Biphasic ceramic biomaterials with tunable spatiotemporal evolution for highly efficient alveolar bone repair

2020 ◽  
Vol 8 (35) ◽  
pp. 8037-8049
Author(s):  
Lihong Lei ◽  
Jiayin Han ◽  
Jiahui Wen ◽  
Yuanyuan Yu ◽  
Ting Ke ◽  
...  
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Spatiotemporal Evolution ◽  
Ion Release ◽  
Channel Evolution ◽  
Highly Efficient ◽  
Biphasic Ceramic

Yolk–shell biphasic granules characterized by tunable ion release and interconnected channel evolution mediate efficient alveolar bone repair.

scholarly journals Rational design of nonstoichiometric bioceramic scaffolds via digital light processing: tuning chemical composition and pore geometry evaluation

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yifan Li ◽  
Ronghuan Wu ◽  
Li Yu ◽  
Miaoda Shen ◽  
Xiaoquan Ding ◽  
...  
Keyword(s):  
Rational Design ◽  
Bone Repair ◽  
Pore Geometry ◽  
Porous Structures ◽  
Ion Release ◽  
Digital Light Processing ◽  
Cylindrical Pore ◽  
Mechanical Strengths ◽  
Ceramic Stereolithography ◽  
Mg Doped

AbstractBioactive ceramics are promising candidates as 3D porous substrates for bone repair in bone regenerative medicine. However, they are often inefficient in clinical applications due to mismatching mechanical properties and compromised biological performances. Herein, the additional Sr dopant is hypothesized to readily adjust the mechanical and biodegradable properties of the dilute Mg-doped wollastonite bioceramic scaffolds with different pore geometries (cylindrical-, cubic-, gyroid-) by ceramic stereolithography. The results indicate that the compressive strength of Mg/Sr co-doped bioceramic scaffolds could be tuned simultaneously by the Sr dopant and pore geometry. The cylindrical-pore scaffolds exhibit strength decay with increasing Sr content, whereas the gyroid-pore scaffolds show increasing strength and Young’s modulus as the Sr concentration is increased from 0 to 5%. The ion release could also be adjusted by pore geometry in Tris buffer, and the high Sr content may trigger a faster scaffold bio-dissolution. These results demonstrate that the mechanical strengths of the bioceramic scaffolds can be controlled from the point at which their porous structures are designed. Moreover, scaffold bio-dissolution can be tuned by pore geometry and doping foreign ions. It is reasonable to consider the nonstoichiometric bioceramic scaffolds are promising for bone regeneration, especially when dealing with pathological bone defects.

Evaluation of the effects of the use of platelet-rich plasma (PRP) on alveolar bone repair following extraction of impacted third molars: Prospective study

2013 ◽  
Vol 41 (4) ◽  
pp. e70-e75 ◽  
Author(s):  
Guilherme de Marco Antonello ◽  
Ricardo Torres do Couto ◽  
Caroline Comis Giongo ◽  
Marcos Britto Corrêa ◽  
Otacílio Luiz Chagas Júnior ◽  
...  
Keyword(s):  
Prospective Study ◽  
Bone Repair ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Third Molars

scholarly journals Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

2018 ◽  
Vol 26 (0) ◽  
Author(s):  
André Boziki Xavier do Carmo ◽  
Suelen Cristina Sartoretto ◽  
Adriana Terezinha Neves Novellino Alves ◽  
José Mauro Granjeiro ◽  
Fúlvio Borges Miguel ◽  
...  
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Carbonated Hydroxyapatite

Alveolar bone repair following extraction of impacted mandibular third molars

1986 ◽  
Vol 61 (4) ◽  
pp. 324-326 ◽  
Author(s):  
Yitzhak Marmary ◽  
Laurence Brayer ◽  
Aaron Tzukert ◽  
Liviu Feller
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Third Molars ◽  
Impacted Mandibular Third Molars ◽  
Mandibular Third Molars

A New Method for Alveolar Bone Repair Using Extracted Teeth for the Graft Material

2010 ◽  
Vol 81 (9) ◽  
pp. 1264-1272 ◽  
Author(s):  
Tomoki Nampo ◽  
Junichi Watahiki ◽  
Akiko Enomoto ◽  
Tomohiro Taguchi ◽  
Miki Ono ◽  
...  
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
New Method ◽  
Graft Material

scholarly journals WNT3A accelerates delayed alveolar bone repair in ovariectomized mice

2019 ◽  
Vol 30 (9) ◽  
pp. 1873-1885 ◽  
Author(s):  
Y. Liu ◽  
Z. Li ◽  
M. Arioka ◽  
L. Wang ◽  
C. Bao ◽  
...  
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Ovariectomized Mice

scholarly journals Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

Materials ◽  
2019 ◽  
Vol 12 (22) ◽  
pp. 3645 ◽  
Author(s):  
Rodrigo F. B. Resende ◽  
Suelen C. Sartoretto ◽  
Marcelo J. Uzeda ◽  
Adriana T. N. N. Alves ◽  
José A. Calasans-Maia ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Repair ◽  
Alveolar Bone ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Double Blind ◽  
Socket Preservation ◽  
Carbonated Hydroxyapatite ◽  
Randomized Controlled

The properties of the biodegradation of bone substitutes in the dental socket after extraction is one of the goals of regenerative medicine. This double-blind, randomized, controlled clinical trial aimed to compare the effects of a new bioabsorbable nanostructured carbonated hydroxyapatite (CHA) with a commercially available bovine xenograft (Bio-Oss®) and clot (control group) in alveolar preservation. Thirty participants who required tooth extraction and implant placement were enrolled in this study. After 90 days, a sample of the grafted area was obtained for histological and histomorphometric evaluation and an implant was installed at the site. All surgical procedures were successfully carried out without complications and none of the patients were excluded. The samples revealed a statistically significant increase of new bone formation (NFB) in the CHA group compared with Bio-Oss® after 90 days from surgery (p < 0.05). However, the clot group presented no differences of NFB compared to CHA and Bio-Oss®. The CHA group presented less amount of reminiscent biomaterial compared to Bio-Oss®. Both biomaterials were considered osteoconductors, easy to handle, biocompatible, and suitable for alveolar filling. Nanostructured carbonated hydroxyapatite spheres promoted a higher biodegradation rate and is a promising biomaterial for alveolar socket preservation before implant treatment.

scholarly journals Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria

2019 ◽  
Vol 48 ◽  
Author(s):  
Mauricio Andrés Tinajero ARONI ◽  
Paulo Firmino da COSTA NETO ◽  
Guilherme José Pimentel Lopes de OLIVEIRA ◽  
Rosemary Adriana Chiérici MARCANTONIO ◽  
Elcio MARCANTONIO JUNIOR
Keyword(s):  
Bone Graft ◽  
Bone Substitute ◽  
Bone Repair ◽  
Bone Substitutes ◽  
Autogenous Bone ◽  
Bovine Bone ◽  
Rat Calvaria ◽  
Mineralized Tissues ◽  
Bone Graft Substitutes ◽  
Biphasic Ceramic

Abstract Introduction The use of bone substitutes in grafting procedures as an alternative of the use of autogenous bone graft has been indicated, however, the direct comparison between these biomaterials has been little explored. Objective To evaluate the effect of different osteoconductive bone substitutes on the bone repair in critical-sized defects (CSDs) in rat calvaria. Material and method One CSD with an 8 mm diameter was made in each of the 40 rats used in this study. The animals were randomly allocated into 5 groups (n=8), according to the type of bone substitute used to fill the CSD: COA (Coagulum); AUT (autogenous bone); DBB (deproteinized bovine bone graft); HA/TCP (biphasic ceramic composed of hydroxyapatite and β-phosphate tricalcium); and TCP (β-phosphate tricalcium). A microtomographic analysis was performed to evaluate the remaining defect linear length (DLL) of the CSD and the volume of the mineralized tissues (MT) within the CSD at 3, 7, 15 and 30 days after the surgical procedure. In addition, a histometric analysis was performed to evaluate the composition of the repaired bone tissue (% Bone and % Biomaterial) at the 30-day period. Result It was shown that the COA had the lowest DLL and MT within the CSD. In addition, the COA presented the highest % of bone in CSD. The DBB had a higher MT and a higher % of bone substitute particles in the CSD than the AUT and TCP groups. The DBB and AUT groups presented higher % of bone in the CSD than the TCP group. Conclusion The use of the DBB promoted a better pattern of bone volume gain and formation compared to TCP and HA / TCP but was biologically inferior to the AUT.

Animal Experimental Study on Repair of Alveolar Bone Defect with Double-Pipe Biphase Bioceramic Polyetheretherketone Composite

2020 ◽  
Vol 10 (8) ◽  
pp. 1236-1241
Author(s):  
Wei Wang ◽  
Pengtao Zhang ◽  
Yuqi Zhou ◽  
Yuzhu Jia ◽  
Lei Zhang
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Bone Defects ◽  
Control Group ◽  
Alveolar Ridge ◽  
Mineral Density ◽  
Repair Rate ◽  
Bone Injury ◽  
Injury Model ◽  
Ridge Height

Polyetheretherketone (PEEK) has the advantages of good biocompatibility, thus become a widely used bone remodeling material. Bioceramics are also highly effective bone repair materials. However, the repairing effect of biphasic bioceramics combined with polyetheretherketone composites on alveolar bone defects has not been elucidated. SD rats were separated into control group that was established as alveolar bone injury model; PEEK group that the alveolar bone injury model was repaired with polyether ether ketone; and composite group that alveolar bone injury model was repaired with double-tube biphase bioceramic/polyetheretherketone. After 8 weeks of treatment, the bone mineral density (BMD) changes were assessed by X-ray absorptiometry. HE staining was used to analyze the changes of tooth defect. The change of alkaline phosphatase (ALP) content was analyzed. Real-time PCR was performed to measure osteogenic factors Opn and Runx2 expressions. Serum BMP-2 level was analyzed by ELISA. The alveolar ridge height was compared and the alveolar bone repair rate was calculated. In the PEEK group and the composite group, BMD was significantly increased, bone was repaired, Runx2 and Opn mRNA expression was upregulated and ALP activity was enhanced along with elevated BMP-2 secretion, alveolar ridge height and bone repair rate compared to control group (P < 0 05). The composite group exhibited more significant changes compared with PEEK group (P < 0 05). Double-tube biphasic bioceramic/polyetheretherketone composites can repair alveolar bone defects, promote osteogenic differentiation, induce BMP-2 secretion, enhance bone density, and accelerate alveolar bone repair.

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