiecheng He ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Hybrid Scaffolds

Growth factors immobilized on poly-hybrid scaffolds induced orderly BMSC differentiation for bone tissue regeneration.

scholarly journals Enhanced Cells Anchoring to Electrospun Hybrid Scaffolds With PHBV and HA Particles for Bone Tissue Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Joanna E. Karbowniczek ◽  
Łukasz Kaniuk ◽  
Krzysztof Berniak ◽  
Adam Gruszczyński ◽  
Urszula Stachewicz
Keyword(s):  
Cell Proliferation ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Focused Ion Beam ◽  
Ion Beam ◽  
Inorganic Compounds ◽  
Bone Tissue Regeneration ◽  
Sem Imaging ◽  
Hybrid Scaffolds

Hybrid materials combining organic and inorganic compounds used as scaffolds are highly beneficial in bone regeneration. In this study, we successfully produced by blend electrospinning poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) scaffolds enriched with hydroxyapatite (HA) particles to biomimic bone tissue for improved and faster regeneration processes. The morphology, fiber diameters, and composition of the scaffolds were investigated by scanning electron microscopy (SEM) techniques followed by focused ion beam (FIB) sectioning to verify HA particles integration with PHBV fibers. In vitro cell culture was performed for 7 days and followed with the cell proliferation test (CellTiter-Blue® Assay). Additionally, cell integration with the scaffold was visualized by confocal and SEM imaging. We developed a simple way of obtaining hybrid scaffolds by electrospinning PHBV solution with HA particles without any post-processing. The PHBV + HA scaffold enhanced cell proliferation and filopodia formation responsible for cell anchoring within the created 3D environment. The obtained results show the great potential in the development of hybrid scaffolds stimulating bone tissue regeneration.

3D printed micro-chambers carrying stem cell spheroids and pro-proliferative growth factors for bone tissue regeneration

2020 ◽  
Vol 13 (1) ◽  
pp. 015011
Author(s):  
Jinkyu Lee ◽  
Ji Min Seok ◽  
Seung Jae Huh ◽  
Hayeon Byun ◽  
Sangmin Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Cell Spheroids ◽  
Proliferative Growth ◽  
3D Printed

Ribose mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies

2017 ◽  
Vol 77 ◽  
pp. 594-605 ◽  
Author(s):  
Gopal Shankar Krishnakumar ◽  
Natalia Gostynska ◽  
Elisabetta Campodoni ◽  
Massimiliano Dapporto ◽  
Monica Montesi ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Hybrid Scaffolds
Sign in / Sign up

Export Citation Format

Share Document