Reversible antibiotic loading and pH-responsive release from polymer brushes on contact lenses for therapy and prevention of corneal infections

2020 ◽  
Vol 8 (44) ◽  
pp. 10087-10092
Author(s):  
Yishun Guo ◽  
Siyuan Qian ◽  
Lu Wang ◽  
Jiahong Zeng ◽  
Renjie Miao ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Vision Loss ◽  
Contact Lenses ◽  
Ph Responsive ◽  
Corneal Infection ◽  
Corneal Damage

Corneal infection is an important cause of corneal damage and vision loss.

Contact lens-related keratitis

2013 ◽  
Vol 154 (45) ◽  
pp. 1781-1789 ◽  
Author(s):  
Zita Steiber ◽  
András Berta ◽  
László Módis
Keyword(s):  
Visual Acuity ◽  
Contact Lens ◽  
Contact Lenses ◽  
Accurate Diagnosis ◽  
Patient History ◽  
Corneal Infection ◽  
Corneal Inflammation ◽  
Corneal Damage ◽  
Targeted Drug ◽  
Healthy Eyes

Nowadays, keratitis, corneal infection due to wearing contact lens means an increasingly serious problem. Neglected cases may lead to corneal damage that can cause blindness in cases of otherwise healthy eyes. Early diagnosis based on the clinical picture and the typical patient history is an important way of prevention. Prophylaxis is substantial to avoid bacterial and viral infection that is highly essential in this group of diseases. Teaching contact lens wearers the proper contact lens care, storage, sterility, and hygiene regulations is of great importance. In case of corneal inflammation early accurate diagnosis supported by microbiological culture from contact lenses, storage boxes or cornea is very useful. Thereafter, targeted drug therapy or in therapy-resistant cases surgical treatment may even be necessary in order to sustain suitable visual acuity. Orv. Hetil., 154(45), 1781–1789.

Pickering emulsions stabilized by palygorskite particles grafted with pH-responsive polymer brushes

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9416-9424 ◽  
Author(s):  
Jia Lu ◽  
Wei Zhou ◽  
Jing Chen ◽  
Yeling Jin ◽  
Keisha B. Walters ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Pickering Emulsions ◽  
Ph Responsive ◽  
Responsive Polymer

The reversibility of emulsions stabilized by PAL–PDEAEMA particles switched by pH can last at least seven successive cycles.

scholarly journals Facile Formation of Highly Mobile Supported Lipid Bilayers on Surface-Quaternized pH-Responsive Polymer Brushes

2015 ◽  
Vol 48 (9) ◽  
pp. 3095-3103 ◽  
Author(s):  
N. Cheng ◽  
P. Bao ◽  
S. D. Evans ◽  
G. J. Leggett ◽  
S. P. Armes
Keyword(s):  
Lipid Bilayers ◽  
Polymer Brushes ◽  
Supported Lipid Bilayers ◽  
Ph Responsive ◽  
Responsive Polymer

scholarly journals Eye Problem and Guidelines for the Prevention of Eye Problems for Students in the Gross Anatomy Laboratory Class

2020 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Occupational Medicine ◽  
Vision Loss ◽  
Contact Lenses ◽  
Health Effect ◽  
Gross Anatomy ◽  
Cross Sectional ◽  
Eye Problems ◽  
Depth Interview ◽  
Anatomy Laboratory ◽  
Sectional Analysis

Context: Formaldehyde is a poisonous substance that can cause many health risks. Objective: To evaluate eye issues and generate guideline for participants working in the anatomy laboratory to avoid eye issues. Methods: Analyzed eye problem from the participants in this cross-sectional analysis study 97 students working in the anatomy laboratory at Burapha University. In-depth interview consisted of 1 administer of Faculty of Medicine, 1 administer of Allied Health Sciences, 2 Teachers, 2 Ophthalmologists, 1 Occupational Medicine and 5 students practicing in the anatomy. This research tool is divided into 3 types: questionnaire, interview and form of evaluation of the severity of health with descriptive statistics. Results: Most of them were 72.04 percent woman. Problems with the eyes include burning sensation 46.23 percent, eye irritation 43.01 percent, eye pain 25.81 percent, epiphora 24.73 percent and vision loss 15.05 percent. Assessment of severity of health impacts It was discovered that there was no effect at 55.91 percent with a slight impact of 44.09 percent, according to occupational medicine principles. Guidelines for anatomy-class students; placed in operating glasses, do not use contact lenses, do not stay long in the laboratory and be careful to touch formaldehyde immediately. Conclusion: It was discovered from this studies that from the real anatomical action there was an issue with the eye, but the issue was at a low level of health effect. As a consequence of this issue, guidelines have been created for protecting the eyes in the anatomy class. The guidelines for the prevention of eye issues resulting from this study are based on the assessment of occupational diseases and expert opinion, which is complete in comparison with previous studies. This strategy can therefore serve as a model for the avoidance of both eye diseases and other illnesses.

scholarly journals Simulating Macular Degeneration to Investigate Activities of Daily Living: A Systematic Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Anne Macnamara ◽  
Celia Chen ◽  
Victor R. Schinazi ◽  
Dimitrios Saredakis ◽  
Tobias Loetscher
Keyword(s):  
Activities Of Daily Living ◽  
Macular Degeneration ◽  
Daily Living ◽  
Vision Loss ◽  
Contact Lenses ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Simulation Methods ◽  
Advantages And Disadvantages ◽  
Age Related

Purpose: Investigating difficulties during activities of daily living is a fundamental first step for the development of vision-related intervention and rehabilitation strategies. One way to do this is through visual impairment simulations. The aim of this review is to synthesize and assess the types of simulation methods that have been used to simulate age-related macular degeneration (AMD) in normally sighted participants, during activities of daily living (e.g., reading, cleaning, and cooking).Methods: We conducted a systematic literature search in five databases and a critical analysis of the advantages and disadvantages of various AMD simulation methods (following PRISMA guidelines). The review focuses on the suitability of each method for investigating activities of daily living, an assessment of clinical validation procedures, and an evaluation of the adaptation periods for participants.Results: Nineteen studies met the criteria for inclusion. Contact lenses, computer manipulations, gaze contingent displays, and simulation glasses were the main forms of AMD simulation identified. The use of validation and adaptation procedures were reported in approximately two-thirds and half of studies, respectively.Conclusions: Synthesis of the methodology demonstrated that the choice of simulation has been, and should continue to be, guided by the nature of the study. While simulations may never completely replicate vision loss experienced during AMD, consistency in simulation methodology is critical for generating realistic behavioral responses under vision impairment simulation and limiting the influence of confounding factors. Researchers could also come to a consensus regarding the length and form of adaptation by exploring what is an adequate amount of time and type of training required to acclimatize participants to vision impairment simulations.

scholarly journals A Review on Management of Amblyopia

2021 ◽  
pp. 211-217
Author(s):  
Khushboo Kolhe ◽  
Sachin Diaghvane
Keyword(s):  
Visual Cortex ◽  
Vision Loss ◽  
Contact Lenses ◽  
Abnormal Development ◽  
Neutral Density Filter ◽  
Visual Axis ◽  
Internet Resources ◽  
Clear Vision ◽  
Density Filter ◽  
Lazy Eye

Amblyopia is a visual cortex neurodevelopmental condition cause am vision abnormalities during childhood. It is one of the most typical causes of vision loss at an early age. It occurs due to abnormal development of the visual cortex. The part receiving signals from the diseased eye does not receive it correctly and thus develops abnormally. This abnormal development during the critical period of growth of child results in brain damage. Depending on its aetiology the  types of amblyopia are Strabismic amblyopia, Visual deprivation amblyopia, Anisometric, Ametropic, Meridional, Toxic amblyopia. Clinical features are visual acuity is reduced, the effect of neutral density filter, the Crowding phenomenon is present. Complications of amblyopia include a Lazy eye becoming weak permanently, the eye may move out from the visual axis (squints). When treating amblyopia, our goal is that the eyes will work together in unison at an equal level; this will create a clear vision in the lazy eye. Amblyopia is treated in various ways depending on the seriousness of the disease and the patient's age. Patching of the non-amblyopic eye, as well as treatment with drugs like atropine, are common treatments. Vision therapy and some modifications to spectacles and contact lenses have been discovered to be effective in treating amblyopia in recent years. Modern Treatment- Falling Blocks, Occlu-pad. With current breakthroughs in amblyopia therapy, the success rate of a multimodal strategy is also improving. The purpose of this review article is to present information on the management of amblyopia. Literature on AMBLYOPIA MANAGEMENT has been taken from PubMed, Scopus, Science Direct, and other internet resources.

Bidimensional Response Maps of Adaptive Thermo- and pH-Responsive Polymer Brushes

2010 ◽  
Vol 43 (18) ◽  
pp. 7744-7751 ◽  
Author(s):  
Xavier Laloyaux ◽  
Bertrand Mathy ◽  
Bernard Nysten ◽  
Alain M. Jonas
Keyword(s):  
Polymer Brushes ◽  
Ph Responsive ◽  
Responsive Polymer

scholarly journals Synthesis of pH-responsive tertiary amine methacrylate polymer brushes and their response to acidic vapour

2011 ◽  
Vol 21 (32) ◽  
pp. 11773 ◽  
Author(s):  
Lee A. Fielding ◽  
Steve Edmondson ◽  
Steven P. Armes
Keyword(s):  
Tertiary Amine ◽  
Polymer Brushes ◽  
Ph Responsive

scholarly journals ON/OFF switching of silicon wafer electrochemistry by pH-responsive polymer brushes

2016 ◽  
Vol 4 (26) ◽  
pp. 6287-6294 ◽  
Author(s):  
G. Panzarasa ◽  
M. Dübner ◽  
V. Pifferi ◽  
G. Soliveri ◽  
C. Padeste
Keyword(s):  
Silicon Wafer ◽  
Methacrylic Acid ◽  
Polymer Brushes ◽  
Ph Responsive ◽  
Controlled Switching ◽  
Responsive Polymer ◽  
Grafting From ◽  
Hybrid Devices ◽  
Ph Controlled

Grafting-from of poly(methacrylic acid) brushes enables pH-controlled switching of silicon wafer electrochemistry, making possible the design of new electrochemical hybrid devices.

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