Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application

2020 ◽  
Vol 8 (43) ◽  
pp. 9980-9996
Author(s):  
Alessandro Jäger ◽  
Ricardo K. Donato ◽  
Magdalena Perchacz ◽  
Katarzyna Z. Donato ◽  
Zdeněk Starý ◽  
...  
Keyword(s):  
Human Metabolite

In a set of experiments, we demonstrated that the combination of alkyl succinates and dilinoleic acid-based monomers produces biocompatible polyesters outperforming, biologically and mechanically, polymers used for bioapplications such as PVC, PLGA and PCL.

Determination of riociguat and its major human metabolite M-1 in human plasma by stable-isotope dilution LCMS/MS

Bioanalysis ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 193-205 ◽  
Author(s):  
Mark-Jean Gnoth ◽  
Peter-Michael Hopfe ◽  
Waldemar Czembor
Keyword(s):  
Stable Isotope ◽  
Human Plasma ◽  
Isotope Dilution ◽  
Human Metabolite ◽  
Stable Isotope Dilution

Recent advances in biotransformation by Cunninghamella species

2021 ◽  
Vol 22 ◽  
Author(s):  
Manoela Daiele Gonçalves ◽  
Fernanda Tomiotto-Pellissier ◽  
Ricardo Luís Nascimento de Matos ◽  
João Paulo Assolini ◽  
Bruna Taciane da Silva Bortoleti ◽  
...  
Keyword(s):  
Phase I ◽  
Filamentous Fungi ◽  
Bioactive Compounds ◽  
Structural Changes ◽  
Chemical Compounds ◽  
Active Compounds ◽  
Human Metabolite ◽  
Biotransformation Process ◽  
Phase I And Ii ◽  
Synthetic Origin

: The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.

Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans

2010 ◽  
Vol 75 (12) ◽  
pp. 1229-1247 ◽  
Author(s):  
Karel Naiman ◽  
Petr Hodek ◽  
Jiří Liberda ◽  
Heinz H. Schmeiser ◽  
Eva Frei ◽  
...  
Keyword(s):  
Rat Liver ◽  
Dna Adducts ◽  
Cytochromes P450 ◽  
Environmental Pollutant ◽  
Microsomal Metabolism ◽  
Human Metabolite ◽  
Hepatic Microsomes

o-Aminophenol and N-(2-methoxyphenyl)hydroxylamine are human metabolites of the industrial and environmental pollutant and bladder carcinogen 2-methoxyaniline (o-anisidine). The latter one is also a human metabolite of another pollutant and bladder carcinogen, 2-methoxynitrobenzene (o-nitroanisole). Here, we investigated the ability of rat hepatic micro- somes to metabolize these metabolites. N-(2-methoxyphenyl)hydroxylamine is metabolized by rat hepatic microsomes to o-aminophenol and predominantly o-anisidine, the parent carcinogen from which N-(2-methoxyphenyl)hydroxylamine is formed. In addition, two N-(2-methoxyphenyl)hydroxylamine metabolites, whose exact structures have not been identified as yet, were generated. On the contrary, no metabolites were found to be formed from o-aminophenol by rat hepatic microsomes. Whereas N-(2-methoxyphenyl)hydroxylamine is responsible for formation of three deoxyguanosine adducts in DNA, o-aminophenol seems to be a detoxication metabolite of N-(2-methoxyphenyl)hydroxylamine and/or a parental carcinogen, o-anisidine; no o-aminophenol-derived DNA adducts were found after its reaction with microsomal cytochromes P450 and peroxidases.

The postantibiotic effect of clarithromycin and its major human metabolite, 14-hydroxyclarithromycin

1993 ◽  
Vol 32 (3) ◽  
pp. 507-509 ◽  
Author(s):  
F. SCAGLIONE ◽  
S. DUGNANI ◽  
G. DEMARTINI ◽  
M. SAUDELLI ◽  
G. GALMOZZI ◽  
...  
Keyword(s):  
Postantibiotic Effect ◽  
Human Metabolite

Review of the Metabolism and Mode of Action of Cyclophosphamide

1976 ◽  
Vol 59 (5) ◽  
pp. 1028-1036 ◽  
Author(s):  
Catherine Fenselau
Keyword(s):  
Mass Spectrometry ◽  
Active Compound ◽  
Mode Of Action ◽  
Assay Method ◽  
Human Metabolite ◽  
Phosphoramide Mustard ◽  
Aziridinium Ion

Abstract A review of recent studies of the pharmacology of cyclophosphamide is presented. Particular attention is paid to the use of mass spectrometry in the identification of the active compound phosphoramide mustard as a circulating human metabolite of cyclophosphamide, the development of an assay method for cyclophosphamide, phosphoramide mustard, and nornitrogen mustard, and a demonstration that alkylation by phosphoramide mustard proceeds through a symmetrical aziridinium ion.

Syntheses of a radiolabelled CXCR2 antagonist AZD5069 and its major human metabolite

2016 ◽  
Vol 59 (11) ◽  
pp. 432-438 ◽  
Author(s):  
Michael J. Hickey ◽  
Paul H. Allen ◽  
Moya Caffrey ◽  
Peter Hansen ◽  
Lee P. Kingston ◽  
...  
Keyword(s):  
Human Metabolite ◽  
Cxcr2 Antagonist
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