Biocompatible polypeptide-based interpenetrating network (IPN) hydrogels with enhanced mechanical properties

2020 ◽  
Vol 8 (34) ◽  
pp. 7785-7791
Author(s):  
Shona O’Brien ◽  
Ruairí P. Brannigan ◽  
Rita Ibanez ◽  
Bing Wu ◽  
Joanne O’Dwyer ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Interpenetrating Network ◽  
Synthetic Polypeptide

Herein, we present the synthesis of novel synthetic polypeptide-based interpenetrating network (IPN) hydrogels with enhanced mechanical properties, and biocompatability.

Development of visible-light responsive and mechanically enhanced “smart” UCST interpenetrating network hydrogels

Soft Matter ◽  
2018 ◽  
Vol 14 (1) ◽  
pp. 151-160 ◽  
Author(s):  
Yifei Xu ◽  
Onkar Ghag ◽  
Morgan Reimann ◽  
Philip Sitterle ◽  
Prithwish Chatterjee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Visible Light ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Solution Temperature ◽  
Interpenetrating Network ◽  
Critical Solution Temperature ◽  
Smart Hydrogel ◽  
Upper Critical Solution Temperature

An interpenetrating polymer network, chlorophyllin-incorporated “smart” hydrogel was synthesized and exhibited enhanced mechanical properties, upper critical solution temperature swelling, and promising visible-light responsiveness.

scholarly journals Microstructure and Mechanical Properties of Heterogeneous Ceramic-Polymer Composite Using Interpenetrating Network

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Eun-Hee Kim ◽  
Yeon-Gil Jung ◽  
Chang-Yong Jo
Keyword(s):  
Mechanical Properties ◽  
Fracture Strength ◽  
Porous Alumina ◽  
Porous Ceramic ◽  
Crosslinking Density ◽  
Porous Matrix ◽  
Interpenetrating Network ◽  
Polyurethane Acrylate ◽  
The Matrix ◽  
Distribution Of Stress

Prepolymer, which can be polymerized by a photo, has been infiltrated into a porous ceramic to improve the addition effect of polymer into the ceramic, as a function of the functionality of prepolymer. It induces the increase in the mechanical properties of the ceramic. The porous alumina (Al2O3) and the polyurethane acrylate (PUA) with a network structure by photo-polymerization were used as the matrix and infiltration materials, respectively. The porous Al2O3matrix without the polymer shows lower values in fracture strength than the composites, since the stress is transmitted more quickly via propagation of cracks from intrinsic defects in the porous matrix. However, in the case of composites, the distribution of stress between heterophases results in the improved mechanical properties. In addition, the mechanical properties of composites, such as elastic modulus and fracture strength, are enhanced with increasing the functionality of prepolymer attributed to the crosslinking density of polymer.

scholarly journals Tunable Fibrin-Alginate Interpenetrating Network Hydrogels to Guide Cell Behavior

2019 ◽  
Author(s):  
Charlotte E. Vorwald ◽  
Tomas Gonzalez-Fernandez ◽  
Shreeya Joshee ◽  
Pawel Sikorski ◽  
J. Kent Leach
Keyword(s):  
Mechanical Properties ◽  
Network Formation ◽  
Mesh Size ◽  
Crosslinking Density ◽  
Biomechanical Properties ◽  
Capillary Network ◽  
Natural Polymers ◽  
Interpenetrating Network ◽  
Tunable Mechanical Properties ◽  
Fibrinogen Content

ABSTRACTHydrogels are effective platforms for use as artificial extracellular matrices, cell carriers, and to present bioactive cues. Two common natural polymers, fibrin and alginate, are broadly used to form hydrogels and have numerous advantages over synthetic materials. Fibrin is a provisional matrix containing native adhesion motifs for cell engagement, yet the interplay between mechanical properties, degradation, and gelation rate is difficult to decouple. Conversely, alginate is highly tunable yet bioinert and requires modification to present necessary adhesion ligands. To address these challenges, we developed a fibrin-alginate interpenetrating network (IPN) hydrogel to combine the desirable adhesion and stimulatory characteristics of fibrin with the tunable mechanical properties of alginate. We tested its efficacy by examining capillary network formation with entrapped co-cultures of mesenchymal stromal cells (MSCs) and endothelial cells (ECs). We manipulated thrombin concentration and alginate crosslinking density independently to modulate the fibrin structure, mesh size, degradation, and biomechanical properties of these constructs. In IPNs of lower stiffness, we observed a significant increase in total cell area (1.72×105 ± 7.9×104 μm2) and circularity (0.56 ± 0.03) compared to cells encapsulated in stiffer IPNs (3.98×104 ± 1.49×104 μm2 and 0.77 ± 0.09, respectively). Fibrinogen content did not influence capillary network formation. However, higher fibrinogen content led to greater retention of these networks confirmed via increased spreading and presence of F-actin at 7 days. This is an elegant platform to decouple cell adhesion and hydrogel bulk stiffness that will be broadly useful for cell instruction and delivery.

Incorporation of Fmoc-Y nanofibers into Ca-alginate hydrogels for improving their mechanical properties and the controlled release of small molecules

2018 ◽  
Vol 42 (12) ◽  
pp. 9651-9657 ◽  
Author(s):  
Jiahui Chen ◽  
Na Tao ◽  
Shiqi Fang ◽  
Zewen Chen ◽  
Li Liang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Controlled Release ◽  
Small Molecules ◽  
Calcium Alginate ◽  
Interpenetrating Network ◽  
Alginate Hydrogels ◽  
Ca Alginate

A robust interpenetrating network (IPN) hydrogel was assembled from calcium alginate and Fmoc-tyrosine for the controlled release of small molecules.

Hyperbranched Polyether and Polyether-Urethane Composites with Interpenetrating Networks

2012 ◽  
Vol 529 ◽  
pp. 550-554 ◽  
Author(s):  
Xue Jing Song ◽  
Yun Jun Luo
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Hydrogen Bonding ◽  
Synergetic Effect ◽  
Control Sample ◽  
Dual Phase ◽  
Isophorone Diisocyanate ◽  
Interpenetrating Network ◽  
Interpenetrating Networks ◽  
Hyperbranched Polyether

In order to improve mechanical properties of polyurethane, hyperbranched interpenetrating network(H-IPN) was achieved by incorporating hyperbranched polyethrs into polyether-Urethane that derived from hydroxyl terminated ethylene oxide tetrahydrofuran copolyether (PET) and isophorone diisocyanate (IPDI). It was found that H-IPN exhibited dual-phase morphology, and hydrogen bonding was formed between hyperbranch polyether and polyether-Urethane. H-IPN shows synergetic effect, the tensile strength of H-IPN increased from 1.39MPa of neat polyether-Urethane to 2.67 MPa; Meanwhile, the elongation increased from 605% of control sample to 2304%.

scholarly journals Designing polymer nanocomposites with a semi-interpenetrating or interpenetrating network structure: toward enhanced mechanical properties

2017 ◽  
Vol 19 (24) ◽  
pp. 15808-15820 ◽  
Author(s):  
Wenhui Wang ◽  
Guanyi Hou ◽  
Zijian Zheng ◽  
Lu Wang ◽  
Jun Liu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Polymer Nanocomposites ◽  
Network Structure ◽  
Network Structures ◽  
Interpenetrating Network ◽  
Uniform Dispersion

Semi-interpenetrating and interpenetrating network structures for the uniform dispersion of NPs and the reinforced mechanical properties of polymer nanocomposites.

scholarly journals Preparation and Properties of Toluene-Diisocyanate-Trimer-Modified Epoxy Resin

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 416 ◽  
Author(s):  
Xiongfei Zhang ◽  
Lu Qiao ◽  
Xiaolian Lu ◽  
Linqi Jiang ◽  
Ting Cao
Keyword(s):  
Mechanical Properties ◽  
Corrosion Resistance ◽  
Epoxy Resin ◽  
Network Structure ◽  
High Performance ◽  
Toluene Diisocyanate ◽  
Interpenetrating Network ◽  
Resin Curing ◽  
Modified Epoxy ◽  
Polyurethane Prepolymer

In this paper, a novel modified epoxy resin with an interpenetrating network structure for use as a grouting material with high toughness was prepared by a method of graft copolymerization between polyurethane prepolymer (PUP) trimer and epoxy resin (E-44). Polyurethane prepolymer was synthesized using poly(propylene glycol) (PPG) and 2,4-toluene diisocyanate trimer (TDIT) at 70 °C for 3 h. The graft copolymer was prepared by grafting polyurethane prepolymer onto the side chain of epoxy resin at 110 °C. The mechanical properties, fracture surface morphology, chemical structure, thermal properties, and corrosion resistance of the modified epoxy resin curing products were studied. Due to the beneficial flexible segments and the interpenetrating network structure, the results show that when the ratio of epoxy resin to polyurethane prepolymer is 10:2, the optimum mechanical properties are obtained; these include a compressive resistance of 184.8 MPa, impact property of 76.6 kJ/m2, and elongation at break of 31.5%. At the same time, the modified epoxy resin curing product also has excellent heat and corrosion resistance. This work provides a new method for the study of epoxy resins with high performance.

Effect of porous Si3N4 preform on the mechanical properties of Si3N4/Al composites with interpenetrating network structure

2014 ◽  
Vol 607 ◽  
pp. 307-312 ◽  
Author(s):  
Bo Wang ◽  
Zhao-Yun Xu ◽  
Wei-Zhong Lu ◽  
Feng Jin ◽  
Jian-Feng Yang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Network Structure ◽  
Interpenetrating Network ◽  
Porous Si3n4
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