Cell-penetrating peptide-conjugated lipid/polymer hybrid nanovesicles for endoplasmic reticulum-targeting intracellular delivery

2021 ◽  
Author(s):  
Jeong Yi Kang ◽  
Seulgi Kim ◽  
Juhyeon Kim ◽  
Nae-Gyu Kang ◽  
Chul-Su Yang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Polymer Hybrid ◽  
Cell Penetrating ◽  
Er Targeting ◽  
Endoplasmic Reticulum Targeting ◽  
Delivery Approach

An ER-targeting, intracellular delivery approach that utilizes cell-penetrating peptide-conjugated lipid/polymer hybrid nanovehicles is proposed.

Porous Silicon–Cell Penetrating Peptide Hybrid Nanocarrier for Intracellular Delivery of Oligonucleotides

2013 ◽  
Vol 11 (2) ◽  
pp. 382-390 ◽  
Author(s):  
Jussi Rytkönen ◽  
Piret Arukuusk ◽  
Wujun Xu ◽  
Kaido Kurrikoff ◽  
Ülo Langel ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Silicon Cell

scholarly journals Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release

Nanoscale ◽  
2018 ◽  
Vol 10 (43) ◽  
pp. 20366-20376 ◽  
Author(s):  
Elnaz Yaghini ◽  
Ruggero Dondi ◽  
Karen J. Edler ◽  
Marilena Loizidou ◽  
Alexander J. MacRobert ◽  
...  
Keyword(s):  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Protein Toxin ◽  
Cell Penetrating ◽  
A Cell ◽  
Novel Strategy

Light-triggered intracellular delivery of a protein toxin was achieved by codelivery via a liposomal nanocarrier, targeted with a cell-penetrating peptide (CPP)–photosensitiser conjugate.

scholarly journals Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+

2019 ◽  
Vol 10 (47) ◽  
pp. 10881-10887 ◽  
Author(s):  
Le Fang ◽  
Giuseppe Trigiante ◽  
Rachel Crespo-Otero ◽  
Chris S. Hawes ◽  
Michael P. Philpott ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Fluorescent Probes ◽  
Biological Processes ◽  
Er Targeting ◽  
Endoplasmic Reticulum Targeting

Two endoplasmic reticulum (ER) targeting probes were developed to image mobile Zn2+ to help understand Zn2+ related biological processes in the ER.

scholarly journals Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

2010 ◽  
Vol 190 (4) ◽  
pp. 511-521 ◽  
Author(s):  
Kohichi Matsunaga ◽  
Eiji Morita ◽  
Tatsuya Saitoh ◽  
Shizuo Akira ◽  
Nicholas T. Ktistakis ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Mammalian Cells ◽  
Embryonic Stem ◽  
Pi3 Kinase ◽  
Class Iii ◽  
Autophagosome Formation ◽  
Membranous Structure ◽  
Er Targeting ◽  
Endoplasmic Reticulum Targeting ◽  
Phosphatidylinositol 3

Autophagy is a catabolic process that allows cells to digest their cytoplasmic constituents via autophagosome formation and lysosomal degradation. Recently, an autophagy-specific phosphatidylinositol 3-kinase (PI3-kinase) complex, consisting of hVps34, hVps15, Beclin-1, and Atg14L, has been identified in mammalian cells. Atg14L is specific to this autophagy complex and localizes to the endoplasmic reticulum (ER). Knockdown of Atg14L leads to the disappearance of the DFCP1-positive omegasome, which is a membranous structure closely associated with both the autophagosome and the ER. A point mutation in Atg14L resulting in defective ER localization was also defective in the induction of autophagy. The addition of the ER-targeting motif of DFCP1 to this mutant fully complemented the autophagic defect in Atg14L knockout embryonic stem cells. Thus, Atg14L recruits a subset of class III PI3-kinase to the ER, where otherwise phosphatidylinositol 3-phosphate (PI3P) is essentially absent. The Atg14L-dependent appearance of PI3P in the ER makes this organelle the platform for autophagosome formation.

scholarly journals Cell-Penetrating Peptide-Functionized Quantum Dots for Intracellular Delivery

2010 ◽  
Vol 10 (12) ◽  
pp. 7897-7905 ◽  
Author(s):  
Betty R. Liu ◽  
Yue-Wern Huang ◽  
Huey-Jenn Chiang ◽  
Han-Jung Lee
Keyword(s):  
Quantum Dots ◽  
Intracellular Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin

2015 ◽  
Vol 51 (12) ◽  
pp. 2421-2424 ◽  
Author(s):  
Hiroaki Kitagishi ◽  
Fumihiko Chai ◽  
Shigeru Negi ◽  
Yukio Sugiura ◽  
Koji Kano
Keyword(s):  
Efficient Method ◽  
Intracellular Delivery ◽  
Water Soluble ◽  
Cell Penetrating Peptide ◽  
Supramolecular Interaction ◽  
Cell Penetrating ◽  
A Cell

A convenient and efficient method for intracellular delivery of a water-soluble anionic porphyrin has been developed by utilizing its supramolecular interaction with per-O-methyl-β-cyclodextrin bearing an octaarginine chain as a cell-penetrating peptide.

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