The crown ether size and stereochemistry affect the self-assembly, hydrogelation, and cellular interactions of crown ether/peptide conjugates

2020 ◽  
Vol 8 (43) ◽  
pp. 9961-9970
Author(s):  
Abdelreheem Abdelfatah Saddik ◽  
Mohiuddin Mohammed ◽  
Hsin-Chieh Lin
Keyword(s):  
Cell Adhesion ◽  
Crown Ether ◽  
Self Assembly ◽  
The Self ◽  
Ring Size ◽  
Cellular Interactions ◽  
Peptide Conjugates ◽  
Nanofiber Morphology ◽  
Cell Adhesion And Proliferation

Crown ether ring size affects nanofiber morphology of hydrogels upon conjugation with D- and L-phenylalanine dipeptides. Random nanofibers showed enhanced cell adhesion and proliferation whereas twisted nanofibers displayed weak cell attachments.

scholarly journals Tuning the self-assembly of a ditopic crown ether functionalized oligo(p-phenylenevinylene)

2007 ◽  
Vol 17 (25) ◽  
pp. 2654 ◽  
Author(s):  
Pim G. A. Janssen ◽  
Pascal Jonkheijm ◽  
Pall Thordarson ◽  
Jeroen C. Gielen ◽  
Peter C. M. Christianen ◽  
...  
Keyword(s):  
Crown Ether ◽  
Self Assembly ◽  
The Self

Shear-induced slippage of the self-assembly of crown ether-centered two-armed copolymers

2005 ◽  
Vol 252 (4) ◽  
pp. 1132-1138 ◽  
Author(s):  
Jun Fu ◽  
Yang Cong ◽  
Xiang Yu ◽  
Jian Li ◽  
Caiyuan Pan ◽  
...  
Keyword(s):  
Crown Ether ◽  
Self Assembly ◽  
The Self

Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

2018 ◽  
Vol 54 (4) ◽  
pp. 401-404 ◽  
Author(s):  
R. Otter ◽  
K. Klinker ◽  
D. Spitzer ◽  
M. Schinnerer ◽  
M. Barz ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular Assembly ◽  
The Self ◽  
Core Shell ◽  
Ph Responsive ◽  
Peptide Conjugates ◽  
Β Sheets

ABA′ triblock peptide–polysarcosine–peptide conjugates fold into antiparallel β-sheets, which promotes the self-assembly into polysarcosine-shielded core–shell nanorods with protein repellent properties.

scholarly journals Enzyme assisted peptide self-assemblies trigger cell adhesion in high density oxime based host gels

2020 ◽  
Vol 8 (20) ◽  
pp. 4419-4427 ◽  
Author(s):  
Miryam Criado-Gonzalez ◽  
Breyinn Loftin ◽  
Jennifer Rodon Fores ◽  
Dominique Vautier ◽  
Leyla Kocgozlu ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Future Development ◽  
Self Assembly ◽  
High Density ◽  
The Self ◽  
The Future ◽  
Assembly Behavior

Studying the influence of hydrogel matrices on the self-assembly behavior of peptides and interaction with cells guides the future development of engineered biomaterials.

Doxorubicin-reinforced supramolecular hydrogels of RGD-derived peptide conjugates for pH-responsive drug delivery

2019 ◽  
Vol 17 (15) ◽  
pp. 3853-3860 ◽  
Author(s):  
Leixia Mei ◽  
Keming Xu ◽  
Ziran Zhai ◽  
Suyun He ◽  
Tingting Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
The Self ◽  
Ph Responsive ◽  
Peptide Conjugates

Doxorubicin reinforced the self-assembly of RGD-derived peptide conjugates responsive to mild acidity.

scholarly journals Morphological transformation enhances Tumor Retention by Regulating the Self-assembly of Doxorubicin-peptide Conjugates

Theranostics ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 8162-8178
Author(s):  
Liu Xu ◽  
Yutong Wang ◽  
Chenqi Zhu ◽  
Shujing Ren ◽  
Yurou Shao ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Morphological Transformation ◽  
Peptide Conjugates ◽  
Tumor Retention

Study on the self-assembly behaviors based on aromatic carboxylic acids and dibenzo-diaza-crown ether salts

2020 ◽  
Vol 1219 ◽  
pp. 128587
Author(s):  
Wei Wang ◽  
Zhuoyu Li ◽  
Rong Zeng ◽  
Chunqiang Yang ◽  
Lingbo Ji ◽  
...  
Keyword(s):  
Crown Ether ◽  
Carboxylic Acids ◽  
Self Assembly ◽  
The Self ◽  
Aromatic Carboxylic Acids

scholarly journals Tuning dynamic DNA- and peptide-driven self-assembly in DNA-peptide conjugates

2021 ◽  
Author(s):  
Emerald Taylor ◽  
Akiko Sato ◽  
Prashant Gudeangadi ◽  
David Beal ◽  
James Hopper ◽  
...  
Keyword(s):  
Self Assembly ◽  
Time Course ◽  
Chemical Diversity ◽  
The Self ◽  
Peptide Conjugates ◽  
Peptide Assembly ◽  
Aging Studies ◽  
Aging Study ◽  
High Level ◽  
Single Macromolecule

DNA-peptide conjugates offer an opportunity to marry the benefits of both biomolecules, such as the high level of control and programmability found with DNA and the chemical diversity and biological stability of peptides. These hybrid systems offer great potential in fields such as therapeutics, nanotechnology, and robotics to name a few. Using the first DNA-β-turn peptide conjugate, we present three studies designed to investigate the self-assembly of DNA-peptide conjugates over a period of 28 days. Time-course studies, such as these have not been previously conducted for DNA-peptide conjugates, although they are common in pure peptide assembly, for example in amyloid research. By using aging studies to assess the structures produced, we gain insights into the dynamic nature of these systems. The first study explores the influence varying amounts of DNA-peptide conjugates have on the self-assembly of our parent peptide. Study 2 explores how DNA and peptide can work together to change the structures observed during aging. Study 3 investigates the presence of orthogonality within our system by switching the DNA and peptide control on and off independently. These results show that two orthogonal self-assemblies can be combined and operated either independently or in tandem within a single macromolecule, with both spatial and temporal effects upon the resultant nanostructures.

scholarly journals Tuning dynamic DNA- and peptide-driven self-assembly in DNA-peptide conjugates

2021 ◽  
Author(s):  
Emerald Taylor ◽  
Akiko Sato ◽  
Prashant Gudeangadi ◽  
David Beal ◽  
James Hopper ◽  
...  
Keyword(s):  
Self Assembly ◽  
Time Course ◽  
Chemical Diversity ◽  
The Self ◽  
Peptide Conjugates ◽  
Peptide Assembly ◽  
Aging Studies ◽  
Aging Study ◽  
High Level ◽  
Single Macromolecule

DNA-peptide conjugates offer an opportunity to marry the benefits of both biomolecules, such as the high level of control and programmability found with DNA and the chemical diversity and biological stability of peptides. These hybrid systems offer great potential in fields such as therapeutics, nanotechnology, and robotics to name a few. Using the first DNA-β-turn peptide conjugate, we present three studies designed to investigate the self-assembly of DNA-peptide conjugates over a period of 28 days. Time-course studies, such as these have not been previously conducted for DNA-peptide conjugates, although they are common in pure peptide assembly, for example in amyloid research. By using aging studies to assess the structures produced, we gain insights into the dynamic nature of these systems. The first study explores the influence varying amounts of DNA-peptide conjugates have on the self-assembly of our parent peptide. Study 2 explores how DNA and peptide can work together to change the structures observed during aging. Study 3 investigates the presence of orthogonality within our system by switching the DNA and peptide control on and off independently. These results show that two orthogonal self-assemblies can be combined and operated either independently or in tandem within a single macromolecule, with both spatial and temporal effects upon the resultant nanostructures.

Sign in / Sign up

Export Citation Format

Share Document